公开(公告)号：US20130035290A1

公开(公告)日：2013-02-07

申请号：US13474011

申请日：2012-05-17

申请人： Jack A. Elias ,  Chirag R. Parikh ,  Lloyd G. Cantley

发明人： Jack A. Elias ,  Chirag R. Parikh ,  Lloyd G. Cantley

IPC分类号： G01N33/566 ,  A61P13/12 ,  A61K38/17 ,  C12Q1/68 ,  C40B30/04

CPC分类号： A61K38/47 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/6887 ,  G01N33/6893 ,  G01N2333/924 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/54 ,  G01N2800/56

摘要： The present invention provides compositions and methods for the detection, treatment, and prevention of a kidney injury. The invention relates to the discovery that chitinase 3-like 1/Brp-39/YKL-40 serves as both a biomarker for the degree of kidney injury and a critical mediator of a reparative response in the kidney.

摘要翻译： 本发明提供了用于检测，治疗和预防肾损伤的组合物和方法。 本发明涉及几丁质酶3样1 / Brp-39 / YKL-40用作肾损伤程度的生物标志物和肾脏修复反应的关键介质的发现。

公开(公告)号：US07141382B1

公开(公告)日：2006-11-28

申请号：US10964201

申请日：2004-10-12

申请人： Chirag R. Parikh ,  Charles L. Edelstein

发明人： Chirag R. Parikh ,  Charles L. Edelstein

IPC分类号： G01N33/53

CPC分类号： G01N33/6869 ,  G01N2800/125 ,  G01N2800/347

摘要： The present disclosure concerns methods of detecting a molecule, interleukin 18, in a sample, and using the detection of IL-18 to predict a condition. In a particular embodiment, the present invention concerns methods of detecting interleukin 18, in a sample, preferably prior to the increase in serum creatinine in a subject predisposed to a condition. In certain embodiments, the methods may comprise obtaining a sample from a subject such as a urine or blood sample and analyzing the sample for the presence or absence of IL-18 to predict a condition for example acute renal failure or organ transplant failure. In another embodiment, the methods may comprise analyzing a sample from a subject for the presence of IL-18 and applying information obtained from analyzing the presence of IL-18 to determine a treatment for a medical condition of the subject.

摘要翻译： 本公开涉及检测样品中的分子，白介素18，以及使用IL-18的检测来预测病症的方法。 在一个具体实施方案中，本发明涉及在样品中检测白细胞介素18的方法，优选在倾向于病症的受试者中血清肌酐升高之前。 在某些实施方案中，所述方法可以包括从受试者例如尿液或血液样品获得样品，并分析样品中IL-18的存在或不存在以预测例如急性肾衰竭或器官移植失败的病症。 在另一个实施方案中，所述方法可以包括分析来自受试者的样品中IL-18的存在并应用从分析IL-18的存在获得的信息，以确定对受试者的医学状况的治疗。

公开(公告)号：US20180268503A1

公开(公告)日：2018-09-20

申请号：US15922812

申请日：2018-03-15

申请人： Manav C. PARIKH ,  Chirag R. PARIKH ,  Ronak R. PARIKH

发明人： Manav C. PARIKH ,  Chirag R. PARIKH ,  Ronak R. PARIKH

IPC分类号： G06Q50/12 ,  G06K19/06 ,  G06Q30/06 ,  G06K7/14

CPC分类号： G06Q50/12 ,  G06K7/1417 ,  G06K19/06037 ,  G06Q30/0627

摘要： A personalized QR or other machine-readable code is presented by a user at an establishment where a selection of items is presented to users. In a preferred embodiment the machine-readable code is printed on or attached to a wearable accessory such as a bracelet or necklace, but could also be carried on a card, for example. The personalized QR code is created based on a person's individual preferences or restrictions. In the food/restaurant example, it is personalized based on the person's allergens. The establishment is provided with a device configured to read the QR code presented by the user and process the individual preferences so as to only present to the user a list of a subset of the available items, all of which meet the user's preferences and/or restriction requirements.