公开(公告)号：US11071951B2

公开(公告)日：2021-07-27

申请号：US16587012

申请日：2019-09-29

Applicant: Choon Kee Lee

Inventor： Choon Kee Lee

IPC: B01D63/16 ,  B01D63/02 ,  A61M1/34 ,  A61M1/36 ,  A61M1/16 ,  B01D61/28

Abstract: The present invention provides a hemodiafiltrator comprising two compartmentalized dialysate chambers coaxially arranged in tandem. A single packed bundle of hollow fibers for blood flow is enclosed coaxially along a longitudinal axis inside the dual dialysate chambers. A configuration of a tandem arrangement of the dual dialysate chambers at least comprises a first dialysate chamber for an acidic dialysate with a varying level of urea and a second compartmentalized dialysate chamber for a basic dialysate with no urea but with a level of ammonia up to a level detected in normal human blood.

公开(公告)号：US10736371B2

公开(公告)日：2020-08-11

申请号：US15283375

申请日：2016-10-01

Applicant: Choon Kee Lee

Inventor： Choon Kee Lee

IPC: A42B3/06 ,  A42B3/12 ,  A42B3/28

Abstract: The present invention provides a protective headgear having a multi-layered shell to attenuate amplitude of mechanical waves of a blunt trauma to a human head by phase reversal of the mechanical waves at a boundary established between two adjacent layers of the multi-layered shell.

公开(公告)号：US20180047305A1

公开(公告)日：2018-02-15

申请号：US15232799

申请日：2016-08-09

Applicant: Choon Kee Lee

Inventor： Choon Kee Lee

IPC: G09B23/32

CPC classification number: G09B23/32 ,  G01L5/0052 ,  G01M7/08

Abstract: The present invention provides an apparatus and methods to quantitatively measure a physical perturbation to a human head model by a mechanical impact of a blunt trauma. The apparatus is configured to obtain a set of non-contact measurement data from the human head model upon the mechanical impact. A source of the mechanical impact is configured to vary in kinetic energy by varying weight of the source and speed of the mechanical impact.

公开(公告)号：US09649161B2

公开(公告)日：2017-05-16

申请号：US14160492

申请日：2014-01-21

Applicant: Choon Kee Lee

Inventor： Choon Kee Lee

IPC: A61B19/00 ,  A61B8/08 ,  A61B10/02 ,  A61B8/00 ,  A61B90/11 ,  A61B17/34

CPC classification number: A61B90/11 ,  A61B8/0841 ,  A61B8/4272 ,  A61B10/0266 ,  A61B2017/3409 ,  A61B2017/3413

Abstract: The present invention presents an apparatus and methods to stereotactically guide insertion of invasive tubular devices to a tissue object of a living body. The apparatus comprises a positioning guide control assembly and a positioning guide assembly that is operably detachable from the positioning guide control assembly, and rotationally adjustable and lockable. The positioning guide control assembly releasably houses a ultrasound transducer head to visualize and target the tissue object and adjusts an insertion angle of an invasive tubular device placed in the positioning guide assembly.

公开(公告)号：US20160120572A1

公开(公告)日：2016-05-05

申请号：US14527736

申请日：2014-10-29

Applicant: Choon Kee Lee

Inventor： Choon Kee Lee

IPC: A61B17/34 ,  A61B8/00 ,  A61B8/08

CPC classification number: A61B17/3403 ,  A61B8/0841 ,  A61B8/4281 ,  A61B8/4444 ,  A61B2017/00924 ,  A61B2017/3413

Abstract: The present invention presents a static pointing device and methods to guide insertion of an invasive tubular device to a tissue object of a living body. The static pointing device is coupled with an ultrasound positioning apparatus, located in front of an ultrasound transducer and produces a linear shadow line in a visualized ultrasonographic field. An ultrasonographic view of a tissue object can be marked by the linear shadow line crossing said tissue object. An invasive tubular device held by the ultrasound positioning apparatus can be directed to the tissue object by calculated angulation of said invasive tubular device to have a longitudinal axis of said invasive tubular device cross the linear shadow line in the tissue object.

