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公开(公告)号：US20200061196A1
公开(公告)日：2020-02-27
申请号：US16564322
申请日：2019-09-09
申请人： David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
发明人： David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
IPC分类号： A61K47/52 , A61K39/385 , A61K47/64 , A61K47/65 , A61K51/12 , B82Y30/00 , B82Y40/00 , C01B32/174 , A61K47/69 , C01B32/176
摘要： The present invention provides soluble single wall nanotube (SWNT) constructs functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereto. The targeting moiety and the payload molecules may be attached to the soluble SWNT via a DNA or other oligomer platform attached to the SWNT. These soluble SWNT constructs may comprise a radionuclide or contrast agent and as such are effective as diagnostic and therapeutic agents. Methods provided herein are to diagnosing or locating a cancer, treating a cancer, eliciting an immune response against a cancer or delivering an anticancer drug in situ via an enzymatic nanofactory using the soluble SWNT constructs.
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公开(公告)号：US10406236B2
公开(公告)日：2019-09-10
申请号：US15494974
申请日：2017-04-24
申请人： David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
发明人： David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
IPC分类号： A61K47/52 , A61K39/385 , A61K47/64 , A61K47/65 , A61K51/12 , B82Y30/00 , B82Y40/00 , C01B32/174 , C01B32/176 , A61K47/69 , B82Y5/00
摘要： The present invention provides soluble single wall nanotube (SWNT) constructs functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereto. The targeting moiety and the payload molecules may be attached to the soluble SWNT via a DNA or other oligomer platform attached to the SWNT. These soluble SWNT constructs may comprise a radionuclide or contrast agent and as such are effective as diagnostic and therapeutic agents. Methods provided herein are to diagnosing or locating a cancer, treating a cancer, eliciting an immune response against a cancer or delivering an anticancer drug in situ via an enzymatic nanofactory using the soluble SWNT constructs.
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公开(公告)号：US11564988B2
公开(公告)日：2023-01-31
申请号：US16564322
申请日：2019-09-09
申请人： David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
发明人： David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
IPC分类号： A61K47/52 , A61K39/385 , A61K47/64 , A61K47/65 , A61K51/12 , B82Y30/00 , B82Y40/00 , C01B32/174 , A61K47/69 , C01B32/176 , B82Y5/00
摘要： The present invention provides soluble single wall nanotube (SWNT) constructs functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereto. The targeting moiety and the payload molecules may be attached to the soluble SWNT via a DNA or other oligomer platform attached to the SWNT. These soluble SWNT constructs may comprise a radionuclide or contrast agent and as such are effective as diagnostic and therapeutic agents. Methods provided herein are to diagnosing or locating a cancer, treating a cancer, eliciting an immune response against a cancer or delivering an anticancer drug in situ via an enzymatic nanofactory using the soluble SWNT constructs.
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公开(公告)号：US09629927B2
公开(公告)日：2017-04-25
申请号：US14034503
申请日：2013-09-23
申请人： David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
发明人： David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
CPC分类号： A61K47/52 , A61K39/385 , A61K47/64 , A61K47/65 , A61K47/6925 , A61K51/1248 , A61K51/1275 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C01B32/174 , C01B32/176 , C01B2202/02 , C01B2202/28 , C01B2202/34 , C01B2202/36
摘要： The present invention provides soluble single wall nanotube (SWNT) constructs functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereto. The targeting moiety and the payload molecules may be attached to the soluble SWNT via a DNA or other oligomer platform attached to the SWNT. These soluble SWNT constructs may comprise a radionuclide or contrast agent and as such are effective as diagnostic and therapeutic agents. Methods provided herein are to diagnosing or locating a cancer, treating a cancer, eliciting an immune response against a cancer or delivering an anticancer drug in situ via an enzymatic nanofactory using the soluble SWNT constructs.
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公开(公告)号：US08540965B2
公开(公告)日：2013-09-24
申请号：US11989672
申请日：2006-07-31
申请人： David A. Scheinberg , Michael McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jón Njardarson , Mark Reid Philips
发明人： David A. Scheinberg , Michael McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jón Njardarson , Mark Reid Philips
IPC分类号： A61K49/00
CPC分类号： B82Y40/00 , A61K47/6925 , A61K51/1248 , B82Y5/00 , B82Y30/00 , C01B32/174 , C01B2202/02 , C01B2202/28 , C01B2202/34 , C01B2202/36
摘要： The present invention provides soluble single wall nanotube constructs functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereto. The targeting moiety and the payload molecules may be attached to the soluble single wall carbon nanotube via a DNA or other oligomer platform attached to the single wall carbon nanotube. These soluble single wall carbon nanotube constructs may comprise a radionuclide or contrast agent and as such are effective as diagnostic and therapeutic agents. Methods provided herein are to diagnosing or locating a cancer, treating a cancer, eliciting an immune response against a cancer or delivering an anticancer drug in situ via an enzymatic nanofactory using the soluble single wall carbon nanotube constructs.
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公开(公告)号：US07645454B2
公开(公告)日：2010-01-12
申请号：US11145002
申请日：2005-06-03
申请人： Samuel J. Danishefsky , Vadim Dudkin , Justin Miller , David A. Scheinberg , Christophe Antczak
发明人： Samuel J. Danishefsky , Vadim Dudkin , Justin Miller , David A. Scheinberg , Christophe Antczak
IPC分类号： A61K38/04
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K39/21 , A61K2039/55577 , A61K2039/6018 , A61K2039/6081 , A61K2039/627 , C07K9/00 , C07K16/3069 , C12N9/6445 , C12N2740/16122 , C12N2740/16134 , C12Y304/21077
摘要： The present invention provides compounds having formula (I): wherein W1, W2, R1, R3, R4, R2A and R2B are as defined herein. In another aspect, the invention provides an antibody or antibody fragment which binds specifically to a normal or transformed PSA glycan or glycopeptide of the invention.
