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    NUCLEIC ACID MOLECULES ENCODING ANTI-AMYLOID-BETA ANTIBODIES
    3.
    发明申请
    NUCLEIC ACID MOLECULES ENCODING ANTI-AMYLOID-BETA ANTIBODIES 审中-公开
    编码抗淀粉样蛋白抗体的核酸分子

    公开(公告)号：US20120288896A1

    公开(公告)日：2012-11-15

    申请号：US13558256

    申请日：2012-07-25

    申请人： Ruth Greferath ,  Andreas Muhs ,  Andrea Pfeifer ,  Claude Nicolau

    发明人： Ruth Greferath ,  Andreas Muhs ,  Andrea Pfeifer ,  Claude Nicolau

    IPC分类号： C12N15/13 ,  C12P21/02 ,  C12N5/10 ,  C12N1/21 ,  C12N15/63

    CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K2039/505 ,  G01N2333/4709 ,  A61K2300/00

    摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).

    摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉状蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供了包含高度特异性和高效抗体的新型方法和组合物，其具有特异性识别并结合来自一系列淀粉样蛋白质的特定表位的能力。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样斑块形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性病，包括但不限于神经障碍如阿尔茨海默病（AD）。

    METHODS OF TREATING AMYLOIDOSIS COMPRISING THE USE OF ANTI-AMYLOID BETA ANTIBODIES
    4.
    发明申请
    METHODS OF TREATING AMYLOIDOSIS COMPRISING THE USE OF ANTI-AMYLOID BETA ANTIBODIES 审中-公开
    治疗包含抗Aβ抗体的AMYLOIDOSIS的方法

    公开(公告)号：US20120244165A1

    公开(公告)日：2012-09-27

    申请号：US13461658

    申请日：2012-05-01

    申请人： Ruth Greferath ,  Andreas Muhs ,  Andrea Pfeifer ,  Claude Nicolau

    发明人： Ruth Greferath ,  Andreas Muhs ,  Andrea Pfeifer ,  Claude Nicolau

    IPC分类号： A61K39/395 ,  A61P25/28

    CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K2039/505 ,  G01N2333/4709 ,  A61K2300/00

    摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease.The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).

    摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供了包含高度特异性和高效抗体的新型方法和组合物，其具有特异性识别并结合来自一系列淀粉样蛋白质的特定表位的能力。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样斑块形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性病，包括但不限于神经障碍如阿尔茨海默病（AD）。

    ERYTHROPOLETIN COMPLEMENTATION OR REPLACEMENT
    6.
    发明申请
    ERYTHROPOLETIN COMPLEMENTATION OR REPLACEMENT 审中-公开
    ERYTHROPOLETIN补充或替代

    公开(公告)号：US20110294732A1

    公开(公告)日：2011-12-01

    申请号：US13176513

    申请日：2011-07-05

    申请人： Claude NICOLAU ,  Jean-Marie Lehn ,  Ruth Greferath

    发明人： Claude NICOLAU ,  Jean-Marie Lehn ,  Ruth Greferath

    IPC分类号： A61K31/665 ,  A61P7/06 ,  A61P7/00 ,  A61K38/18

    CPC分类号： A61K31/66 ,  A61K31/6615 ,  A61K35/15 ,  A61K38/1816 ,  A61K2300/00

    摘要： The present invention provides methods and compositions to replace up to 90% of erythropoietin use in the treatment of anemias and hypoxias. The method employs acid and salt forms of inositol-tripyrophosphate (ITPP) isomers to shift the P50 value of hemoglobin, thereby improving the rate and efficiency of oxygenation by blood even when red blood cell counts are low. Indications for the new method include anemias and hypoxia arising from infection, chemotherapy, premature birth, altitude change, compromised lung or heart function, aplastic anemia and anemia associated with a myelodysplastic syndrome, and other causes.

    摘要翻译： 本发明提供了用于替代高达90％的红细胞生成素用于治疗贫血和缺氧的方法和组合物。 该方法采用酸性和盐形式的肌醇三磷酸（ITPP）异构体来移动血红蛋白的P50值，从而即使红细胞计数低，也能提高血液氧合的速率和效率。 新方法的适应症包括感染，化疗，早产，高原变化，肺或心脏功能受损，再生障碍性贫血和与骨髓增生异常综合征相关的贫血引起的贫血和缺氧以及其他原因。

    Tumor eradication by inositol-tripyrophosphate
    7.
    发明申请
    Tumor eradication by inositol-tripyrophosphate 审中-公开
    通过肌醇三磷酸根除肿瘤

