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公开(公告)号:US07550487B2
公开(公告)日:2009-06-23
申请号:US11076162
申请日:2005-03-09
申请人: Lilli Anselm , Katrin Groebke Zbinden , Wolfgang Haap , Jacques Himber , Christoph Martin Stahl , Stefan Thomi
发明人: Lilli Anselm , Katrin Groebke Zbinden , Wolfgang Haap , Jacques Himber , Christoph Martin Stahl , Stefan Thomi
IPC分类号: A61K31/443 , A61K31/401 , C07D43/02
CPC分类号: C07D207/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12
摘要: The invention is concerned with novel pyrrolidine-3,4-dicarboxamide derivatives of formula (I) wherein R1 to R9 and X are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
摘要翻译: 本发明涉及式(I)的新型吡咯烷-3,4-二甲酰胺衍生物,其中R 1至R 9和X如说明书和权利要求书中所定义,以及其生理上可接受的盐。 这些化合物抑制凝血因子Xa,并且可以用作药物。
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公开(公告)号:US07501413B2
公开(公告)日:2009-03-10
申请号:US11263497
申请日:2005-10-31
申请人: Markus Boehringer , Katrin Groebke Zbinden , Wolfgang Haap , Hans Hilpert , Jacques Himber , Roland Humm , Hans Iding , Dietmar Knopp , Narendra Panday , Fabienne Ricklin , Christoph Martin Stahl
发明人: Markus Boehringer , Katrin Groebke Zbinden , Wolfgang Haap , Hans Hilpert , Jacques Himber , Roland Humm , Hans Iding , Dietmar Knopp , Narendra Panday , Fabienne Ricklin , Christoph Martin Stahl
IPC分类号: C07D413/02 , C07D401/02 , A61K31/44
CPC分类号: C07D213/64 , C07D213/75 , C07D233/64 , C07D279/02 , C07D295/135 , C07D295/185 , C07D401/12
摘要: The invention is concerned with novel dicarboxamide derivatives of formula (I) wherein A, B, Rc, D and E are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
摘要翻译: 本发明涉及式(I)的新型二甲酰胺衍生物,其中A,B,Rc,D和E如说明书和权利要求书中所定义,以及其生理上可接受的盐。 这些化合物抑制凝血因子Xa,并且可以用作药物。
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公开(公告)号:US07129238B2
公开(公告)日:2006-10-31
申请号:US10720790
申请日:2003-11-21
申请人: David William Banner , Luca Claudio Gobbi , Katrin Groebke Zbinden , Ulrike Obst , Christoph Martin Stahl
发明人: David William Banner , Luca Claudio Gobbi , Katrin Groebke Zbinden , Ulrike Obst , Christoph Martin Stahl
IPC分类号: A61K31/538 , A61K31/4402 , C07D211/98 , C07D235/12 , C07D207/08
CPC分类号: C07C257/18 , C07C259/18 , C07D211/46 , C07D213/30 , C07D213/38 , C07D213/56 , C07D213/65 , C07D213/73 , C07D231/12 , C07D233/56 , C07D239/42 , C07D249/08 , C07D265/36 , C07D271/06 , C07D295/15 , C07D309/12 , C07D311/04
摘要: The invention is concerned with novel mandelic acid derivatives of formula (I) wherein R1 to R10, X and Y are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit the formation of coagulation factors Xa, IXa and thrombin induced by factor VIIa and tissue factor.
摘要翻译: 本发明涉及式(I)的新型扁桃酸衍生物,其中R 1至R 10,X和Y如说明书和权利要求书中所定义,如 以及其药学上可接受的盐。 这些化合物抑制因子VIIa和组织因子诱导的凝血因子Xa,IXa和凝血酶的形成。
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公开(公告)号:US20100144762A1
公开(公告)日:2010-06-10
申请号:US12701769
申请日:2010-02-08
申请人: Konrad Bleicher , Simona Maria Ceccarelli , Odile Chomienne , Patrizio Mattei , Tanja Schulz-Gasch , Christoph Martin Stahl
发明人: Konrad Bleicher , Simona Maria Ceccarelli , Odile Chomienne , Patrizio Mattei , Tanja Schulz-Gasch , Christoph Martin Stahl
IPC分类号: A61K31/506 , C07C317/06 , C07C311/10 , C07D261/06 , C07D401/04 , C07D409/04 , A61K31/195 , A61K31/24 , A61K31/42 , A61K31/40 , A61P9/10 , A61P3/10 , A61P9/12
CPC分类号: C07D413/04 , C07C311/21 , C07C311/29 , C07D257/04 , C07D271/07 , C07D291/04 , C07D409/04
摘要: The invention is concerned with novel sulfonamide derivatives of formula (I) wherein R2, R3, R4, A, X, Y1, Y2, Y3, Y4 and Z1 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.
摘要翻译: 本发明涉及式(I)的新型磺酰胺衍生物,其中R2,R3,R4,A,X,Y1,Y2,Y3,Y4和Z1如说明书和权利要求书中所定义,以及生理上可接受的盐 及其酯。 这些化合物抑制L-CPT1,可用作药物。
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公开(公告)号:US07449581B2
公开(公告)日:2008-11-11
申请号:US11651302
申请日:2007-01-09
IPC分类号: C07D471/04
CPC分类号: C07D471/04 , C07D519/00
摘要: The present invention provides compounds of the Formula I and II: wherein R1, R3, W, Z, X1, X2, Ar1, R8 and R9 are as defined herein, and methods and intermediates for their preparation and uses thereof.
