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1.发明申请公开(公告)号：US20200206520A1
公开(公告)日：2020-07-02
申请号：US15998898
申请日：2016-02-16
申请人： Chung Wah SIU , HEARTISANS LIMITED
发明人： Hin Wai LUI , Chung Wah SIU
摘要： A method of determining whether rapid pulse indicative of ventricular tachycardia (VT) or ventricular fibrillation (VF) requires electric shock to defibrillate the rapid pulse using blood flow as a robust indicator of blood pressure stability. Preferably, the blood flow monitor is an optical sensor capable of monitoring blood flow change the moment VT or VF has begun its onset.
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2.发明授权Compositions and methods for improving the functional efficacy of stem cell-derived cardiomyocytes 有权用于改善干细胞来源的心肌细胞功能功效的组合物和方法公开(公告)号：US09045731B2
公开(公告)日：2015-06-02
申请号：US12677790
申请日：2008-09-11
申请人： Ronald Li , Chung-wah Siu , Deborah K. Lieu , Jing Liu
发明人： Ronald Li , Chung-wah Siu , Deborah K. Lieu , Jing Liu
IPC分类号： C12N5/00 , C12N5/0735 , C12N5/077 , A61K35/12
CPC分类号： A61K35/545 , A61K35/12 , C12N5/0606 , C12N5/0657 , C12N9/14 , C12N2500/25 , C12N2500/33 , C12N2500/44 , C12N2501/115 , C12N2502/13 , C12N2503/02 , C12N2506/02 , C12N2510/00 , C12Y306/03008
摘要： This invention provides an isolated stem cell that has been modified to provide, enhance or contain the functional characteristics of the sarcoplasmic reticulum (SR). The isolated stem cells are modified in one or more of the following manners: by expressing a calcium channel protein; by expressing a calcium pump protein such as the sarcro/endoplasmic reticulum Ca2+-ATPase (SERCA) protein; by inhibiting or downregulating expression of the Na+/Ca+ exchanger (NCX) protein; by expressing a calcium handling protein; by expressing a transverse (t-tubule; and/or by expressing a transverse (t-tubule biogenic protein. After the cell has been modified, it may be expanded to a substantially homogenous population of these cells or alternatively, differentiated to a more mature cell type. Compositions containing these cells and population of cells are also provided by this invention. The cells and compositions can he used to regenerate cardiac tissue, improve cardiac function, restore action potential of cardiac tissue; and treat or prevent cardiac malfunction. These methods can be achieved by administering an effective amount of a cell or population of cells or tissue of this invention to a host in need thereof. The cells and population of cells can be used diagnostically to screen drug or other therapeutic candidates.
摘要翻译： 本发明提供了已被修饰以提供，增强或含有肌质网（SR）的功能特征的分离的干细胞。 分离的干细胞以一种或多种以下方式进行修饰：通过表达钙通道蛋白; 通过表达钙泵蛋白如sarcro /内质网Ca2 + -ATPase（SERCA）蛋白; 通过抑制或下调Na + / Ca +交换（NCX）蛋白的表达; 通过表达钙处理蛋白; 通过表达横向（t-小管;和/或通过表达横向（t-小管生物来源的蛋白质），在细胞被修饰之后，它可以扩展到这些细胞的基本均匀的群体，或者被分化成更成熟的 细胞类型包含这些细胞和细胞群的组合物也由本发明提供，细胞和组合物可用于再生心脏组织，改善心脏功能，恢复心脏组织的动作电位;以及治疗或预防心脏功能障碍。 可以通过将有效量的本发明的细胞或组织的细胞或组织施用于有需要的宿主来实现。细胞和细胞群可用于筛选药物或其它治疗候选物。
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3.发明申请Compositions and Methods for Improving the Functional Efficacy of Stem Cell-Derived Cardiomyocytes 有权提高干细胞衍生心肌细胞功能功能的组合物和方法公开(公告)号：US20120014924A1
公开(公告)日：2012-01-19
申请号：US12677790
申请日：2008-09-11
申请人： Ronald Li , Chung-wah Siu , Deborah K. Lieu , Jing Liu
发明人： Ronald Li , Chung-wah Siu , Deborah K. Lieu , Jing Liu
CPC分类号： A61K35/545 , A61K35/12 , C12N5/0606 , C12N5/0657 , C12N9/14 , C12N2500/25 , C12N2500/33 , C12N2500/44 , C12N2501/115 , C12N2502/13 , C12N2503/02 , C12N2506/02 , C12N2510/00 , C12Y306/03008
摘要： This invention provides an isolated stem cell modified to provide, enhance or contain the functional characteristics of the sarcoplasmic reticulum (SR) The isolated stem cells are modified by expressing a calcium channel protein, by expressing a calcium pump protein such as the sarcro/endoplasmic reticulum Ca2+-ATPase (SERCA) protein, by inhibiting or downregulating expression of the Na+/Ca2+ exchanger (NCX) protein, by expressing a calcium handling protein, by expressing a transverse (t)-tubule, and/or by expressing a transverse (t)-tubule biogenic protein The modified cells may be expanded to a substantially homogenous population of these cells or differentiated to a more mature cell type Compositions are also provided The cells and compositions can be administered to a host and used to regenerate cardiac tissue, improve cardiac function, restore action potential of cardiac tissue, and treat or prevent cardiac malfunction Use for diagnostic screening of therapeutic candidates is also provided
摘要翻译： 本发明提供了修饰以提供，增强或含有肌质网（SR）的功能特征的分离的干细胞。分离的干细胞通过表达钙通道蛋白质而被修饰，通过表达钙泵蛋白，例如sarcro /内质网 Ca2 + -ATPase（SERCA）蛋白，通过表达横向（t） - 管和/或通过表达横向（t） - 管来表达钙处理蛋白，抑制或下调Na + / Ca 2+交换（NCX）蛋白的表达 ） - 管生物基因蛋白修饰的细胞可以扩增到这些细胞的基本均匀的群体或分化成更成熟的细胞类型。还提供组合物。细胞和组合物可以施用于宿主并用于再生心脏组织，改善心脏 功能，恢复心脏组织的动作电位，以及治疗或预防心脏功能障碍用于治疗候选者的诊断筛查 提供
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