    公开(公告)号：US20070135389A1

    公开(公告)日：2007-06-14

    申请号：US11497566

    申请日：2006-08-01

    申请人： Claude Nicolau ,  Jean-Marie Lehn

    发明人： Claude Nicolau ,  Jean-Marie Lehn

    IPC分类号： A61K31/66 ,  C07F9/02

    CPC分类号： A61K31/6615 ,  A61K31/665 ,  C07F9/65746

    摘要： The present invention relates to various salts of inositol tripyrophosphate including the calcium, lithium, beryllium, magnesium, potassium, strontium, barium, rubidium and cesium salts of inositol tripyrophosphate, compositions comprising these salts, methods of making the various salts, and methods of use of the above salts. Methods of use include administering the above salts in an effective amount in individuals for the treatment of various types of cancers, Alzheimer's disease, stroke and osteoporosis.

    摘要翻译： 本发明涉及三水合磷酸肌醇的各种盐，包括三水合磷酸肌醇的钙，锂，铍，镁，钾，锶，钡，铷和铯盐，包含这些盐的组合物，制备各种盐的方法和使用方法 的上述盐。 使用方法包括在个体中施用有效量的上述盐用于治疗各种类型的癌症，阿尔茨海默氏病，中风和骨质疏松症。

    Calcium salt of myo-inositol 1,6:2,3:4,5 tripyrophosphate as an allosteric effector of hemoglobin
    8.
    发明申请
    Calcium salt of myo-inositol 1,6:2,3:4,5 tripyrophosphate as an allosteric effector of hemoglobin 审中-公开
    肌醇1,6：2,3：4,5三磷酸钙作为血红蛋白的变构效应物

    公开(公告)号：US20060241086A1

    公开(公告)日：2006-10-26

    申请号：US11384012

    申请日：2006-03-17

    申请人： Claude Nicolau ,  Jean-Marie Lehn ,  Konstantina Fylaktakidou ,  Ruth Greferath

    发明人： Claude Nicolau ,  Jean-Marie Lehn ,  Konstantina Fylaktakidou ,  Ruth Greferath

    IPC分类号： A61K31/66 ,  C07F9/02

    CPC分类号： C07F9/65746 ,  A61K31/6615

    摘要： The present invention relates to various salts of inositol tripyrophosphate including the calcium, lithium, beryllium, magnesium, potassium, strontium, barium, rubidium and cesium salts of inositol tripyrophosphate, compositions comprising these salts, methods of making the various salts, and methods of use of the above salts. Methods of use include administering the above salts in an effective amount in individuals for the treatment of various types of cancers, Alzheimer's disease, stroke and osteoporosis.

    摘要翻译： 本发明涉及三水合磷酸肌醇的各种盐，包括三水合磷酸肌醇的钙，锂，铍，镁，钾，锶，钡，铷和铯盐，包含这些盐的组合物，制备各种盐的方法和使用方法 的上述盐。 使用方法包括在个体中施用有效量的上述盐用于治疗各种类型的癌症，阿尔茨海默氏病，中风和骨质疏松症。

    Electro insertion of proteins into red cell membranes
    9.
    发明授权
    Electro insertion of proteins into red cell membranes 失效
    将蛋白质电插入红细胞膜

    公开(公告)号：US5236835A

    公开(公告)日：1993-08-17

    申请号：US809049

    申请日：1991-12-17

    申请人： Youssef Mouneimne ,  Pierre-Francois Tosi ,  Yves-Claude Nicolau

    发明人： Youssef Mouneimne ,  Pierre-Francois Tosi ,  Yves-Claude Nicolau

    IPC分类号： A61K9/50 ,  C12N5/00 ,  C12N13/00

    CPC分类号： C12N13/00 ,  A61K9/5068 ,  C12N5/0006

    摘要： A method of incorporating human CD4 or glycophorin into a red blood cell membrane is provided comprising exposing the red blood cell to an electric field while the cell is suspended in an electro-insertion medium in the presence of a buffered solution (suspension) of the proteins. These proteins bear a hydrophobic membrane spanning sequence. The resultant cell of the electro-insertion is then contacted with a resealing medium.

    摘要翻译： 提供将人CD4或血型糖蛋白掺入红细胞膜的方法，包括将红细胞暴露于电场，同时在蛋白质的缓冲溶液（悬浮液）存在的情况下将细胞悬浮于电插入介质中 。 这些蛋白质具有疏水膜跨越序列。 然后将所得的电插入细胞与再密封介质接触。