摘要翻译： 本发明提供具有式（I）的化合物：其中W1，W2，R1，R3，R4，R2A和R2B如本文所定义。 另一方面，本发明提供了与本发明的正常或转化的PSA聚糖或糖肽特异性结合的抗体或抗体片段。
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公开(公告)号：US20060223744A1
公开(公告)日：2006-10-05
申请号：US11145002
申请日：2005-06-03
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K39/21 , A61K2039/55577 , A61K2039/6018 , A61K2039/6081 , A61K2039/627 , C07K9/00 , C07K16/3069 , C12N9/6445 , C12N2740/16122 , C12N2740/16134 , C12Y304/21077
摘要： The present invention provides compounds having formula (I): wherein W1, W2, R1, R3, R4, R2A and R2B are as defined herein. In another aspect, the invention provides an antibody or antibody fragment which binds specifically to a normal or transformed PSA glycan or glycopeptide of the invention.
摘要翻译： 本发明提供具有式（I）的化合物：其中W 1，W 2，R 1，R 3， >，R 4，R 2A和R 2B如本文所定义。 另一方面，本发明提供了与本发明的正常或转化的PSA聚糖或糖肽特异性结合的抗体或抗体片段。
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公开(公告)号：US20170297912A1
公开(公告)日：2017-10-19
申请号：US15494974
申请日：2017-04-24
申请人： David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
发明人： David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
IPC分类号： B82Y40/00 , B82Y30/00 , A61K39/385 , A61K51/12 , B82Y5/00
CPC分类号： A61K47/52 , A61K39/385 , A61K47/64 , A61K47/65 , A61K47/6925 , A61K51/1248 , A61K51/1275 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C01B32/174 , C01B32/176 , C01B2202/02 , C01B2202/28 , C01B2202/34 , C01B2202/36
摘要： The present invention provides soluble single wall nanotube (SWNT) constructs functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereto. The targeting moiety and the payload molecules may be attached to the soluble SWNT via a DNA or other oligomer platform attached to the SWNT. These soluble SWNT constructs may comprise a radionuclide or contrast agent and as such are effective as diagnostic and therapeutic agents. Methods provided herein are to diagnosing or locating a cancer, treating a cancer, eliciting an immune response against a cancer or delivering an anticancer drug in situ via an enzymatic nanofactory using the soluble SWNT constructs.
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公开(公告)号：US20140086831A1
公开(公告)日：2014-03-27
申请号：US14034503
申请日：2013-09-23
申请人： David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
发明人： David A. Scheinberg , Michael R. McDevitt , Christophe Antczak , Debjit Chattopadhyay , Rena May , Jon Njardarson , Mark Reid Phillips
IPC分类号： A61K47/48 , A61K51/12 , A61K39/385
CPC分类号： A61K47/52 , A61K39/385 , A61K47/64 , A61K47/65 , A61K47/6925 , A61K51/1248 , A61K51/1275 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C01B32/174 , C01B32/176 , C01B2202/02 , C01B2202/28 , C01B2202/34 , C01B2202/36
摘要： The present invention provides soluble single wall nanotube (SWNT) constructs functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereto. The targeting moiety and the payload molecules may be attached to the soluble SWNT via a DNA or other oligomer platform attached to the SWNT. These soluble SWNT constructs may comprise a radionuclide or contrast agent and as such are effective as diagnostic and therapeutic agents. Methods provided herein are to diagnosing or locating a cancer, treating a cancer, eliciting an immune response against a cancer or delivering an anticancer drug in situ via an enzymatic nanofactory using the soluble SWNT constructs.
摘要翻译： 本发明提供用多个靶向部分和连接到其上的多个一个或多个有效载体分子官能化的可溶性单壁纳米管（SWNT）构建体。 靶向部分和有效载体分子可以通过连接到SWNT的DNA或其它低聚物平台连接到可溶性SWNT上。 这些可溶性SWNT构建体可以包含放射性核素或造影剂，因此作为诊断和治疗剂是有效的。 本文提供的方法是诊断或定位癌症，治疗癌症，引发针对癌症的免疫应答或使用可溶性SWNT构建体通过酶促纳米酶原位递送抗癌药物。
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10.发明申请公开(公告)号：US20120071523A1
公开(公告)日：2012-03-22
申请号：US13318573
申请日：2010-05-05
IPC分类号： A61K31/427 , C07D307/77 , C07D405/10 , C07D409/06 , C07D407/10 , C07D417/12 , A61K31/343 , A61K31/4178 , A61K31/381 , A61K31/36 , A61K31/357 , C12N5/071 , A61P31/00 , A61P35/00 , C07D307/80
CPC分类号： C07D307/80
摘要： The instant invention provides novel benzofuran-4,5-diones and pharmaceutical compositions thereof useful for inhibiting PDF and for treating proliferative and infectious diseases. Compounds may be selective for eukaryotic (e.g., human) PDF or prokaryotic PDF.
摘要翻译： 本发明提供了用于抑制PDF和治疗增殖性和感染性疾病的新型苯并呋喃-4,5-二酮及其药物组合物。 化合物可能对真核（例如人）PDF或原核生物PDF有选择性。
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