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公开(公告)号：US20230241609A1
公开(公告)日：2023-08-03
申请号：US18010794
申请日：2020-06-17
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Jeffrey A. Nielsen , Viktor Shkolnikov , Erica Squires , Roberto A. Pugliese , Matthew D. Smith , Michael J. Day , Diane R. Hammerstad
CPC classification number: B01L3/502746 , G01N15/1031 , G01N15/1056 , B01L2300/0663 , B01L2400/08 , B01L2200/061 , B01L2200/027 , B01L2300/0867 , B01L2200/0647
Abstract: A method of detecting passage of a particle into a target location includes receiving a sample on a die including a microfluidic chamber, the microfluidic chamber including a microfluidic path coupling a reservoir to a foyer, and moving the sample from the reservoir to the foyer by firing a nozzle fluidically coupled to the foyer. The method further includes detecting passage of a particle of the sample from the reservoir to the foyer via a first sensor disposed within the microfluidic path, and detecting passage of the particle into the target location via a second sensor disposed between the first sensor and the nozzle. The method includes recording in a dispense map, an indication of whether the target location includes a single particle or multiple particles based on signals measured by the first sensor and the second sensor.
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公开(公告)号：US11708563B2
公开(公告)日：2023-07-25
申请号：US17688857
申请日：2022-03-07
Applicant: Cellino Biotech, Inc.
Inventor： Matthias Wagner , Suvi Aivio , Mariangela Amenduni , Catherine Pilsmaker , Arnaldo Pereira , Ananya Zutshi , Anthia Toure , Steven Nagle , Ozge Whiting , George Harb , Matthew Sullivan , Maya Berlin-Udi , Stefanie Morgan , Nick Seay , Sang Lee , Scott Luro
IPC: G06K9/00 , C12N5/074 , C12N5/00 , G06T7/00 , C12M1/00 , C12M3/00 , C12M1/34 , C12M1/36 , C12M1/12 , C12M1/06 , C12M1/26 , G01N15/10 , B01L3/00
CPC classification number: C12N5/0696 , B01L3/502715 , C12M23/14 , C12M23/22 , C12M23/26 , C12M23/28 , C12M23/42 , C12M23/44 , C12M23/48 , C12M25/06 , C12M27/02 , C12M29/02 , C12M33/00 , C12M33/12 , C12M41/12 , C12M41/26 , C12M41/44 , C12M41/46 , C12M41/48 , C12M47/04 , C12N5/0081 , G01N15/1056 , G06T7/0012 , G06T7/0016 , B01L2300/0663 , G01N2015/1006 , G06T2207/10056 , G06T2207/10064 , G06T2207/20081 , G06T2207/30024 , G06T2207/30072
Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.
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公开(公告)号：US11680247B2
公开(公告)日：2023-06-20
申请号：US17688859
申请日：2022-03-07
Applicant: Cellino Biotech, Inc.
Inventor： Matthias Wagner , Suvi Aivio , Mariangela Amenduni , Catherine Pilsmaker , Arnaldo Pereira , Ananya Zutshi , Anthia Toure , Steven Nagle , Ozge Whiting , George Harb , Matthew Sullivan , Maya Berlin-Udi , Stefanie Morgan , Nick Seay , Sang Lee , Scott Luro
IPC: G06K9/00 , C12N5/074 , C12N5/00 , G06T7/00 , C12M1/00 , C12M3/00 , C12M1/34 , C12M1/36 , C12M1/12 , C12M1/06 , C12M1/26 , G01N15/10 , B01L3/00
CPC classification number: C12N5/0696 , B01L3/502715 , C12M23/14 , C12M23/22 , C12M23/26 , C12M23/28 , C12M23/42 , C12M23/44 , C12M23/48 , C12M25/06 , C12M27/02 , C12M29/02 , C12M33/00 , C12M33/12 , C12M41/12 , C12M41/26 , C12M41/44 , C12M41/46 , C12M41/48 , C12M47/04 , C12N5/0081 , G01N15/1056 , G06T7/0012 , G06T7/0016 , B01L2300/0663 , G01N2015/1006 , G06T2207/10056 , G06T2207/10064 , G06T2207/20081 , G06T2207/30024 , G06T2207/30072
Abstract: Disclosed herein are platforms, systems, and methods including a cell culture system that includes a cell culture container comprising a cell culture, the cell culture receiving input cells, a cell imaging subsystem configured to acquire images of the cell culture, a computing subsystem configured to perform a cell culture process on the cell culture according to the images acquired by the cell imaging subsystem, and a cell editing subsystem configured to edit the cell culture to produce output cell products according to the cell culture process.
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公开(公告)号：US20230184661A1
公开(公告)日：2023-06-15
申请号：US17926621
申请日：2021-05-18
Inventor： Peter NIRMALRAJ
CPC classification number: G01N15/1056 , G01N1/36 , G01Q60/24 , G06T7/0012 , G01N2001/366 , G01N2015/0073
Abstract: An aspect of the invention relates to a method for detecting amyloid aggregates (40) in blood. The method comprises providing a blood sample (20) comprising one or more red blood cells and performing an analysis of a surface layer (22) of the blood sample (20) by an atomic force microscope (10) to detect amyloid aggregates on the surface of the red blood cells and to image detected amyloid aggregates. Further aspects relate to a corresponding atomic force microscope and a corresponding computer program product.
