公开(公告)号：US20180055888A1

公开(公告)日：2018-03-01

申请号：US15688148

申请日：2017-08-28

申请人： CHRISTIAN VAN DEN BOS ,  BARBARA REINISCH ,  JUDITH SCHENK ,  CLAUDIA ROSENBAUM

发明人： CHRISTIAN VAN DEN BOS ,  BARBARA REINISCH ,  JUDITH SCHENK ,  CLAUDIA ROSENBAUM

IPC分类号： A61K35/28 ,  C12N15/113 ,  C12N15/11 ,  A61K31/437 ,  A61K35/12

CPC分类号： A61K35/28 ,  A61K31/437 ,  A61K2035/124 ,  A61K2300/00 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2320/31

摘要： The invention encompasses compositions and method of treating a vascular disease such as peripheral artery disease, The methods involve—administering to a patient in need thereof, an effective amount of a composition comprising a population of cells such as mesenchymal stem cells (MSCs) and a non-muscle myosin 0 antagonist such as blebbistatin. Non-muscle myosin II antagonists are disclosed to surprisingly and dramatically accelerate MSC-triggered regeneration of damaged tissues arid unexpectedly and drastically reduce severe complications of stem cell treatment.

公开(公告)号：US20240316111A1

公开(公告)日：2024-09-26

申请号：US18734900

申请日：2024-06-05

申请人： Christian VAN DEN BOS

发明人： Christian VAN DEN BOS ,  Barbara REINISCH ,  Judith SCHENK ,  Claudia ROSENBAUM

IPC分类号： A61K35/28 ,  A61K31/437 ,  A61K35/12 ,  C12N15/11 ,  C12N15/113

CPC分类号： A61K35/28 ,  A61K31/437 ,  C12N15/111 ,  C12N15/113 ,  A61K2035/124 ,  A61K2300/00 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2320/31

摘要： The invention encompasses compositions and method of treating a vascular disease such as peripheral artery disease, The methods involve—administering to a patient in need thereof, an effective amount of a composition comprising a population of cells such as mesenchymal stem cells (MSCs) and a non-muscle myosin 0 antagonist such as blebbistatin. Non-muscle myosin II antagonists are disclosed to surprisingly and dramatically accelerate MSC-triggered regeneration of damaged tissues arid unexpectedly and drastically reduce severe complications of stem cell treatment.

公开(公告)号：US20200147142A1

公开(公告)日：2020-05-14

申请号：US16738495

申请日：2020-01-09

申请人： CHRISTIAN VAN DEN BOS

发明人： CHRISTIAN VAN DEN BOS ,  BARBARA REINISCH ,  JUDITH SCHENK ,  CLAUDIA ROSENBAUM

IPC分类号： A61K35/28 ,  C12N15/11 ,  C12N15/113 ,  A61K31/437

摘要： The invention encompasses compositions and method of treating a vascular disease such as peripheral artery disease, The methods involve—administering to a patient in need thereof, an effective amount of a composition comprising a population of cells such as mesenchymal stem cells (MSCs) and a non-muscle myosin 0 antagonist such as blebbistatin. Non-muscle myosin II antagonists are disclosed to surprisingly and dramatically accelerate MSC-triggered regeneration of damaged tissues arid unexpectedly and drastically reduce severe complications of stem cell treatment.

公开(公告)号：US20130295669A1

公开(公告)日：2013-11-07

申请号：US13884302

申请日：2011-11-09

申请人： Judith Schenk ,  Christian Van Den Bos ,  Claudia Rosenbaum ,  Ying Nie

发明人： Judith Schenk ,  Christian Van Den Bos ,  Claudia Rosenbaum ,  Ying Nie

IPC分类号： C12N5/0775

CPC分类号： C12N5/0606 ,  C12N5/0663 ,  C12N2501/727 ,  C12N2501/999 ,  C12N2531/00 ,  C12N2533/30 ,  C12N2533/90

摘要： The invention relates to a method for promoting the adhesion of cells to a substrate to which these cells usually have no or only low affinity, wherein the adhesion of the cells to the substrate is promoted by supplying the cells with the non-muscle myosin II inhibitor Blebbistatin so as to enable the cells to attach to surfaces to which they otherwise would not have sufficient affinity. Surprisingly, supplying the cells with the inhibitor enhances the capability of these cells to attach to surfaces to which they usually have no or only low affinity, for example, PTFE (Teflon®). The invention further concerns uses of the non-muscle myosin II inhibitor Blebbistatin and devices having at least one surface which is coated with cells that have no or only low affinity to said surface.

摘要翻译： 本发明涉及促进细胞对这些细胞通常不具有或仅具有低亲和力的底物的粘附的方法，其中通过向非细胞肌球蛋白II抑制剂供体细胞来促进细胞对底物的粘附 Blebbistatin，以便使细胞附着于否则不具有足够亲和力的表面。 令人惊奇的是，向细胞提供抑制剂增强了这些细胞附着到它们通常没有或仅具有低亲和力的表面（例如PTFE）的能力。 本发明还涉及非肌肉肌球蛋白II抑制剂Blebbistatin和具有至少一个表面的装置的使用，所述表面涂覆有对所述表面没有或仅具有低亲和力的细胞。