Abstract translation: 本发明提供一种静态指示装置和引导将侵入性管状装置插入生物体的组织物体的方法。 静态指示装置与位于超声换能器前方的超声定位装置相连，并在可视化超声波场中产生线性阴影线。 可以通过与所述组织物体交叉的线性阴影线来标记组织物体的超声波视图。 由超声定位装置保持的侵入性管状装置可以通过所述侵入性管状装置的计算角度被引导到组织物体，以使所述侵入性管状装置的纵向轴线与组织物体中的线性阴影线交叉。

公开(公告)号：US20160045222A1

公开(公告)日：2016-02-18

申请号：US14462320

申请日：2014-08-18

Applicant: Choon Kee Lee

Inventor： Choon Kee Lee

IPC: A61B17/34

CPC classification number: A61B90/11 ,  A61B2017/3409 ,  A61B2017/3413

Abstract: The present invention presents an apparatus and methods to stereotactically guide and automatically insert an invasive tubular device to a tissue object of a living body. The apparatus comprises a stereotactic positioning assembly and a powered propulsion assembly that controllably drives an invasive tubular device in and out of a tissue object. The stereotactic positioning assembly encloses an ultrasound transducer to visualize and aim at the tissue object, and adjusts an insertion angle of the invasive tubular device coupled with the powered propulsion assembly.

Abstract translation: 本发明提供了一种用于立体地引导和自动将侵入性管状装置插入生物体的组织物体的装置和方法。 该装置包括立体定位定位组件和动力推进组件，其可控制地将侵入性管状装置驱入和移出组织物体。 立体定位定位组件包围超声换能器以使组织物体可视化和瞄准，并且调节与动力推进组件联合的侵入式管状装置的插入角度。

公开(公告)号：US20150238265A1

公开(公告)日：2015-08-27

申请号：US14187285

申请日：2014-02-23

Applicant: Choon Kee Lee

Inventor： Choon Kee Lee

IPC: A61B19/00

CPC classification number: A61B34/20 ,  A61B8/0841 ,  A61B8/463 ,  A61B10/0233 ,  A61B90/11 ,  A61B2017/3409 ,  A61B2017/3413 ,  A61B2034/2063

Abstract: The present invention presents an apparatus and methods to stereotactically guide insertion of invasive tubular devices to a tissue object of a living body. The apparatus comprises a powered positioning guide control assembly and a positioning guide assembly that is operably detachable from the powered positioning guide control assembly, and rotationally adjustable and lockable. The powered positioning guide control assembly encloses an ultrasound transducer to visualize and target the tissue object, and adjusts an insertion angle of an invasive tubular device placed in the positioning guide assembly.

Abstract translation: 本发明提出了一种立体地引导将侵入性管状装置插入生物体的组织物体的装置和方法。 该设备包括动力定位引导控制组件和定位引导组件，该定位引导组件可操作地与动力定位引导控制组件分离，并且可旋转地调节和锁定。 动力定位导向器控制组件包围超声换能器以使组织物体可视化和目标，并且调节放置在定位导向器组件中的侵入式管状装置的插入角度。

公开(公告)号：US20150011971A1

公开(公告)日：2015-01-08

申请号：US13936182

申请日：2013-07-06

Applicant: Choon Kee Lee

Inventor： Choon Kee Lee

IPC: A61M5/42

CPC classification number: A61M5/422

Abstract: The present invention presents an apparatus and methods to generate and deliver resonant vibrations to a hypodermic needle penetration site of a human body to reduce pain of needle prick by activating inhibitory neuronal mechanisms for pain perception. The apparatus comprises a longitudinal syringe carriage assembly which releasably holds and slidably moves a proximal portion of a syringe and a vibration assembly which generates and delivers vibrations to a vibration resonance enclosure located at a proximal end of the apparatus. The vibration assembly adjoins in parallel the syringe carriage assembly. A syringe with a needle moves forward in the syringe carriage assembly along a longitudinal axis and the needle penetrates a recipient's tissue which is in direct contact with and is vibrated by the proximal end of the apparatus.

