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公开(公告)号：US09889227B2
公开(公告)日：2018-02-13
申请号：US12299010
申请日：2008-07-08
CPC分类号： A61L27/306 , A61C8/0009 , A61F2/30767 , A61F2002/30677 , A61F2310/00598 , A61L27/06 , A61L27/50
摘要： A bone implant for implantation into bone tissue includes a metallic material having a surface that is covered by an oxide layer wherein the oxide layer has a thickness within the range of from 2 to 100 nm and includes strontium ions homogenously dispersed in the oxide layer. The oxide layer is a metal oxide layer formed from the metallic surface of the implant. The local administration of strontium ions in bone tissue has been found to improve the bone formation and bone mass upon implantation of a bone tissue implant in the bone tissue.
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公开(公告)号：US20120315310A1
公开(公告)日：2012-12-13
申请号：US13591151
申请日：2012-08-21
申请人： Stig HANSSON , Ingela Petersson
发明人： Stig HANSSON , Ingela Petersson
CPC分类号： A61F2/30767 , A61C8/0012 , A61F2/3094 , A61F2002/30929 , A61F2310/00023 , A61F2310/00598 , A61L27/306 , A61L2430/02
摘要： The present invention is based on that local administration of lithium ions in bone tissue has been found to improve the bone formation and bone mass upon implantation of a bone tissue implant in said bone tissue. In particular, the invention relates to a bone tissue implant having an implant surface covered by an oxide layer comprising lithium ions and a method for the manufacture thereof. A blasting powder comprising lithium ions, a method for locally increasing bone formation, and the use of lithium ions or a salt thereof for manufacturing a pharmaceutical composition for locally increasing bone formation are also provided by the present invention.
摘要翻译： 本发明基于在骨组织中的局部施用锂离子已经被发现在植入骨组织植入物在所述骨组织中时改善骨形成和骨量。 特别地，本发明涉及具有由包含锂离子的氧化物层覆盖的植入物表面的骨组织植入物及其制造方法。 本发明还提供了包含锂离子的爆炸粉末，局部增加骨形成的方法，以及使用锂离子或其盐来制造用于局部增加骨形成的药物组合物。
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公开(公告)号：US09744263B2
公开(公告)日：2017-08-29
申请号：US13591147
申请日：2012-08-21
CPC分类号： A61L27/306 , A61C8/0009 , A61F2/30767 , A61F2002/30677 , A61F2310/00598 , A61L27/06 , A61L27/50
摘要： The present invention is based on that local administration of strontium ions in bone tissue has been found to improve the bone formation and bone mass upon implantation of a bone tissue implant in said bone tissue. In particular, the invention relates to a bone tissue implant having an implant surface covered by an oxide layer comprising strontium ions and a method for the manufacture thereof. A blasting powder comprising strontium ions, a method for locally increasing bone formation, and the use of strontium ions or a salt thereof for manufacturing a pharmaceutical composition for locally increasing bone formation are also provided by the present invention.
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公开(公告)号：US08632836B2
公开(公告)日：2014-01-21
申请号：US12298884
申请日：2008-07-08
CPC分类号： A61F2/30767 , A61C8/0012 , A61C2008/0046 , A61F2/3094 , A61F2002/30719 , A61F2002/30906 , A61F2002/30925 , A61F2002/30929 , A61F2250/0092 , A61F2310/00023 , A61F2310/00598 , A61F2310/00616 , A61L27/306 , A61L2400/12 , B82Y5/00 , B82Y30/00 , C23C8/00 , C23C8/10 , C23C22/46 , C23C26/00 , C23G1/106
摘要： The invention relates to a method for modification of a biocompatible component comprising the steps of a) providing a biocompatible component at least partly covered by metallic oxide; and b) treating at least a part of said component, which part is covered by said metallic oxide, with an aqueous composition comprising oxalic acid; whereby a modified metallic oxide is obtained. The invention also relates to a biocompatible component comprising a substrate having a surface comprising a) a microstructure comprising pits separated by plateus and/or ridges; and b) a primary nanostructure being superimposed on said microstructure, said primary nanostructure comprising depressions arranged in a wave-like formation.
