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公开(公告)号:US09129371B2
公开(公告)日:2015-09-08
申请号:US13507386
申请日:2012-06-25
CPC分类号: G06T11/60 , A61B5/0071 , A61B5/0075 , A61B5/7257 , G01N21/314 , G01N21/35 , G01N21/3581 , G01N2021/3595 , G06K9/00127 , G06T7/33 , G06T7/337 , G06T2207/10048 , G06T2207/10056 , G06T2207/20221 , G06T2207/30024 , G06T2207/30204
摘要: A method for registering a visual image and a spectral image of a biological sample includes aligning a first set of coordinate positions of a plurality of reticles on a slide holder and a second set of coordinate positions of the plurality of reticles on the slide holder. The method further includes generating a registered image of a visual image of a biological sample and a spectral image of the biological sample based upon the alignment of the first and second set of coordinate positions.
摘要翻译: 用于登记生物样本的视觉图像和光谱图像的方法包括将滑动保持器上的多个标线的第一组坐标位置与多个标线片的第二组坐标位置对准滑块保持器。 该方法还包括基于第一和第二组坐标位置的对准来生成生物样本的视觉图像的登记图像和生物样本的光谱图像。
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公开(公告)号:US09025850B2
公开(公告)日:2015-05-05
申请号:US13067777
申请日:2011-06-24
IPC分类号: G06K9/00 , G06T7/00 , G01N21/64 , G01N21/65 , G01N21/552 , G01V3/00 , A61B5/00 , G01N21/3581 , G01N21/35
CPC分类号: G01N21/31 , A61B5/0071 , A61B5/0075 , A61B5/415 , A61B5/418 , A61B5/7257 , G01N21/35 , G01N21/3581 , G01N21/552 , G01N21/6456 , G01N21/65 , G01N2021/3595 , G01N2021/6417 , G01N2021/653 , G01N2201/1293 , G01N2201/1296 , G06F19/00 , G06K9/00134 , G06K9/00147 , G06K2009/4657 , G06T7/30 , G06T2207/20101 , G06T2207/30024 , G16H50/20
摘要: A method for analyzing biological specimens by spectral imaging to provide a medical diagnosis includes obtaining spectral and visual images of biological specimens and registering the images to detect cell abnormalities, pre-cancerous cells, and cancerous cells. This method eliminates the bias and unreliability of diagnoses that is inherent in standard histopathological and other spectral methods. In addition, a method for correcting confounding spectral contributions that are frequently observed in microscopically acquired infrared spectra of cells and tissue includes performing a phase correction on the spectral data. This phase correction method may be used to correct various types of absorption spectra that are contaminated by reflective components.
摘要翻译: 通过光谱成像分析生物样本以提供医学诊断的方法包括获得生物标本的光谱和视觉图像并登记图像以检测细胞异常,癌前细胞和癌细胞。 该方法消除了标准组织病理学和其他光谱方法固有的诊断的偏倚和不可靠性。 此外,用于校正在细胞和组织的显微取得的红外光谱中经常观察到的混杂光谱贡献的方法包括对光谱数据执行相位校正。 该相位校正方法可用于校正被反射组件污染的各种类型的吸收光谱。
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公开(公告)号:US20120328178A1
公开(公告)日:2012-12-27
申请号:US13507386
申请日:2012-06-25
IPC分类号: G06K9/32
CPC分类号: G06T11/60 , A61B5/0071 , A61B5/0075 , A61B5/7257 , G01N21/314 , G01N21/35 , G01N21/3581 , G01N2021/3595 , G06K9/00127 , G06T7/33 , G06T7/337 , G06T2207/10048 , G06T2207/10056 , G06T2207/20221 , G06T2207/30024 , G06T2207/30204
摘要: A method for registering a visual image and a spectral image of a biological sample includes aligning a first set of coordinate positions of a plurality of reticles on a slide holder and a second set of coordinate positions of the plurality of reticles on the slide holder. The method further includes generating a registered image of a visual image of a biological sample and a spectral image of the biological sample based upon the alignment of the first and second set of coordinate positions.
摘要翻译: 用于登记生物样本的视觉图像和光谱图像的方法包括将滑动保持器上的多个标线的第一组坐标位置与多个标线片的第二组坐标位置对准滑块保持器。 该方法还包括基于第一和第二组坐标位置的对准来生成生物样本的视觉图像的登记图像和生物样本的光谱图像。
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