Abstract translation: 本发明提供了一种用于通过激活用于疼痛感知的抑制性神经元机制来产生和递送共振振动到人体的皮下注射针穿刺部位以减少针刺疼痛的装置和方法。 该装置包括纵向注射器支架组件，其可释放地保持并可滑动地移动注射器的近端部分和振动组件，该振动组件产生并将振动传递到位于装置的近端处的振动共振外壳。 振动组件与注射器支架组件平行地邻接。 具有针的注射器在注射器支架组件中沿着纵向轴线向前移动，并且针穿透接收者的组织，该接收者的组织与设备的近端直接接触并被振动。

公开(公告)号：US20140213931A1

公开(公告)日：2014-07-31

申请号：US13749679

申请日：2013-01-25

Applicant: Choon Kee Lee

Inventor： Choon Kee Lee

IPC: A61B10/02

CPC classification number: A61B10/0233 ,  A61B10/025 ,  A61B2010/0258 ,  A61M1/008

Abstract: The current invention presents a tissue sampling apparatus and methods to reliably obtain solid and liquid bone marrow samples in sequence in a single insertion of the apparatus to a target area. The apparatus comprises a proximal handle assembly, a distal cutting assembly and a shaft assembly connecting both assemblies. The handle assembly comprises an upper handle connected to an inner cutting tube and a lower handle connected to an outer cannula. The lower handle transmits axial rotation of the upper handle to longitudinal movement of the inner cutting tube. Axial rotation of an engaged upper handle longitudinally pulls out from the outer cannula the inner cutting tube that spirally holds fast a solid marrow sample inside a distal end of said inner cutting tube. Following acquisition of the solid marrow sample, a liquid marrow sample is aspirated through the outer cannula.

Abstract translation: 本发明提供一种组织取样装置和方法，以便在将装置单次插入目标区域中依次可靠地获得固体和液体骨髓样品。 该装置包括近端手柄组件，远端切割组件和连接两个组件的轴组件。 手柄组件包括连接到内切割管的上手柄和连接到外插管的下手柄。 下手柄将上手柄的轴向旋转传递到内切管的纵向运动。 接合的上把手的轴向旋转从外套管纵向拉出，内切割管螺旋地将固体骨髓样品快速保持在所述内切割管的远端内。 在获得固体骨髓样品后，通过外套管抽吸液体骨髓样品。

公开(公告)号：US20130190649A1

公开(公告)日：2013-07-25

申请号：US13355500

申请日：2012-01-21

Applicant: Choon Kee Lee

Inventor： Choon Kee Lee

IPC: A61B10/04

CPC classification number: A61B10/04 ,  A61B10/06

Abstract: Provided herein are a device and methods to obtain multiple serial samples from biologic tissues located in a tubular or cavitary space of a body. The device has a proximal and distal end, with a linear shaft connecting both ends. The distal end of the device comprises a tissue cutting assembly, a sample transport assembly and a sample storage assembly. The sample transport assembly comprises a slidable sample transport unit, a semi-cylindrical tubular sample chamber with a pair of axially linear rails located on both sides of said chamber and a system of differential pull wires. The sample transport unit slides on the rails of the sample chamber, providing longitudinally axial movement of the cup connected to said sample transport unit. The sample storage assembly comprises said sample chamber, a reversibly detachable sample catcher inserted in said sample chamber, a tubular sample housing and an expandable tubular sample housing.

Abstract translation: 本文提供了从身体的管状或空腔空间中的生物组织获得多个连续样品的装置和方法。 该装置具有近端和远端，连接两端的直线轴。 该装置的远端包括组织切割组件，样品输送组件和样品储存组件。 样品输送组件包括可滑动的样品输送单元，具有位于所述室的两侧的一对轴向线性轨道的半圆柱形管状样品室和差动拉线系统。 样品输送单元在样品室的轨道上滑动，提供连接到所述样品输送单元的杯的纵向轴向运动。 样品存储组件包括所述样品室，插入所述样品室中的可逆拆卸的样品捕集器，管状样品壳体和可扩张管状样品壳体。