公开(公告)号：US06801311B1

公开(公告)日：2004-10-05

申请号：US09889908

申请日：2001-12-12

申请人： Günter Fuhr ,  Thomas Schnelle ,  Christoph Reichle ,  Henning Glasser ,  Torsten Müller

发明人： Günter Fuhr ,  Thomas Schnelle ,  Christoph Reichle ,  Henning Glasser ,  Torsten Müller

IPC分类号： G01N1502

CPC分类号： B03C5/028 ,  B03C5/026 ,  G01N15/1031 ,  G01N15/1056 ,  G01N15/1484 ,  G01N2015/1006 ,  G01N2015/105 ,  G01N2015/1075 ,  G01N2015/1415 ,  G01N2015/1447 ,  G01N2015/1495

摘要： For object detection, particularly in fluidic microsystems, optical imaging of at least one resting or moving object (10) on a structured mask (20) with at least one segment from a flat section (80), in which the object (10) is located at least partially or temporarily and which has a characteristic dimension smaller than the dimension of the object (10) or its movement path, to a detector unit, detection of the quantity of light transmitted by the structured mask (20), and generation of a detector signal which has a predetermined relationship with the quantity of light, and evaluation of the detector signal in regard to the presence of the object (10), its position, its shape and/or the temporal change of the position are performed.

摘要翻译： 对于物体检测，特别是在流体微系统中，至少一个静止或移动的物体（10）在结构化掩模（20）上的光学成像，其具有来自平坦部分（80）的至少一个部分，其中物体（10） 至少部分地或临时地定位，并且具有比物体（10）或其移动路径的尺寸小的特征尺寸，到检测器单元，由结构化掩模（20）传输的光量的检测，以及 执行与光量具有预定关系的检测器信号，以及关于物体（10）的存在，其位置，形状和/或位置的时间变化的检测器信号的评估。

公开(公告)号：US07501233B2

公开(公告)日：2009-03-10

申请号：US10416278

申请日：2001-11-09

申请人： Gabriele Gradl ,  Thomas Schnelle ,  Torsten Müller ,  Christoph Reichle

发明人： Gabriele Gradl ,  Thomas Schnelle ,  Torsten Müller ,  Christoph Reichle

IPC分类号： C12Q1/00

CPC分类号： G01N27/447 ,  G01N33/48735

摘要： A method is described for non-destructive measurement of vitality of biological cells, especially for determination of apoptosis, in which the at least one cell is exposed to high-frequency alternating, especially rotating, electric fields and/or impedance test fields, and at least one rotation measurement, one dielectrophoresis measurement and/or one impedance measurement is performed with the cell for at least one frequency range or individual frequencies, from which at least one measurement parameter is determined that is characteristic of the vitality state of the cell.

摘要翻译： 描述了一种用于非破坏性测量生物细胞的活力的方法，特别是用于确定细胞凋亡，其中至少一个细胞暴露于高频交替，特别是旋转的电场和/或阻抗测试领域，以及在 对于至少一个频率范围或单独的频率，用该小区执行至少一次旋转测量，一次介电电泳测量和/或一个阻抗测量，从该单元测量至少一个测量参数是该单元的活力状态的特征。