摘要翻译： 本发明涉及生物相容性成分的修饰方法，包括以下步骤：a）提供至少部分被金属氧化物覆盖的生物相容性成分; 和b）用包含草酸的含水组合物处理所述部分被所述金属氧化物覆盖的部分的至少一部分; 得到改性金属氧化物。 本发明还涉及一种生物相容性成分，其包含具有表面的基底，该基底包括a）微结构，其包括由平片和/或脊分离的凹坑; 和b）叠加在所述微结构上的初级纳米结构，所述初级纳米结构包括布置成波状结构的凹陷。
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公开(公告)号：US09642708B2
公开(公告)日：2017-05-09
申请号：US13620079
申请日：2012-09-14
IPC分类号： A61C8/00 , A61F2/30 , A61L27/30 , B82Y5/00 , B82Y30/00 , C23C8/00 , C23C8/10 , C23C22/46 , C23C26/00 , C23G1/10
CPC分类号： A61F2/30767 , A61C8/0012 , A61C2008/0046 , A61F2/3094 , A61F2002/30719 , A61F2002/30906 , A61F2002/30925 , A61F2002/30929 , A61F2250/0092 , A61F2310/00023 , A61F2310/00598 , A61F2310/00616 , A61L27/306 , A61L2400/12 , B82Y5/00 , B82Y30/00 , C23C8/00 , C23C8/10 , C23C22/46 , C23C26/00 , C23G1/106
摘要： The invention relates to a method for modification of a biocompatible component. The method of the invention includes the steps of a) providing a biocompatible component at least partly covered by metallic oxide; and b) treating at least a part of the component, which part is covered by the metallic oxide, with an aqueous composition that includes oxalic acid; whereby a modified metallic oxide, is obtained. The invention also relates to a biocompatible component-including a substrate having a surface with a) a microstructure including pits separated by plateus and/or ridges; and b) a primary nanostructure being superimposed on the microstructure, the primary nanostructure having depressions arranged in a wave-like formation.
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公开(公告)号：US20110151026A1
公开(公告)日：2011-06-23
申请号：US12298889
申请日：2008-07-08
申请人： Stig Hansson , Ingela Petersson
发明人： Stig Hansson , Ingela Petersson
CPC分类号： A61F2/30767 , A61C8/0012 , A61F2/3094 , A61F2002/30929 , A61F2310/00023 , A61F2310/00598 , A61L27/306 , A61L2430/02
摘要： The present invention is based on that local administration of lithium ions in bone tissue has been found to improve the bone formation and bone mass upon implantation of a bone tissue implant in said bone tissue.In particular, the invention relates to a bone tissue implant having an implant surface covered by an oxide layer comprising lithium ions and a method for the manufacture thereof.A blasting powder comprising lithium ions, a method for locally increasing bone formation, and the use of lithium ions or a salt thereof for manufacturing a pharmaceutical composition for locally increasing bone formation are also provided by the present invention.
摘要翻译： 本发明基于在骨组织中的局部施用锂离子已经被发现在植入骨组织植入物在所述骨组织中时改善骨形成和骨量。 特别地，本发明涉及具有由包含锂离子的氧化物层覆盖的植入物表面的骨组织植入物及其制造方法。 本发明还提供了包含锂离子的爆炸粉末，局部增加骨形成的方法，以及使用锂离子或其盐来制造用于局部增加骨形成的药物组合物。
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公开(公告)号：US08597676B2
公开(公告)日：2013-12-03
申请号：US13591151
申请日：2012-08-21
申请人： Stig Hansson , Ingela Petersson
发明人： Stig Hansson , Ingela Petersson
CPC分类号： A61F2/30767 , A61C8/0012 , A61F2/3094 , A61F2002/30929 , A61F2310/00023 , A61F2310/00598 , A61L27/306 , A61L2430/02
摘要： The present invention is based on that local administration of lithium ions in bone tissue has been found to improve the bone formation and bone mass upon implantation of a bone tissue implant in said bone tissue. In particular, the invention relates to a bone tissue implant having an implant surface covered by an oxide layer comprising lithium ions and a method for the manufacture thereof. A blasting powder comprising lithium ions, a method for locally increasing bone formation, and the use of lithium ions or a salt thereof for manufacturing a pharmaceutical composition for locally increasing bone formation are also provided by the present invention.
