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1.发明申请CALCIUM/SODIUM SALT OF INOSITOL TRIPYROPHOSPHATE AS AN ALLOSTERIC EFFECTOR OF HEMOGLOBIN 审中-公开硝基磷酸三钙磷酸钙/钠盐作为HEMOGLOBIN的独立效应公开(公告)号：US20100029593A1
公开(公告)日：2010-02-04
申请号：US12554734
申请日：2009-09-04
CPC分类号： A61K31/6615 , A61K31/66 , C07F9/093
摘要： The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of inositol tripyrophosphate. Methods of use include administering the above salts in an effective amount to treat diseases caused by hypoxia or other conditions associated with inadequate function of the lungs or circulatory system, such as various types of cancer and Alzheimer's disease.
摘要翻译： 本发明涉及三水磷酸肌醇的混合钙/钠盐，其制备方法和使用方法。 混合的钙/钠盐可以是三磷酸肌醇的单钙四钠盐。 使用方法包括以有效量施用上述盐，以治疗由与肺或循环系统功能不足相关的缺氧或其它病症所引起的疾病，例如各种类型的癌症和阿尔茨海默氏病。
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公开(公告)号：US07618954B2
公开(公告)日：2009-11-17
申请号：US11328313
申请日：2006-01-09
IPC分类号： A61K31/663 , C07F9/02
CPC分类号： A61K31/6615 , A61K31/66 , A61K31/70 , A61K31/715 , A61K35/18 , C07F9/117 , C07F9/65746 , C07H15/207 , C12N5/0641
摘要： The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphospahte (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.
摘要翻译： 本发明包括化合物，其组合物和能够将包含内部焦磷酸盐环的改性肌醇六磷酸（IHP）递送至哺乳动物细胞的细胞质的方法。 在某些实施方案中，本发明涉及通过将IHP递送至红细胞的细胞质来增强哺乳动物红细胞传递氧的能力的化合物，其组合物和方法。
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3.发明申请CALCIUM/SODIUM SALT OF INOSITOL TRIPYROPHOSPHATE AS AN ALLOSTERIC EFFECTOR OF HEMOGLOBIN 审中-公开硝基磷酸三钙磷酸钙/钠盐作为HEMOGLOBIN的独立效应公开(公告)号：US20120010174A1
公开(公告)日：2012-01-12
申请号：US13176499
申请日：2011-07-05
IPC分类号： A61K31/6615 , A61P7/00 , A61P35/02 , A61P25/28 , C07F9/6574 , A61P35/00
CPC分类号： A61K31/661 , A61K31/6615 , C07F9/65746
摘要： The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of inositol tripyrophosphate. Methods of use include administering the above salts in an effective amount to treat diseases caused by hypoxia or other conditions associated with inadequate function of the lungs or circulatory system, such as various types of cancer and Alzheimer's disease.
摘要翻译： 本发明涉及三水磷酸肌醇的混合钙/钠盐，其制备方法和使用方法。 混合的钙/钠盐可以是三磷酸肌醇的单钙四钠盐。 使用方法包括以有效量施用上述盐，以治疗由与肺或循环系统功能不足相关的缺氧或其它病症所引起的疾病，例如各种类型的癌症和阿尔茨海默氏病。
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4.发明申请公开(公告)号：US20120003161A1
公开(公告)日：2012-01-05
申请号：US13212612
申请日：2011-08-18
IPC分类号： A61K31/6615 , A61K8/55 , A61P35/00 , A61K9/12
CPC分类号： A61K31/6615 , A61K9/0019
摘要： Inositol-tripyrophosphate is an allosteric effector of hemoglobin due to its ability to cross the plasma membrane of red blood cells and deliver oxygen to solid tumors, by lowering the oxygen affinity of the hemoglobin of red blood cells. The present invention is directed to the use of inositol-tripyrophosphate to reduce hemoglobin's affinity for oxygen in circulating red blood cells. The present invention is further directed to the use of inositol-tripyrophosphate to inhibit angiogenesis and enhance radiation sensitivity of hypoxic tumors. The present invention is further directed to the use of inositol-tripyrophosphate to enhance PO2 in hypoxic tumors.
