公开(公告)号：US20100286677A1

公开(公告)日：2010-11-11

申请号：US12792376

申请日：2010-06-02

申请人： John W. LEHMANN ,  Dan WITTENBERGER ,  Claudia LÜCKGE ,  Jean-Pierre LALONDE ,  Cristian PETRE ,  Domenic SANTOIANNI

发明人： John W. LEHMANN ,  Dan WITTENBERGER ,  Claudia LÜCKGE ,  Jean-Pierre LALONDE ,  Cristian PETRE ,  Domenic SANTOIANNI

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2017/00243 ,  A61B2017/00292 ,  A61B2017/00973 ,  A61B2018/00095 ,  A61B2018/0212 ,  A61F2007/0298 ,  A61M25/0029 ,  A61M2025/0039 ,  Y10S977/906

摘要： A cryogenic catheter includes an outer flexible member having at least one cryogenic fluid path through the flexible member. The at least one fluid path is defined by a plurality of flexible members disposed within the outer flexible member.

公开(公告)号：US07648497B2

公开(公告)日：2010-01-19

申请号：US11244710

申请日：2005-10-06

申请人： Miriam Lane ,  Leonilda Capuano ,  David Holtan ,  Jean-Pierre Lalonde ,  Claudia Lückge ,  Jean-Luc Pageard ,  Marwan Abboud ,  Johnny Al Asmar ,  Abderrahim Benrabah ,  Ken Chen ,  John W. Lehmann ,  Philippe Marchand ,  Robert Martin ,  Fredric L. Milder ,  Daniel Nahon

发明人： Miriam Lane ,  Leonilda Capuano ,  David Holtan ,  Jean-Pierre Lalonde ,  Claudia Lückge ,  Jean-Luc Pageard ,  Marwan Abboud ,  Johnny Al Asmar ,  Abderrahim Benrabah ,  Ken Chen ,  John W. Lehmann ,  Philippe Marchand ,  Robert Martin ,  Fredric L. Milder ,  Daniel Nahon

IPC分类号： A61B18/18

CPC分类号： A61B18/02 ,  A61B2017/22001 ,  A61B2017/22051 ,  A61B2017/22054 ,  A61B2017/22069 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/0268

摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. Various configurations, such as surface modification of the balloon interface, or placement of particles, coatings, or expandable meshes or coils in the balloon interface, may be employed to achieve this function.

摘要翻译： 具有远端球囊组件的细长导管装置适于血管内插入。 在不同的实施例中，通过装置注入的冷却剂可以直接冷却接触气囊的组织，或者可以冷却单独的内部腔室。 在第一种情况下，冷却剂还使气囊膨胀，并且废弃的冷却剂经由延伸穿过导管主体的返回通道返回到手柄。 可以提供多个气球，其中次级外球囊围绕主内球囊，主气球填充有冷却剂并用作冷却室，次级球囊联接到真空返回腔以用作鲁棒的泄漏容纳装置， 冷却室周围的绝热体。 可以采用各种构造，例如球囊界面的表面改性，或者在气球界面中放置颗粒，涂层或可膨胀的网孔或线圈，以实现该功能。

公开(公告)号：US06899709B2

公开(公告)日：2005-05-31

申请号：US10338274

申请日：2003-01-08

申请人： John W. Lehmann ,  Dan Wittenberger ,  Claudia Lückge ,  Jean-Pierre Lalonde ,  Cristian Petre ,  Domenic Santoianni

发明人： John W. Lehmann ,  Dan Wittenberger ,  Claudia Lückge ,  Jean-Pierre Lalonde ,  Cristian Petre ,  Domenic Santoianni

IPC分类号： A61B5/042 ,  A61B17/00 ,  A61B17/22 ,  A61B18/00 ,  A61B18/02 ,  A61F7/02 ,  A61M25/00 ,  A61B18/18 ,  A61F7/00

CPC分类号： A61M25/0029 ,  A61B5/042 ,  A61B18/02 ,  A61B2017/00243 ,  A61B2017/00292 ,  A61B2017/00973 ,  A61B2017/22051 ,  A61B2018/00095 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61F2007/0298 ,  A61M2025/0039 ,  Y10S977/906

摘要： A cryogenic catheter includes an outer flexible member having at least one cryogenic fluid path through the flexible member. The at least one fluid path is defined by a plurality of flexible members disposed within the outer flexible member.

摘要翻译： 低温导管包括具有穿过柔性构件的至少一个低温流体路径的外部柔性构件。 至少一个流体路径由设置在外部柔性构件内的多个柔性构件限定。

公开(公告)号：US06629972B2

公开(公告)日：2003-10-07

申请号：US09845535

申请日：2001-04-30

申请人： John W. Lehmann ,  Dan Wittenberger ,  Claudia Lückge ,  Jean-Pierre Lalonde ,  Cristian Petre ,  Domenic Santoianni

发明人： John W. Lehmann ,  Dan Wittenberger ,  Claudia Lückge ,  Jean-Pierre Lalonde ,  Cristian Petre ,  Domenic Santoianni

IPC分类号： A61B1818

CPC分类号： A61M25/0029 ,  A61B5/042 ,  A61B18/02 ,  A61B2017/00243 ,  A61B2017/00292 ,  A61B2017/00973 ,  A61B2017/22051 ,  A61B2018/00095 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61F2007/0298 ,  A61M2025/0039 ,  Y10S977/906

摘要： A cryogenic catheter includes an outer flexible member having at least one cryogenic fluid path through the flexible member. The at least one fluid path is defined by a plurality of flexible members disposed within the outer flexible member.

