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公开(公告)号：US20140248633A1
公开(公告)日：2014-09-04
申请号：US14130909
申请日：2012-07-09
申请人： Chong-xian Pan , Hongyong Zhang
发明人： Chong-xian Pan , Hongyong Zhang
IPC分类号： C07K7/06 , G01N33/574
CPC分类号： C07K7/06 , A61K47/62 , A61K47/6907 , A61K51/08 , C07K2319/30 , G01N33/57426 , G01N2333/7056
摘要： The present invention is directed to C-type lectin-like molecule-1 (CLL1) specific ligand peptides, comprising the amino acid motif LR(S/T), and methods of their use, e.g., for imaging detection for diagnosis of leukemia and the presence of leukemic stem cells (LSCs) and targeted therapy against leukemia mediated at least in part by CLL1-expressing LSCs.
摘要翻译： 本发明涉及包含氨基酸基序LR（S / T）的C型凝集素样分子-1（CLL1）特异性配体肽及其使用方法，例如用于诊断白血病的成像检测和 白细胞干细胞（LSCs）的存在和至少部分由CLL1表达的LSCs介导的针对白血病的靶向治疗。
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公开(公告)号：US20120230994A1
公开(公告)日：2012-09-13
申请号：US13497041
申请日：2010-09-23
申请人： Chong-xian Pan , Hongyong Zhang , Kit S. Lam , Olulanu H. Aina
发明人： Chong-xian Pan , Hongyong Zhang , Kit S. Lam , Olulanu H. Aina
IPC分类号： A61K39/395 , C07K7/06 , C07K19/00 , A61P35/00 , G01N21/64 , G01N21/76 , G01N27/72 , A61K38/03 , C07K4/00 , G01N33/53
CPC分类号： A61K47/48246 , A61K9/0019 , A61K9/51 , A61K38/00 , A61K47/51 , A61K47/64 , A61K47/66 , A61K49/0002 , A61K49/0032 , A61K49/0056 , A61K51/088 , B82Y5/00 , C07K7/06 , G01N33/57407
摘要： The present invention is directed to bladder cancer specific ligand peptides, comprising the amino acid sequence X1DGRX5GF (SEQ ID NO:1), and methods of their use, e.g., for imaging detection for diagnosis of bladder, tumor localization to guide transurethral resection of bladder cancer, imaging detection of bladder cancer for follow-up after the initial treatment that can replace or complement costly cystoscopy, imaging detection of metastatic bladder cancer, and targeted therapy for superficial and metastatic bladder cancer.
摘要翻译： 本发明涉及包含氨基酸序列X1DGRX5GF（SEQ ID NO：1）的膀胱癌特异性配体肽及其使用方法，例如用于膀胱诊断的成像检测，用于引导膀胱经尿道切除的肿瘤定位 癌症，成像检测膀胱癌的初步治疗后的后续可以替代或补充昂贵的膀胱镜检查，成像检测转移性膀胱癌和靶向治疗浅表和转移性膀胱癌。
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公开(公告)号：US08946379B2
公开(公告)日：2015-02-03
申请号：US13497041
申请日：2010-09-23
申请人： Chong-xian Pan , Hongyong Zhang , Kit S. Lam , Olulanu H. Aina
发明人： Chong-xian Pan , Hongyong Zhang , Kit S. Lam , Olulanu H. Aina
CPC分类号： A61K47/48246 , A61K9/0019 , A61K9/51 , A61K38/00 , A61K47/51 , A61K47/64 , A61K47/66 , A61K49/0002 , A61K49/0032 , A61K49/0056 , A61K51/088 , B82Y5/00 , C07K7/06 , G01N33/57407
摘要： The present invention is directed to bladder cancer specific ligand peptides, comprising the amino acid sequence X1DGRX5GF (SEQ ID NO:1), and methods of their use, e.g., for imaging detection for diagnosis of bladder, tumor localization to guide transurethral resection of bladder cancer, imaging detection of bladder cancer for follow-up after the initial treatment that can replace or complement costly cystoscopy, imaging detection of metastatic bladder cancer, and targeted therapy for superficial and metastatic bladder cancer.
摘要翻译： 本发明涉及包含氨基酸序列X1DGRX5GF（SEQ ID NO：1）的膀胱癌特异性配体肽及其使用方法，例如用于膀胱诊断的成像检测，用于引导膀胱经尿道切除的肿瘤定位 癌症，成像检测膀胱癌的初步治疗后的后续可以替代或补充昂贵的膀胱镜检查，成像检测转移性膀胱癌和靶向治疗浅表和转移性膀胱癌。
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公开(公告)号：US09334306B2
公开(公告)日：2016-05-10
申请号：US14130909
申请日：2012-07-09
申请人： Chong-xian Pan , Hongyong Zhang
发明人： Chong-xian Pan , Hongyong Zhang
IPC分类号： C07K7/06 , G01N33/574 , A61K47/48
CPC分类号： C07K7/06 , A61K47/62 , A61K47/6907 , A61K51/08 , C07K2319/30 , G01N33/57426 , G01N2333/7056
摘要： The present invention is directed to C-type lectin-like molecule-1 (CLL1) specific ligand peptides, comprising the amino acid motif LR(S/T), and methods of their use, e.g., for imaging detection for diagnosis of leukemia and the presence of leukemic stem cells (LSCs) and targeted therapy against leukemia mediated at least in part by CLL1-expressing LSCs.
摘要翻译： 本发明涉及包含氨基酸基序LR（S / T）的C型凝集素样分子-1（CLL1）特异性配体肽及其使用方法，例如用于诊断白血病的成像检测和 白细胞干细胞（LSCs）的存在和至少部分由CLL1表达的LSCs介导的针对白血病的靶向治疗。
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