公开(公告)号：US09829435B2

公开(公告)日：2017-11-28

申请号：US13433619

申请日：2012-03-29

Applicant: Meng Lu ,  Chun Ge ,  Brian T. Cunningham ,  Stephen Schulz

Inventor： Meng Lu ,  Chun Ge ,  Brian T. Cunningham ,  Stephen Schulz

IPC: G01N21/64 ,  H01S3/1055 ,  H01S5/14

CPC classification number: G01N21/6428 ,  G01N21/6458 ,  G01N2021/6421 ,  H01S3/1055 ,  H01S5/141 ,  H01S5/142

Abstract: A label-free biosensor detection arrangement incorporating an external cavity laser (ECL) includes a tunable lasing element (e.g. an antireflection coated laser diode or semiconductor optical amplifier) and a narrow bandwidth resonant reflectance filter as the wavelength-selective element for the tunable lasing element. A sample is deposited on the surface of the resonant reflectance filter containing a biological material. The wavelength emitted by the external cavity laser is continuously tunable by binding interactions between the biological material and the resonant reflectance filter or adsorption of the biological material present in the sample on resonant reflectance filter. The narrow bandwidth resonance reflectance filter can take the form of photonic crystal (PC), a Bragg stack, or a Brag fiber reflection filter.

公开(公告)号：US20120258549A1

公开(公告)日：2012-10-11

申请号：US13433619

申请日：2012-03-29

Applicant: Meng Lu ,  Chun Ge ,  Brian T. Cunningham ,  Stephen Schulz

Inventor： Meng Lu ,  Chun Ge ,  Brian T. Cunningham ,  Stephen Schulz

IPC: G01N21/75 ,  G01N21/64

CPC classification number: G01N21/6428 ,  G01N21/6458 ,  G01N2021/6421 ,  H01S3/1055 ,  H01S5/141 ,  H01S5/142

Abstract: A label-free biosensor detection arrangement incorporating an external cavity laser (ECL) includes a tunable lasing element (e.g. an antireflection coated laser diode or semiconductor optical amplifier) and a narrow bandwidth resonant reflectance filter as the wavelength-selective element for the tunable lasing element. A sample is deposited on the surface of the resonant reflectance filter containing a biological material. The wavelength emitted by the external cavity laser is continuously tunable by binding interactions between the biological material and the resonant reflectance filter or adsorption of the biological material present in the sample on resonant reflectance filter. The narrow bandwidth resonance reflectance filter can take the form of photonic crystal (PC), a Bragg stack, or a Brag fiber reflection filter.

Abstract translation: 包含外腔激光器（ECL）的无标签生物传感器检测装置包括可调谐激光元件（例如抗反射涂层激光二极管或半导体光放大器）和窄带谐振反射滤光器，作为可调谐激光元件的波长选择元件 。 将样品沉积在含有生物材料的共振反射滤光片的表面上。 外腔激光器发出的波长可以通过生物材料和谐振反射滤光片之间的结合相互作用或者在样品中存在于共振反射滤光片上的生物材料的吸附来连续调节。 窄带谐振反射滤波器可以采用光子晶体（PC），布拉格堆叠或布拉格光纤反射滤光片的形式。