公开(公告)号：US06575966B2

公开(公告)日：2003-06-10

申请号：US09945319

申请日：2001-08-31

申请人： Miriam Lane ,  Leonilda Capuano ,  David Holtan ,  Jean-Pierre Lalonde ,  Claudia Lückge ,  Jean-Luc Pageard ,  Marwan Abboud ,  Johnny Al Asmar ,  Abderrahim Benrabah ,  Ken Chen ,  John W. Lehmann ,  Philippe Marchand ,  Robert Martin ,  Fredric L. Milder ,  Daniel Nahon

发明人： Miriam Lane ,  Leonilda Capuano ,  David Holtan ,  Jean-Pierre Lalonde ,  Claudia Lückge ,  Jean-Luc Pageard ,  Marwan Abboud ,  Johnny Al Asmar ,  Abderrahim Benrabah ,  Ken Chen ,  John W. Lehmann ,  Philippe Marchand ,  Robert Martin ,  Fredric L. Milder ,  Daniel Nahon

IPC分类号： A61B1818

CPC分类号： A61B18/02 ,  A61B2017/22001 ,  A61B2017/22051 ,  A61B2017/22054 ,  A61B2017/22069 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/0268

摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. Various configurations, such as surface modification of the balloon interface, or placement of particles, coatings, or expandable meshes or coils in the balloon interface, may be employed to achieve this function.

公开(公告)号：US06235019B1

公开(公告)日：2001-05-22

申请号：US09201071

申请日：1998-11-30

申请人： John W. Lehmann ,  Dan Wittenberger ,  Claudia Lückge ,  Jean-Pierre Lalonde ,  Cristian Petre ,  Domenic Santoianni

发明人： John W. Lehmann ,  Dan Wittenberger ,  Claudia Lückge ,  Jean-Pierre Lalonde ,  Cristian Petre ,  Domenic Santoianni

IPC分类号： A61B1818

CPC分类号： A61M25/0029 ,  A61B5/042 ,  A61B18/02 ,  A61B2017/00243 ,  A61B2017/00292 ,  A61B2017/00973 ,  A61B2017/22051 ,  A61B2018/00095 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61F2007/0298 ,  A61M2025/0039 ,  Y10S977/906

摘要： A cryogenic catheter having an elongate outer member and a plurality of inner members disposed within the elongate outer member is provided. The inner members define at least one cryogenic path through the outer member. At least one of the inner members has at least one controllable opening formed thereon to selectively release cryogenic fluid. The inner members also include an overtube and an injection tube slideably disposed to one another.

摘要翻译： 提供具有细长外部构件和设置在细长外部构件内的多个内部构件的低温导管。 内部构件限定穿过外部构件的至少一个低温路径。 至少一个内部构件具有形成在其上的至少一个可控开口以选择性地释放低温流体。 内部构件还包括可伸缩地彼此设置的外套管和注射管。

公开(公告)号：US20100286676A1

公开(公告)日：2010-11-11

申请号：US12791985

申请日：2010-06-02

申请人： John W. LEHMANN ,  Dan WITTENBERGER ,  Claudia LÜCKGE ,  Jean-Pierre LALONDE ,  Cristian PETRE ,  Domenic SANTOIANNI

发明人： John W. LEHMANN ,  Dan WITTENBERGER ,  Claudia LÜCKGE ,  Jean-Pierre LALONDE ,  Cristian PETRE ,  Domenic SANTOIANNI

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2017/00243 ,  A61B2017/00292 ,  A61B2017/00973 ,  A61B2018/00095 ,  A61B2018/0212 ,  A61F2007/0298 ,  A61M25/0029 ,  A61M2025/0039 ,  Y10S977/906

摘要： A cryogenic catheter includes an outer flexible member having at least one cryogenic fluid path through the flexible member. The at least one fluid path is defined by a plurality of flexible members disposed within the outer flexible member.

摘要翻译： 低温导管包括具有穿过柔性构件的至少一个低温流体路径的外部柔性构件。 至少一个流体路径由设置在外部柔性构件内的多个柔性构件限定。

公开(公告)号：US07300433B2

公开(公告)日：2007-11-27

申请号：US10397619

申请日：2003-03-26

申请人： Miriam Lane ,  Leonilda Capuano ,  David Holtan ,  Jean-Pierre Lalonde ,  Claudia Lückge ,  Jean-Luc Pageard ,  Marwan Abboud ,  Johnny Al Asmar ,  Abderrahim Benrabah ,  Ken Chen ,  John W. Lehmann ,  Philippe Marchand ,  Robert Martin ,  Fredric L. Milder ,  Daniel Nahon