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公开(公告)号：US11668638B2
公开(公告)日：2023-06-06
申请号：US17650033
申请日：2022-02-04
Applicant: Georgia Tech Research Corporation
Inventor： Todd Sulchek , Alexander Alexeev , Bushra Tasadduq
CPC classification number: G01N15/1056 , B01L3/502761 , B01L3/502776 , G01N1/34 , G01N33/5005 , B01L2200/0652 , B01L2200/0668 , B01L2300/0877 , B01L2300/16 , B01L2400/086 , G01N2015/1006 , G01N2015/1081
Abstract: A microchannel for processing cells by compression of the cells including an inlet, ridges and an outlet. Each ridge including a compressive surface and a cell adhesion entity. The outlet configured to remove at least one of a first portion of the cells and a second portion of the cells from the microchannel. Each ridge oriented at an angle of from 25 degrees to 70 degrees relative to a center axis of the microchannel. The cell adhesion entity configured such that the first portion of the cells has a first adhesion property relative to the cell adhesion entity to follow a first trajectory through the microchannel. The cell adhesion entity further configured such that the second portion of the cells has a second adhesion property relative to the cell adhesion entity to follow a second trajectory through the microchannel. The first trajectory is different from the second trajectory.
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Patent Agency Ranking
公开(公告)号：US20230168174A1
公开(公告)日：2023-06-01
申请号：US17927622
申请日：2021-04-19
Inventor： Robert BLICK , Paul GWOZDZ , Udai Raj SINGH , Andreas GUSE , Lola HERNANDEZ , Björn-Philipp DIERCKS
CPC classification number: G01N15/1031 , G01N22/00 , G01N15/0266 , G01N15/1056 , G01N2015/0065
Abstract: Provided is a label-free, single biological cell dielectric spectroscopy method, including the steps of: translocating a biological cell through a micropore or channel embedded in a substrate and interfaced with a coplanar waveguide while the biological cell experiences at least one RF field of at least 700 MHz provided via an RF input port to the coplanar waveguide; performing a time domain measurement of at least one RF signal reflected from or transmitted to a device under test (DUT); and determining an amplitude change and a phase change based on the reflected or transmitted at least one RF signal due to the translocating biological cell to determine an internal state or a morphological state of the biological cell. Also disclosed herein are devices for performing the dielectric spectroscopy method.
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公开(公告)号：US11656167B2
公开(公告)日：2023-05-23
申请号：US16716369
申请日：2019-12-16
Applicant: Sphere Fluidics Limited
Inventor： Clive Adrian Smith , Xin Li , Frank F. Craig
CPC classification number: G01N15/1031 , B01L3/50273 , B01L3/502715 , B01L3/502784 , G01N15/1056 , G01N15/1404 , B01L2200/0652 , B01L2300/0627 , B01L2300/0816 , B01L2300/0864 , B01L2400/0424 , B01L2400/0427 , B01L2400/084 , G01N2015/1081 , G01N2015/149 , G01N2015/1486 , H01J49/0031 , H01J49/04
Abstract: A method for aligning sequences of droplets in streams of an emulsion comprising target droplets and tag droplets, a tag droplet comprising first and second tags. A target droplet is split into first and second target droplets and a tag droplet is split into first and second tag droplets. Each of the first and second tag droplets comprise the first and second tags. The first target droplet and first tag droplet are in a first stream of droplets, and the second target droplet and second tag droplet are in a second stream of droplets. The method detects the first tag droplets and first target droplets in the first stream and the second tag droplets and second target droplets in the second stream, determines a first sequence of droplets in the first stream and a second sequence of droplets in the second stream, and compares these to align the sequences.
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公开(公告)号：US20190240666A1
公开(公告)日：2019-08-08
申请号：US16382190
申请日：2019-04-11
Applicant: The Regents of the University of California
Inventor： Lydia L. Sohn , Junghyun Kim , Sewoon Han
IPC: B01L3/00 , G01N15/10 , G01N27/403 , G01N27/327
CPC classification number: B01L3/502761 , G01N15/1056 , G01N27/3275 , G01N27/403
Abstract: Mechano-node-pore sensing (mechano-NPS), is a rapid, multi-parametric cell screening method that simultaneously quantifies cell diameter, transit time through a contraction channel, transverse deformation under constant strain, and recovery time after deformation
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公开(公告)号：US20190210025A1
公开(公告)日：2019-07-11
申请号：US16099172
申请日：2016-07-26
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Chantelle DOMINGUE , Tod WOODFORD , Manish GIRI , Matthew David SMITH , George H CORRIGAN III , Masoud ZAVAREHI , Joshua M. YU
CPC classification number: B01L3/502761 , B01L3/502715 , B01L3/5085 , B01L2200/0652 , B01L2300/0645 , B01L2300/0864 , B01L2400/043 , B01L2400/0439 , B01L2400/0442 , G01N15/1031 , G01N15/1056 , G01N35/1065 , G01N2015/1006 , G01N2015/1062 , G01N2015/1081
Abstract: According to an example, a microfluidic apparatus may include a fluid slot and a foyer that is in fluid communication with the fluid slot via a channel having a relatively smaller width than the foyer. The microfluidic apparatus may also include an electrical sensor to measure a change in an electrical field caused by a particle of interest in a fluid passing through the channel from the fluid slot to the foyer, an actuator to apply pressure onto fluid contained in the foyer, and a controller to receive the measured change in the electrical field from the electrical sensor, determine, from the received change in the electrical field, an electrical signature of the particle of interest, and control the actuator to control movement of the particle of interest based upon the determined electrical signature of the particle of interest.
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10.发明申请公开(公告)号：US20190204204A1
公开(公告)日：2019-07-04
申请号：US15770399
申请日：2016-10-21
Applicant: Georgia Tech Research Corporation
Inventor： Ali Faith Sarioglu
CPC classification number: G01N15/1056 , B01L3/502761 , B01L2200/0652 , B01L2200/143 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , G01N15/1031 , G01N2015/1006
Abstract: Provided herein are coded fluid paths. Also provided herein are devices and systems containing one or more of the coded fluid paths. Also provided herein are methods of using the coded fluid paths, devices, and systems provided herein.
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