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公开(公告)号:US20180313743A1
公开(公告)日:2018-11-01
申请号:US15940698
申请日:2018-03-29
CPC分类号: G01N15/1434 , B01L3/502715 , B01L3/502761 , B01L2300/0645 , B01L2300/168 , G01N15/0806 , G01N15/1056 , G01N15/1436 , G01N15/147 , G01N21/0303 , G01N21/66 , G01N2015/0038 , G01N2015/0065 , G01N2015/03 , G01N2015/0846 , G01N2015/1006 , G01N2015/1452 , G01N2021/0325 , G01N2021/0346 , G01N2021/6482 , G01N2021/651
摘要: Particle detection cartridges are provided. Aspects of the particle detection cartridges according to certain embodiments include a sample input, a flow channel and a light channel, where the flow channel and light channel are coupled at a detection region such that only light from the detection region can propagate directly through the light channel to a detector. Systems including the cartridges, as well as methods for detecting particles in a sample with the subject particle detection cartridges/systems, are also described. Kits having one or more cartridges are also provided.
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公开(公告)号:US10082455B2
公开(公告)日:2018-09-25
申请号:US14758249
申请日:2013-12-27
发明人: Se Hyun Shin , Jeong Hoon Nam
IPC分类号: G01N15/10 , B01D15/38 , B01D15/34 , G01N30/76 , B01L3/00 , G01N30/60 , G01N15/02 , G01N30/02
CPC分类号: G01N15/1056 , B01D15/34 , B01D15/3866 , B01D15/3885 , B01L3/50273 , B01L2200/0652 , B01L2300/0816 , B01L2300/0867 , B01L2400/0436 , G01N15/02 , G01N30/6095 , G01N30/76 , G01N2015/1081 , G01N2030/027
摘要: The present invention related to an apparatus for separating micro-nano scale particles based on microfluidic chromatography using surface acoustic waves, comprising: a piezoelectric substrate; a pair of transducers, which are patterned on the piezoelectric substrate and generate surface acoustic waves when electric energy is applied to the piezoelectric substrate; a microfluidic chip, which is mounted on the piezoelectric substrate and include a microfluidic channel disposed between the pair of transducers, wherein a fluid including micro-nano scale particles flows in the microfluidic channel; and a detection unit, which detects micro-nano scale particles separated by the surface acoustic waves while the micro-nano scale particles pass through the microfluidic channel, wherein forces of the surface acoustic waves generated by the pair of transducers are formed in a direction opposite to a fluid flow to generate flow resistance to the micro-nano scale particles which flows in the microfluidic channel.
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公开(公告)号:US20180267021A1
公开(公告)日:2018-09-20
申请号:US15533277
申请日:2015-12-04
发明人: Subra SURESH , E. DU , Monica DIEZ SILVA , Ming DAO
CPC分类号: G01N33/5026 , B01L3/502761 , G01N15/10 , G01N15/1056 , G01N2015/1006 , G01N2015/105 , G01N2015/1075 , G01N2015/1495 , G01N2800/52
摘要: The invention in some aspects relates to high throughput methods and devices for evaluating mechanical, morphological, kinetic, rheological or hematological properties of cells, such as blood cells under regulated gas conditions. In some aspects, the invention relates to methods and devices for diagnosing and/or characterizing a condition or disease in a subject by measuring a property of a cell from the subject, under controlled gas conditions.
