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公开(公告)号：US20110207939A1
公开(公告)日：2011-08-25
申请号：US13100058
申请日：2011-05-03
Applicant: Daniel A. Dickman , Dange Vijay Kumar , Colin O'Bryan , Roopa Rai , William Dvorak Shrader , Kieron Wesson
Inventor： Daniel A. Dickman , Dange Vijay Kumar , Colin O'Bryan , Roopa Rai , William Dvorak Shrader , Kieron Wesson
IPC: C07D235/12 , C07C69/76
CPC classification number: C07D235/18
Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
Abstract translation: 本发明涉及因子VIIa，IXa，Xa，XIa，特别是因子VIIa的新型抑制剂，包含这些抑制剂的药物组合物，以及使用这些抑制剂治疗或预防血栓栓塞性疾病，癌症或类风湿性关节炎的方法。 还公开了制备这些抑制剂的方法。
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公开(公告)号：US20130197229A1
公开(公告)日：2013-08-01
申请号：US13878412
申请日：2011-10-13
Applicant: Christopher Matthews , Colin O'Bryan , David Paul Provencal
Inventor： Christopher Matthews , Colin O'Bryan , David Paul Provencal
IPC: C07D471/04 , C07D309/06
CPC classification number: C07D471/04 , C07D309/06
Abstract: Disclosed are methods, reagents, and intermediates useful for making azaindazole derivatives, which may be used to modulate Glucokinase. The disclosed methods and materials are generally useful for making halo-esters and sulfonyl-substituted compounds.
Abstract translation: 公开了可用于制备可用于调节葡萄糖激酶的唑烷衍生物的方法，试剂和中间体。 公开的方法和材料通常可用于制备卤代酯和磺酰基取代的化合物。
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公开(公告)号：US08415328B2
公开(公告)日：2013-04-09
申请号：US13100058
申请日：2011-05-03
Applicant: Daniel A. Dickman , Dange Vijay Kumar , Colin O'Bryan , Roopa Rai , William Dvorak Shrader , Kieron Wesson
Inventor： Daniel A. Dickman , Dange Vijay Kumar , Colin O'Bryan , Roopa Rai , William Dvorak Shrader , Kieron Wesson
CPC classification number: C07D235/18
Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
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公开(公告)号：US20080275250A1
公开(公告)日：2008-11-06
申请号：US11597335
申请日：2005-06-02
Applicant: Daniel A. Dickman , Dange Vijay Kumar , Colin O'Bryan , Roopa Rai , William Dvorak Shrader , Kieron Wesson
Inventor： Daniel A. Dickman , Dange Vijay Kumar , Colin O'Bryan , Roopa Rai , William Dvorak Shrader , Kieron Wesson
IPC: C07D235/18
CPC classification number: C07D235/18
Abstract: The present invention relates to novel inhibitors or Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
Abstract translation: 本发明涉及新的抑制剂或因子VIIa，IXa，Xa，XIa，特别是因子VIIa，包含这些抑制剂的药物组合物，以及使用这些抑制剂治疗或预防血栓栓塞性疾病，癌症或类风湿性关节炎的方法。 还公开了制备这些抑制剂的方法。
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