External cavity laser biosensor arrangements

    公开(公告)号:US09829435B2

    公开(公告)日:2017-11-28

    申请号:US13433619

    申请日:2012-03-29

    IPC分类号: G01N21/64 H01S3/1055 H01S5/14

    摘要: A label-free biosensor detection arrangement incorporating an external cavity laser (ECL) includes a tunable lasing element (e.g. an antireflection coated laser diode or semiconductor optical amplifier) and a narrow bandwidth resonant reflectance filter as the wavelength-selective element for the tunable lasing element. A sample is deposited on the surface of the resonant reflectance filter containing a biological material. The wavelength emitted by the external cavity laser is continuously tunable by binding interactions between the biological material and the resonant reflectance filter or adsorption of the biological material present in the sample on resonant reflectance filter. The narrow bandwidth resonance reflectance filter can take the form of photonic crystal (PC), a Bragg stack, or a Brag fiber reflection filter.

    External cavity laser biosensor arrangements
    2.
    发明申请
    External cavity laser biosensor arrangements 有权
    外腔激光生物传感器布置

    公开(公告)号:US20120258549A1

    公开(公告)日:2012-10-11

    申请号:US13433619

    申请日:2012-03-29

    IPC分类号: G01N21/75 G01N21/64

    摘要: A label-free biosensor detection arrangement incorporating an external cavity laser (ECL) includes a tunable lasing element (e.g. an antireflection coated laser diode or semiconductor optical amplifier) and a narrow bandwidth resonant reflectance filter as the wavelength-selective element for the tunable lasing element. A sample is deposited on the surface of the resonant reflectance filter containing a biological material. The wavelength emitted by the external cavity laser is continuously tunable by binding interactions between the biological material and the resonant reflectance filter or adsorption of the biological material present in the sample on resonant reflectance filter. The narrow bandwidth resonance reflectance filter can take the form of photonic crystal (PC), a Bragg stack, or a Brag fiber reflection filter.

    摘要翻译: 包含外腔激光器(ECL)的无标签生物传感器检测装置包括可调谐激光元件(例如抗反射涂层激光二极管或半导体光放大器)和窄带谐振反射滤光器,作为可调谐激光元件的波长选择元件 。 将样品沉积在含有生物材料的共振反射滤光片的表面上。 外腔激光器发出的波长可以通过生物材料和谐振反射滤光片之间的结合相互作用或者在样品中存在于共振反射滤光片上的生物材料的吸附来连续调节。 窄带谐振反射滤波器可以采用光子晶体(PC),布拉格堆叠或布拉格光纤反射滤光片的形式。

    TOUCH PANEL SYSTEM AND METHOD FOR DISTINGUISHING MULTIPLE TOUCH INPUTS
    3.
    发明申请
    TOUCH PANEL SYSTEM AND METHOD FOR DISTINGUISHING MULTIPLE TOUCH INPUTS 审中-公开
    触摸面板系统和用于识别多个触摸输入的方法

    公开(公告)号:US20070236478A1

    公开(公告)日:2007-10-11

    申请号:US11765163

    申请日:2007-06-19

    IPC分类号: G06F3/041

    摘要: Touch panel systems and methods are disclosed that can distinguish temporally overlapping touch inputs from single touch inputs so that valid touch position coordinates can be determined. Touch panel systems and methods of the present invention can distinguish overlapping touches by comparing signal magnitudes to specified thresholds, by comparing the rates of change of signal magnitudes or measured positions to determined parameters, by locating the proximity a calculated location to icons or other such active areas, and the like. Because touch panel systems and methods of the present invention can discriminate single touches from double touches, they can be used in multiple user applications such as multiplayer games as well as in applications that may be subject to rapidly successive or overlapping touch inputs.

    摘要翻译: 公开了触摸面板系统和方法,其可以区分时间上重叠的触摸输入与单个触摸输入,从而可以确定有效的触摸位置坐标。 通过将信号幅度或测量位置的变化率与确定的参数进行比较,可以通过将计算出的位置定位到图标或其他这样的活动的位置而将本发明的触摸面板系统和方法通过将信号幅度与指定阈值进行比较来区分重叠触摸 区域等。 因为本发明的触摸屏系统和方法可以将双触摸的单触摸区分开,所以它们可以用于多个用户应用中,例如多人游戏以及可能经受快速连续或重叠的触摸输入的应用。

    Optimized grating based biosensor and substrate combination
    4.
    发明授权
    Optimized grating based biosensor and substrate combination 失效
    基于光栅优化的生物传感器和基板组合

    公开(公告)号:US07162125B1

    公开(公告)日:2007-01-09

    申请号:US11207442

    申请日:2005-08-18

    申请人: Stephen Schulz

    发明人: Stephen Schulz

    摘要: A grating-based biosensor is disclosed where the biosensor is constructed and arranged such that the grating lines of the sensor align with an optical axis of a birefringent substrate, so as to improve resonance peak uniformity. Methods of manufacturing biosensors to provide alignment of the grating lines with the optical axes of a birefringent substrate are also disclosed. One embodiment uses a grating master wafer to form a grating on a continuous web of substrate material. The grating master wafer is rotated relative to the web until the lines of the grating in the master wafer are in substantial alignment with the optical axis of the web. A UV curable material is applied to the wafer and cured in place to form the grating on the surface of the substrate web. With a web of some preferred materials, such as PET film, one need only determine the optical axis orientation once for a given web since the optical axis orientation is essentially constant along the length of the web.