摘要翻译： 肌醇三磷酸盐是血红蛋白的变构效应物，因为它能够通过降低红细胞血红蛋白的氧亲合力而穿过红细胞的质膜并将氧传递给实体瘤。 本发明涉及肌醇三磷酸降低血红蛋白在循环红细胞中对氧的亲和力的用途。 本发明还涉及肌醇三磷酸盐抑制血管发生和增强缺氧性肿瘤的放射敏感性的用途。 本发明还涉及肌醇三磷酸肌酸在缺氧性肿瘤中增强PO2的用途。
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公开(公告)号：US20060106000A1
公开(公告)日：2006-05-18
申请号：US11175979
申请日：2005-07-06
IPC分类号： A61K31/66
CPC分类号： A61K31/66
摘要： Inositol-tripyrophosphate is an allosteric effector of hemoglobin due to its ability to cross the plasma membrane of red blood cells and deliver oxygen to solid tumors, by lowering the oxygen affinity of the hemoglobin of red blood cells. The present invention is directed to the use of inositol-tripyrophosphate to reduce hemoglobin's affinity for oxygen in circulating red blood cells. The present invention is further directed to the use of inositol-tripyrophosphate to inhibit angiogenesis and enhance radiation sensitivity of hypoxic tumors. The present invention is further directed to the use of inositol-tripyrophosphate to enhance PO2 in hypoxic tumors.
摘要翻译： 肌醇三磷酸盐是血红蛋白的变构效应物，因为它能够通过降低红细胞血红蛋白的氧亲合力而穿过红细胞的质膜并将氧传递给实体瘤。 本发明涉及肌醇三磷酸降低血红蛋白在循环红细胞中对氧的亲和力的用途。 本发明还涉及肌醇三磷酸盐抑制血管发生和增强缺氧性肿瘤的放射敏感性的用途。 本发明还涉及肌醇三磷酸盐在缺氧性肿瘤中增强PO 2 N 2的用途。
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公开(公告)号：US08178514B2
公开(公告)日：2012-05-15
申请号：US13024922
申请日：2011-02-10
IPC分类号： A61K31/683 , A61P7/00 , A61P9/10
CPC分类号： A61K31/6615 , A61K31/66 , A61K31/70 , A61K31/715 , A61K35/18 , C07F9/117 , C07F9/65746 , C07H15/207 , C12N5/0641
摘要： The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphosphate (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.
摘要翻译： 本发明包括化合物，其组合物和能够将包含内部焦磷酸盐环的修饰的肌醇六磷酸（IHP）递送至哺乳动物细胞的细胞质的方法。 在某些实施方案中，本发明涉及通过将IHP递送至红细胞的细胞质来增强哺乳动物红细胞传递氧的能力的化合物，其组合物和方法。
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公开(公告)号：US20110294732A1
公开(公告)日：2011-12-01
申请号：US13176513
申请日：2011-07-05
申请人： Claude NICOLAU , Jean-Marie Lehn , Ruth Greferath
发明人： Claude NICOLAU , Jean-Marie Lehn , Ruth Greferath
IPC分类号： A61K31/665 , A61P7/06 , A61P7/00 , A61K38/18
CPC分类号： A61K31/66 , A61K31/6615 , A61K35/15 , A61K38/1816 , A61K2300/00
摘要： The present invention provides methods and compositions to replace up to 90% of erythropoietin use in the treatment of anemias and hypoxias. The method employs acid and salt forms of inositol-tripyrophosphate (ITPP) isomers to shift the P50 value of hemoglobin, thereby improving the rate and efficiency of oxygenation by blood even when red blood cell counts are low. Indications for the new method include anemias and hypoxia arising from infection, chemotherapy, premature birth, altitude change, compromised lung or heart function, aplastic anemia and anemia associated with a myelodysplastic syndrome, and other causes.