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公开(公告)号:US10012651B2
公开(公告)日:2018-07-03
申请号:US15169365
申请日:2016-05-31
发明人: Chris C Yu , Xuedong Du , He Yu
IPC分类号: G01N33/53 , G01N15/10 , G01N33/574 , G01N33/50 , B01L3/00 , C12Q1/68 , G01N1/34 , A61B5/07 , A61B5/145 , A61B10/00 , G01N1/40 , G01N15/14 , G01N33/487 , C12M1/34 , G01N33/543 , G01N15/00
CPC分类号: G01N33/574 , A61B5/07 , A61B5/14503 , A61B5/1451 , A61B5/14517 , A61B5/14528 , A61B5/14546 , A61B10/0041 , A61B2562/028 , A61B2562/12 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2200/0652 , B01L2200/0663 , B01L2200/0668 , B01L2300/0627 , B01L2300/0636 , B01L2300/0645 , B01L2300/0681 , B01L2300/0858 , B01L2300/0887 , B01L2300/123 , B01L2300/163 , B01L2400/0487 , C12Q1/68 , G01N1/34 , G01N1/4077 , G01N15/1056 , G01N15/1484 , G01N33/487 , G01N33/5091 , G01N33/54366 , G01N2001/4088 , G01N2015/0065 , G01N2015/1006 , G01N2015/1062 , G01N2015/1486
摘要: Among others, the present invention provides apparatus for interacting with a biological subject to detect circulating tumor cells therein, comprising one device for sending a signal to the biological subject and optionally receiving a response to the signal from the biological entity.
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公开(公告)号:US09952135B2
公开(公告)日:2018-04-24
申请号:US15006332
申请日:2016-01-26
申请人: E. I. SPECTRA, LLC
发明人: Harold E. Ayliffe
IPC分类号: G01N15/14 , H01J49/00 , G01N35/00 , G01N27/00 , B01L3/00 , G01N15/12 , G06F17/40 , G06F19/00 , B01L99/00 , G01N15/10 , G01N33/49
CPC分类号: G01N15/1404 , B01L3/502715 , B01L3/502761 , B01L99/00 , B01L2300/0645 , B01L2300/0874 , B01L2300/0887 , B01L2400/0487 , G01N15/1056 , G01N15/12 , G01N15/1209 , G01N15/1456 , G01N15/1463 , G01N27/00 , G01N33/49 , G01N35/00 , G01N2015/1037 , G01N2015/1062 , G01N2015/1087 , G01N2035/00306 , G06F17/40 , G06F19/00 , H01J49/0013 , H01J49/0022
摘要: A portable, stand-alone microfluidic interrogation device including a microprocessor and a touch-screen display. The touch-screen display can receive one or more user input to select a particular particle interrogation procedure, and subsequently show interrogation results. A microfluidic path extending through the interrogation device includes alignment structure that defines an interrogation zone in which particles carried in a fluid are urged toward single-file travel. Operable alignment structure may define sheath-, or non-sheath fluid flow. Desirably, a portion of the alignment structure is removable from the device in a tool-free procedure. The device may operate under the Coulter principle, and/or detect Stokes' shift phenomena, and/or other optically-based signal(s).
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公开(公告)号:US20180029033A1
公开(公告)日:2018-02-01
申请号:US15660616
申请日:2017-07-26
申请人: Ancera Corp.
发明人: Hur KOSER , G. Thomas ROTH , William M. SUTTER
CPC分类号: B01L3/502707 , B01D19/0031 , B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L2200/0652 , B01L2300/0627 , B01L2300/0681 , B01L2300/10 , B01L2400/043 , B01L2400/0487 , B01L2400/0622 , B01L2400/082 , B03C1/0335 , B03C1/288 , B03C1/32 , B03C2201/18 , B03C2201/20 , B03C2201/26 , B07B1/4636 , G01N15/1031 , G01N15/1056 , G01N21/6452 , G01N35/1097 , G01N2015/0065 , G01N2015/1006 , G01N2015/1081
摘要: The disclosed embodiments relate to method, system and apparatus for assay testing. In an exemplary embodiment, the disclosure relates to a cartridge for testing an assay. The cartridge includes a sample reservoir to receive a mixture of a plurality of target particles and a ferrofluidic solution; a capture region formed on the cartridge; a fluidic channel to communicate the mixture between the sample reservoir and the capture region; a magnetic ferrofluidic solution positioned inside the fluidic channel; and at least one pneumatic valve to communicate a quantity of the mixture from the sample reservoir. The magnetic ferrofluidic solution is excitable in response to an externally applied electromagnetic field to affect the ferrofluidic solution in the mixture.