    摘要翻译: 公开了一种基于光栅的生物传感器,其中生物传感器被构造和布置成使得传感器的光栅线与双折射衬底的光轴对准,以便改善谐振峰均匀性。 还公开了制造生物传感器以提供光栅线与双折射基板的光轴的对准的方法。 一个实施例使用光栅母晶片在基片材料的连续幅材上形成光栅。 光栅母晶片相对于幅材旋转,直到主晶片中的光栅线与幅材的光轴基本对准。 将可UV固化材料施加到晶片上并固化就位,以在基材网的表面上形成光栅。 使用诸如PET膜的一些优选材料的纤维网,由于光轴取向在纤维网的长度上基本上是恒定的,所以仅需要为给定纤维网确定一次光轴取向。

    Optimized grating based biosensor and substrate combination

    公开(公告)号:US20070047874A1

    公开(公告)日:2007-03-01

    申请号:US11591160

    申请日:2006-10-31

    申请人: Stephen Schulz

    发明人: Stephen Schulz

    IPC分类号: G02B6/34

    摘要: A grating-based biosensor is disclosed where the biosensor is constructed and arranged such that the grating lines of the sensor align with an optical axis of a birefringent substrate, so as to improve resonance peak uniformity. Methods of manufacturing biosensors to provide alignment of the grating lines with the optical axes of a birefringent substrate are also disclosed. One embodiment uses a grating master wafer to form a grating on a continuous web of substrate material. The grating master wafer is rotated relative to the web until the lines of the grating in the master wafer are in substantial alignment with the optical axis of the web. A UV curable material is applied to the wafer and cured in place to form the grating on the surface of the substrate web. With a web of some preferred materials, such as PET film, one need only determine the optical axis orientation once for a given web since the optical axis orientation is essentially constant along the length of the web.

    Optimized grating based biosensor and substrate combination

    公开(公告)号:US20060291779A1

    公开(公告)日:2006-12-28

    申请号:US11207442

    申请日:2005-08-18

    申请人: Stephen Schulz

    发明人: Stephen Schulz

    IPC分类号: G02B6/34

    摘要: A grating-based biosensor is disclosed where the biosensor is constructed and arranged such that the grating lines of the sensor align with an optical axis of a birefringent substrate, so as to improve resonance peak uniformity. Methods of manufacturing biosensors to provide alignment of the grating lines with the optical axes of a birefringent substrate are also disclosed. One embodiment uses a grating master wafer to form a grating on a continuous web of substrate material. The grating master wafer is rotated relative to the web until the lines of the grating in the master wafer are in substantial alignment with the optical axis of the web. A UV curable material is applied to the wafer and cured in place to form the grating on the surface of the substrate web. With a web of some preferred materials, such as PET film, one need only determine the optical axis orientation once for a given web since the optical axis orientation is essentially constant along the length of the web.

    MULTIFUNCTIONAL MULTILAYER OPTICAL FILM
    7.
    发明申请
    MULTIFUNCTIONAL MULTILAYER OPTICAL FILM 审中-公开
    多功能多层光学膜

    公开(公告)号:US20070091076A1

    公开(公告)日:2007-04-26

    申请号:US11563912

    申请日:2006-11-28

    申请人: Stephen Schulz

    发明人: Stephen Schulz

    IPC分类号: G09G5/00

    摘要: Optical component for use in a touch sensor and method of fabrication of same are disclosed. Optical component includes a multilayer optical film at least some layers of which are fabricated on the same manufacturing line and using the same manufacturing method. Each layer of the multilayer optical film is designed primarily to provide a desired associated property.

    摘要翻译: 公开了用于触摸传感器的光学部件及其制造方法。 光学部件包括多层光学膜,其至少一些层被制造在相同的生产线上并且使用相同的制造方法。 多层光学膜的每层主要设计成提供所需的相关性质。

    Biosensor substrate structure for reducing the effects of optical interference
    8.
    发明申请
    Biosensor substrate structure for reducing the effects of optical interference 失效
    用于降低光学干涉影响的生物传感器基板结构

    公开(公告)号:US20060291766A1

    公开(公告)日:2006-12-28

    申请号:US11207491

    申请日:2005-08-18

    IPC分类号: G02B6/00

    CPC分类号: G01N21/7743

    摘要: A biosensor substrate structure is provided that eliminates the effects of optical interference of light reflected from a substrate/air interface with light reflected by the biosensor's active surface by incorporating a roughened or “non-specular” surface on the lower surface of the substrate opposite the grating. One can generate a useful non-specular or “anti-interference” surface in a number of ways in accordance with this disclosure, including (1) by adding a coating of optically diffuse material, such as UV cured acrylate, to the sensor substrate, (2) etching or otherwise roughening the surface of the sensor substrate, or (3) applying a grating structure to the surface.

    摘要翻译: 提供一种生物传感器基板结构,其通过在与基板/空气界面相反的基板的下表面上并入粗糙或“非镜面”表面,从而消除由基板/空气界面反射的光与生物传感器的活性表面反射的光的光学干涉的影响 光栅。 根据本公开,可以以多种方式产生有用的非镜面或“抗干扰”表面,包括(1)通过将光学漫射材料如UV固化的丙烯酸酯涂层添加到传感器基底, (2)蚀刻或以其它方式粗糙化传感器基板的表面,或(3)将光栅结构施加到表面。