摘要翻译： 本发明提供了用于替代高达90％的红细胞生成素用于治疗贫血和缺氧的方法和组合物。 该方法采用酸性和盐形式的肌醇三磷酸（ITPP）异构体来移动血红蛋白的P50值，从而即使红细胞计数低，也能提高血液氧合的速率和效率。 新方法的适应症包括感染，化疗，早产，高原变化，肺或心脏功能受损，再生障碍性贫血和与骨髓增生异常综合征相关的贫血引起的贫血和缺氧以及其他原因。
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8.发明申请Calcium salt of myo-inositol 1,6:2,3:4,5 tripyrophosphate as an allosteric effector of hemoglobin 审中-公开肌醇1,6：2,3：4,5三磷酸钙作为血红蛋白的变构效应物公开(公告)号：US20060241086A1
公开(公告)日：2006-10-26
申请号：US11384012
申请日：2006-03-17
CPC分类号： C07F9/65746 , A61K31/6615
摘要： The present invention relates to various salts of inositol tripyrophosphate including the calcium, lithium, beryllium, magnesium, potassium, strontium, barium, rubidium and cesium salts of inositol tripyrophosphate, compositions comprising these salts, methods of making the various salts, and methods of use of the above salts. Methods of use include administering the above salts in an effective amount in individuals for the treatment of various types of cancers, Alzheimer's disease, stroke and osteoporosis.
摘要翻译： 本发明涉及三水合磷酸肌醇的各种盐，包括三水合磷酸肌醇的钙，锂，铍，镁，钾，锶，钡，铷和铯盐，包含这些盐的组合物，制备各种盐的方法和使用方法 的上述盐。 使用方法包括在个体中施用有效量的上述盐用于治疗各种类型的癌症，阿尔茨海默氏病，中风和骨质疏松症。
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9.发明申请公开(公告)号：US20120035137A1
公开(公告)日：2012-02-09
申请号：US13168728
申请日：2011-06-24
IPC分类号： A61K31/6615 , A61P35/02 , A61P35/04
CPC分类号： A61K31/66 , C07F9/65746
摘要： Inositol-tripyrophosphate is an allosteric effector of hemoglobin due to its ability to cross the plasma membrane of red blood cells and deliver oxygen to solid tumors, by lowering the oxygen affinity of the hemoglobin of red blood cells. The present invention is directed to the use of inositol-tripyrophosphate to reduce hemoglobin's affinity for oxygen in circulating red blood cells. The present invention is further directed to the use of inositol-tripyrophosphate to inhibit angiogenesis and enhance radiation sensitivity of hypoxic tumors. The present invention is further directed to the use of inositol-tripyrophosphate for the treatment of various types of cancers, Alzheimer's disease, stroke and osteoporosis.
摘要翻译： 肌醇三磷酸盐是血红蛋白的变构效应物，因为它能够通过降低红细胞血红蛋白的氧亲合力而穿过红细胞的质膜并将氧传递给实体瘤。 本发明涉及肌醇三磷酸降低血红蛋白在循环红细胞中对氧的亲和力的用途。 本发明还涉及肌醇三磷酸盐抑制血管发生和增强缺氧性肿瘤的放射敏感性的用途。 本发明还涉及肌醇三磷酸盐用于治疗各种类型的癌症，阿尔茨海默氏病，中风和骨质疏松症的用途。
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公开(公告)号：US20100256094A1
公开(公告)日：2010-10-07
申请号：US12646735
申请日：2009-12-23
IPC分类号： A61K31/683 , A61P3/10
CPC分类号： A61K31/6615 , A61K31/66 , A61K31/70 , A61K31/715 , A61K35/18 , C07F9/117 , C07F9/65746 , C07H15/207 , C12N5/0641
摘要： The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphospahte (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.
摘要翻译： 本发明包括化合物，其组合物和能够将包含内部焦磷酸盐环的改性肌醇六磷酸（IHP）递送至哺乳动物细胞的细胞质的方法。 在某些实施方案中，本发明涉及通过将IHP递送至红细胞的细胞质来增强哺乳动物红细胞传递氧的能力的化合物，其组合物和方法。
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