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公开(公告)号:US20180011042A1
公开(公告)日:2018-01-11
申请号:US15545406
申请日:2015-01-30
CPC分类号: G01N27/06 , B01L3/502715 , B01L2200/0652 , B01L2300/023 , B01L2300/0645 , G01N15/1031 , G01N15/1056 , G01N2015/0065 , G01N2015/1006
摘要: A method of microfluidic detection can include detecting, using an impedance sensor, an impedance of a fluid to indicate whether a threshold amount of fluid has been received in a reservoir of a microfluidic chip. The method can include initiating a test performed by the microfluidic chip on the received fluid when the threshold amount of fluid has been received.
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公开(公告)号:US20170336396A1
公开(公告)日:2017-11-23
申请号:US15615568
申请日:2017-06-06
发明人: Chris C. Yu , Xuedong Du , He Yu
CPC分类号: G01N33/5091 , B01L3/502761 , B01L2200/0652 , B01L2200/0663 , B01L2200/0668 , B01L2300/0636 , B01L2300/0645 , B01L2400/0487 , G01N15/1056 , G01N15/1484 , G01N2015/0288 , G01N2015/1006 , G01N2035/00158 , Y10T436/143333
摘要: The present invention provides a method for detecting a disease at a very low concentration of diseased biological subject by contacting the diseased biological subject with a micro-device which comprises: a first sorting unit capable of directly detecting an intrinsic property of the biological subject at the microscopic level and sorting the biological subject by the detected intrinsic property; a first detection unit capable of detecting the same or different property of the sorted biological subject at the microscopic level; and a first layer of material having an exterior surface and an interior surface, wherein the interior surface defines a first channel in which the biological subject flows through the first sorting unit, and then the sorted biological subject flows from the first sorting unit to the first detection unit.
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公开(公告)号:US20170284922A1
公开(公告)日:2017-10-05
申请号:US15509203
申请日:2015-09-01
申请人: SELEXIS S.A.
发明人: Nicolas Mermod , Niamh Harraghy , Xuan Droz , Amar Rida , Pierre-Alain Girod , Alexandre Regamey , Thierry Colombet , Etienne Lancon
IPC分类号: G01N15/10 , G01N33/543 , B01L3/00 , C12N5/071 , G01N33/569 , G01N33/574
CPC分类号: G01N15/1056 , B01L3/502715 , B01L3/502723 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/023 , B01L2300/0681 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , C12M47/04 , C12N5/0682 , C12N2510/02 , G01N33/54326 , G01N33/54333 , G01N33/54366 , G01N33/56966 , G01N33/57492 , G01N2015/0065 , G01N2015/1006 , G01N2015/1081
摘要: The invention discloses a method for selecting cells depending on their level of displaying and preferably secreting a protein of interest from a population of heterogeneously expressing cells, comprising: (a) contacting said cells with magnetic beads coated with an affinity group to the said cells, (b) mixing the said magnetic beads with the cells to capture the cells displaying/secreting the protein of interest, (c) performing at least one washing step to remove the non-captured cells, and (d) recovering the cells to which that magnetic beads have bound.
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10.
公开(公告)号:US09770714B2
公开(公告)日:2017-09-26
申请号:US14848312
申请日:2015-09-08
发明人: Hiroshi Hamasaki , Michihiko Nishigaki , Yutaka Onozuka , Kentaro Kobayashi , Hiroko Miki , Naofumi Nakamura
IPC分类号: B01L3/00 , G01N33/487
CPC分类号: B01L3/5027 , B01L2200/0647 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0887 , B01L2400/0421 , B01L2400/086 , G01N15/1056 , G01N15/12 , G01N33/48707 , G01N33/4875 , G01N2015/1006
摘要: According to one embodiment, an analysis package including a board including an electrical terminal, an analysis chip provided at the board, the chip including a detector for detecting a particle, a flow channel of a sample liquid for particle detection to the detector, and a liquid receiver for introducing the sample liquid into the flow channel, a mold provided to cover the board on which the analysis chip is provided, the mold comprising an opening above the liquid receiver, a first shield layer provided on a back surface of the board, and a second shield layer provided to be attachable and detachable on an opposite side to the analysis chip of the mold, the second shield layer being electrically connected to a part of the electrical terminal.
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