摘要翻译： 本发明基于在骨组织中的局部施用锂离子已经被发现在植入骨组织植入物在所述骨组织中时改善骨形成和骨量。 特别地，本发明涉及具有由包含锂离子的氧化物层覆盖的植入物表面的骨组织植入物及其制造方法。 本发明还提供了包含锂离子的爆炸粉末，局部增加骨形成的方法，以及使用锂离子或其盐来制造用于局部增加骨形成的药物组合物。
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公开(公告)号：US20100174382A1
公开(公告)日：2010-07-08
申请号：US12299010
申请日：2008-07-08
CPC分类号： A61L27/306 , A61C8/0009 , A61F2/30767 , A61F2002/30677 , A61F2310/00598 , A61L27/06 , A61L27/50
摘要： The present invention is based on that local administration of strontium ions in bone tissue has been found to improve the bone formation and bone mass upon implantation of a bone tissue implant in said bone tissue.In particular, the invention relates to a bone tissue implant having an implant surface covered by an oxide layer comprising strontium ions and a method for the manufacture thereof.A blasting powder comprising strontium ions, a method for locally increasing bone formation, and the use of strontium ions or a salt thereof for manufacturing a pharmaceutical composition for locally increasing bone formation are also provided by the present invention.
摘要翻译： 本发明基于在骨组织中的局部施用锶离子已经被发现在植入骨组织植入物在所述骨组织中时改善骨形成和骨量。 具体地说，本发明涉及具有由包含锶离子的氧化物层覆盖的植入物表面的骨组织植入物及其制造方法。 本发明还提供了包含锶离子的喷砂粉末，局部增加骨形成的方法，以及使用锶离子或其盐来制造用于局部增加骨形成的药物组合物。
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公开(公告)号：US20100173264A1
公开(公告)日：2010-07-08
申请号：US12298884
申请日：2008-07-08
CPC分类号： A61F2/30767 , A61C8/0012 , A61C2008/0046 , A61F2/3094 , A61F2002/30719 , A61F2002/30906 , A61F2002/30925 , A61F2002/30929 , A61F2250/0092 , A61F2310/00023 , A61F2310/00598 , A61F2310/00616 , A61L27/306 , A61L2400/12 , B82Y5/00 , B82Y30/00 , C23C8/00 , C23C8/10 , C23C22/46 , C23C26/00 , C23G1/106
摘要： The invention relates to a method for modification of a biocompatible component comprising the steps of a) providing a biocompatible component at least partly covered by metallic oxide; and b) treating at least a part of said component, which part is covered by said metallic oxide, with an aqueous composition comprising oxalic acid; whereby a modified metallic oxide is obtained. The invention also relates to a biocompatible component comprising a substrate having a surface comprising a) a microstructure comprising pits separated by plateus and/or ridges; and b) a primary nanostructure being superimposed on said microstructure, said primary nanostructure comprising depressions arranged in a wave-like formation.
摘要翻译： 本发明涉及生物相容性成分的修饰方法，包括以下步骤：a）提供至少部分被金属氧化物覆盖的生物相容性成分; 和b）用包含草酸的含水组合物处理所述部分被所述金属氧化物覆盖的部分的至少一部分; 得到改性金属氧化物。 本发明还涉及一种生物相容性成分，其包含具有表面的基底，该基底包括a）微结构，其包括由平片和/或脊分离的凹坑; 和b）叠加在所述微结构上的初级纳米结构，所述初级纳米结构包括布置成波状结构的凹陷。
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公开(公告)号：US20050234558A1
公开(公告)日：2005-10-20
申请号：US10519495
申请日：2003-05-06
申请人： Ingela Petersson , Kirstina June-Bostrom , Gunilla Johansson-Ruden , Fredrik Andersson , Stig Hansson
发明人： Ingela Petersson , Kirstina June-Bostrom , Gunilla Johansson-Ruden , Fredrik Andersson , Stig Hansson
CPC分类号： A61L27/56 , A61C2008/0046 , A61F2/30767 , A61F2002/30836 , A61F2002/30838 , A61F2002/30906 , A61F2002/30925 , A61F2002/3097 , A61F2310/00023 , A61F2310/00059 , A61F2310/00089 , A61F2310/00095 , A61F2310/00125 , A61F2310/00131 , A61L2400/18 , A61L2430/02
摘要： The invention relates to a method for treating an implant surface intended for implantation into bone tissue wherein a microroughness comprising pores and peaks having a pore diameter of ≦1 μm, a pore depth of ≦500 nm, and a peak width, at half the pore depth, of from 15 to 150% of the pore diameter is provided. The invention also relates to an implant comprising a surface having the above characteristics.
摘要翻译： 本发明涉及一种用于处理植入物表面以用于植入骨组织的方法，其中包括孔径为<=1μm，孔深度<= 500nm的孔隙和峰值的微粗糙度为一半 提供孔深的15至150％的孔深度。 本发明还涉及包括具有上述特征的表面的植入物。
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