摘要翻译: 本发明提供式I和II的化合物:其中R 1,R 3,W,Z,X 1,X SUP > 2,其中R 1,R 8和R 9如本文所定义,并且其制备和用途的方法和中间体 其中。
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公开(公告)号:US07449472B2
公开(公告)日:2008-11-11
申请号:US11202611
申请日:2005-08-12
IPC分类号: A61K31/519 , A61P37/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D471/04 , C07D491/04 , A61K31/4355 , A61K31/4365 , A61K31/437
CPC分类号: C07D487/04 , C07D491/04 , C07D495/04
摘要: The present invention discloses compounds corresponding to the formula wherein A, X, Y, R, R1 and R2 are as defined within, pharmaceutical formulations, methods of making and uses thereof.
摘要翻译: 本发明公开了对应于下式的化合物:其中A,X,Y,R,R 1和R 2定义如下,药物制剂,制备和用途的方法 其中。
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公开(公告)号:US07439247B2
公开(公告)日:2008-10-21
申请号:US11292217
申请日:2005-11-30
IPC分类号: C07D471/04 , C07D491/048 , C07D495/04 , C07D487/04 , A61K31/519 , A61K31/4355 , A61K31/437
CPC分类号: C07D487/04 , C07D491/04 , C07D495/04
摘要: The present invention discloses compounds corresponding to formula wherein A, R, X, Y, R, R1 and R2 are as defined above, pharmaceutical formulations, methods of making and uses thereof.
摘要翻译: 本发明公开了相应于下式的化合物:其中A,R,X,Y,R,R 1和R 2如上所定义,药物制剂,制备方法和 其用途。
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公开(公告)号:US06696566B2
公开(公告)日:2004-02-24
申请号:US10073845
申请日:2002-02-11
IPC分类号: C07D47500
CPC分类号: C07D471/04 , C07D519/00
摘要: The present invention provides compounds of the Formula I and II: wherein R1, R3, W, Z, X1, X2, Ar1, R8 and R9 are as defined herein, and methods and intermediates for their preparation and uses thereof.
摘要翻译: 本发明提供式I和II的化合物:其中R 1,R 3,W,Z,X 1,X 2,Ar 1,R 8和R 9 >如本文所定义,以及其制备方法和中间体及其用途。
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公开(公告)号:US20110319438A1
公开(公告)日:2011-12-29
申请号:US13226697
申请日:2011-09-07
申请人: Konrad Bleicher , Simona Maria Ceccarelli , Odile Chomienne , Patrizio Mattei , Tanja Schulz-Gasch , Christoph Martin Stahl
发明人: Konrad Bleicher , Simona Maria Ceccarelli , Odile Chomienne , Patrizio Mattei , Tanja Schulz-Gasch , Christoph Martin Stahl
IPC分类号: A61K31/196 , C07C311/29 , C07D413/04 , C07D409/04 , C07D213/79 , C07D257/04 , A61K31/245 , A61K31/422 , A61K31/506 , A61K31/4155 , A61K31/44 , A61K31/41 , A61P3/10 , A61P3/04 , A61P9/12 , A61P3/06 , A61P3/00 , A61P9/10 , A61P9/04 , A61P1/16 , A61P13/12 , C07C311/21
CPC分类号: C07D413/04 , C07C311/21 , C07C311/29 , C07D257/04 , C07D271/07 , C07D291/04 , C07D409/04
摘要: The invention is concerned with novel sulfonamide derivatives of formula (I) wherein R2, R3, R4, A, X, Y1, Y2, Y3, Y4 and Z1 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.
摘要翻译: 本发明涉及式(I)的新型磺酰胺衍生物,其中R2,R3,R4,A,X,Y1,Y2,Y3,Y4和Z1如说明书和权利要求书中所定义,以及生理上可接受的盐 及其酯。 这些化合物抑制L-CPT1,可用作药物。
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公开(公告)号:US07723538B2
公开(公告)日:2010-05-25
申请号:US11444765
申请日:2006-06-01
申请人: Konrad Bleicher , Simona Maria Ceccarelli , Odile Chomienne , Patrizio Mattei , Tanja Schulz-Gasch , Christoph Martin Stahl
发明人: Konrad Bleicher , Simona Maria Ceccarelli , Odile Chomienne , Patrizio Mattei , Tanja Schulz-Gasch , Christoph Martin Stahl
IPC分类号: C07C63/04
CPC分类号: C07D413/04 , C07C311/21 , C07C311/29 , C07D257/04 , C07D271/07 , C07D291/04 , C07D409/04
摘要: The invention is concerned with novel sulfonamide derivatives of formula (I) wherein R2, R3, R4, A, X, Y1, Y2, Y3, Y4 and Z1 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.
摘要翻译: 本发明涉及式(I)的新型磺酰胺衍生物,其中R2,R3,R4,A,X,Y1,Y2,Y3,Y4和Z1如说明书和权利要求书中所定义,以及生理上可接受的盐 及其酯。 这些化合物抑制L-CPT1,可用作药物。
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