发明人： Miriam Lane ,  Leonilda Capuano ,  David Holtan ,  Jean-Pierre Lalonde ,  Claudia Lückge ,  Jean-Luc Pageard ,  Marwan Abboud ,  Johnny Al Asmar ,  Abderrahim Benrabah ,  Ken Chen ,  John W. Lehmann ,  Philippe Marchand ,  Robert Martin ,  Fredric L. Milder ,  Daniel Nahon

IPC分类号： A61B18/18

CPC分类号： A61B18/02 ,  A61B2017/22001 ,  A61B2017/22051 ,  A61B2017/22054 ,  A61B2017/22069 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/0268

摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. Various configurations, such as surface modification of the balloon interface, or placement of particles, coatings, or expandable meshes or coils in the balloon interface, may be employed to achieve this function.

摘要翻译： 具有远端球囊组件的细长导管装置适于血管内插入。 在不同的实施例中，通过装置注入的冷却剂可以直接冷却接触气囊的组织，或者可以冷却单独的内部腔室。 在第一种情况下，冷却剂还使气囊膨胀，并且废弃的冷却剂经由延伸穿过导管主体的返回通道返回到手柄。 可以提供多个气球，其中次级外球囊围绕主内球囊，主气球填充有冷却剂并用作冷却室，次级球囊联接到真空返回腔以用作鲁棒的泄漏容纳装置， 冷却室周围的绝热体。 可以采用各种构造，例如球囊界面的表面改性，或者在气球界面中放置颗粒，涂层或可膨胀的网孔或线圈，以实现该功能。

公开(公告)号：US06913604B2

公开(公告)日：2005-07-05

申请号：US10346032

申请日：2003-01-16

申请人： Teresa Mihalik ,  Cristian Petre ,  Daniel Nahon ,  Steven G. Arless ,  Fredric L. Milder ,  Dan Wittenberger ,  Domenic N. Santoianni ,  Claudia Lückge ,  John W. Lehmann ,  Jean-Pierre Lalonde ,  Kenneth A. Spector

发明人： Teresa Mihalik ,  Cristian Petre ,  Daniel Nahon ,  Steven G. Arless ,  Fredric L. Milder ,  Dan Wittenberger ,  Domenic N. Santoianni ,  Claudia Lückge ,  John W. Lehmann ,  Jean-Pierre Lalonde ,  Kenneth A. Spector

IPC分类号： A61B17/00 ,  A61B18/00 ,  A61B18/02 ,  A61B19/00 ,  A61F7/02 ,  A61M25/00 ,  A61B18/18

CPC分类号： A61M25/0029 ,  A61B18/02 ,  A61B2017/00053 ,  A61B2017/00243 ,  A61B2017/00292 ,  A61B2017/00973 ,  A61B2018/00095 ,  A61B2018/00196 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2090/0463 ,  A61F2007/0298 ,  A61M2025/0037 ,  A61M2025/0039

摘要： A cryosurgical system including a housing having a front portion and a rear portion. The front portion and rear portion are connectable to support a fluid supply. A control unit attached to the front portion, and has a regulator assembly connecting the fluid supply to the control unit. A medical device is connected to the control unit, the medical device including a handle, a shaft, and a thermally-transmissive region. The handle, the shaft, and the thermally-transmissive region defining a fluid pathway through the handle, shaft, and thermally-transmissive region. The shaft is malleable to retain a first shape until manipulated to a second shape.

摘要翻译： 一种冷冻手术系统，包括具有前部和后部的壳体。 前部和后部可连接以支撑流体供应。 控制单元，其附接到前部，并且具有将流体供应连接到控制单元的调节器组件。 医疗设备连接到控制单元，医疗设备包括手柄，轴和热传导区域。 手柄，轴和透热区域限定通过手柄，轴和热透射区域的流体路径。 轴可延展以保持第一形状，直到操纵到第二形状。

公开(公告)号：US06595988B2

公开(公告)日：2003-07-22

申请号：US09887536

申请日：2001-06-22

申请人： Dan Wittenberger ,  Claudia Lückge ,  Sean Carroll

发明人： Dan Wittenberger ,  Claudia Lückge ,  Sean Carroll

IPC分类号： A61B1818

CPC分类号： A61B18/02 ,  A61B2017/00292 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262

摘要： A medical device for cryotreatment of bodily regions is disclosed. The device comprises an inflatable support structure coupled to the distal end portion of a catheter shaft, the support structure being further enveloped by an expandable membrane to define an expansion chamber between the support structure and the membrane. An inflation lumen is coupled to the support structure to inject an inert, insulating fluid in the support structure, thereby expanding the support structure and the expandable membrane, wherein the resultant expansion chamber formed therebetween is substantially conical in shape. Refrigerant is injected into the expansion chamber, thereby creating localized cooling of tissues adjacent to the expansion chamber, the cooling region being substantially conical in shape. Alternately, a second inflatable support structure is provided inside of the expandable membrane and distal to the first support structure, to define an expansion chamber therebetween that is substantially toroidal in shape, thereby enabling the creation of circumferential cooling regions when refrigerant is injected into said expansion chamber.