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1.发明申请公开(公告)号：US20130157298A1
公开(公告)日：2013-06-20
申请号：US13607402
申请日：2012-09-07
申请人： Aleksandr Kolesnikov , Roopa Rai , William Dvorak Shrader , Steven M. Torkelson , Kieron E. Wesson , Wendy B. Young
发明人： Aleksandr Kolesnikov , Roopa Rai , William Dvorak Shrader , Steven M. Torkelson , Kieron E. Wesson , Wendy B. Young
IPC分类号： C12Q1/56
CPC分类号： C07D235/18 , C07D235/12 , C07D235/16 , C07D401/12 , C07D403/10 , C07F9/094 , C07F9/12 , C07F9/65128 , C12Q1/56
摘要： The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
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公开(公告)号：US20110207939A1
公开(公告)日：2011-08-25
申请号：US13100058
申请日：2011-05-03
申请人： Daniel A. Dickman , Dange Vijay Kumar , Colin O'Bryan , Roopa Rai , William Dvorak Shrader , Kieron Wesson
发明人： Daniel A. Dickman , Dange Vijay Kumar , Colin O'Bryan , Roopa Rai , William Dvorak Shrader , Kieron Wesson
IPC分类号： C07D235/12 , C07C69/76
CPC分类号： C07D235/18
摘要： The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
摘要翻译： 本发明涉及因子VIIa，IXa，Xa，XIa，特别是因子VIIa的新型抑制剂，包含这些抑制剂的药物组合物，以及使用这些抑制剂治疗或预防血栓栓塞性疾病，癌症或类风湿性关节炎的方法。 还公开了制备这些抑制剂的方法。
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公开(公告)号：US20100061960A1
公开(公告)日：2010-03-11
申请号：US12504184
申请日：2009-07-16
IPC分类号： A61K38/21 , C07D277/20 , A61K31/426 , C07D417/14 , A61K31/5377 , C07D413/14 , A61P31/12
CPC分类号： C07D417/12 , A61K31/426 , A61K31/5377 , A61K38/00 , C07D417/14
摘要： Disclosed are compounds, stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, their preparation, use, and compositions thereof for treating an infection mediated at least in part by a virus in the Flaviviridae family of viruses.
摘要翻译： 公开了化合物，立体异构体，互变异构体或其药学上可接受的盐，其制备，用途和组合物，用于治疗至少部分地由病毒在黄病毒科病毒中介导的感染。
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4.发明授权2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors 有权2-（2-羟基联苯-3-基）-1H-苯并咪唑-5-甲脒衍生物作为因子VIIA抑制剂公开(公告)号：US07479502B2
公开(公告)日：2009-01-20
申请号：US10537115
申请日：2003-12-03
申请人： Aleksandr Kolesnikov , Roopa Rai , William Dvorak Shrader , Steven M. Torkelson , Kieron E. Wesson , Wendy B. Young
发明人： Aleksandr Kolesnikov , Roopa Rai , William Dvorak Shrader , Steven M. Torkelson , Kieron E. Wesson , Wendy B. Young
IPC分类号： A61K31/4184 , C07D235/18
CPC分类号： C07D235/18 , C07D235/12 , C07D235/16 , C07D401/12 , C07D403/10 , C07F9/094 , C07F9/12 , C07F9/65128 , C12Q1/56
摘要： The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
摘要翻译： 本发明涉及因子VIIa，IXa，Xa，XIa，特别是因子VIIa的新型抑制剂，包含这些抑制剂的药物组合物，以及使用这些抑制剂治疗或预防血栓栓塞性疾病，癌症或类风湿性关节炎的方法。 还公开了制备这些抑制剂的方法。
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5.发明授权2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors 有权2-（2-羟基联苯-3-基）-1H-苯并咪唑-5-甲脒衍生物作为因子VIIa抑制剂公开(公告)号：US08299110B2
公开(公告)日：2012-10-30
申请号：US13100107
申请日：2011-05-03
申请人： Aleksandr Kolesnikov , Roopa Rai , William Dvorak Shrader , Steven M. Torkelson , Kieron E. Wesson , Wendy B. Young
发明人： Aleksandr Kolesnikov , Roopa Rai , William Dvorak Shrader , Steven M. Torkelson , Kieron E. Wesson , Wendy B. Young
IPC分类号： A61K31/4184
CPC分类号： C07D235/18 , C07D235/12 , C07D235/16 , C07D401/12 , C07D403/10 , C07F9/094 , C07F9/12 , C07F9/65128 , C12Q1/56
摘要： The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
摘要翻译： 本发明涉及因子VIIa，IXa，Xa，XIa，特别是因子VIIa的新型抑制剂，包含这些抑制剂的药物组合物，以及使用这些抑制剂治疗或预防血栓栓塞性疾病，癌症或类风湿性关节炎的方法。 还公开了制备这些抑制剂的方法。
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公开(公告)号：US20110044943A1
公开(公告)日：2011-02-24
申请号：US12668543
申请日：2008-07-11
申请人： Martin Robert Leivers , Jesse Daniel Keicher , Franz Ulrich Schmitz , Roopa Rai , Ryan Lauchli , Sebastian Reinhard Johannes Liehr , Stephanie Anna Chan , Tony Loc Ton
发明人： Martin Robert Leivers , Jesse Daniel Keicher , Franz Ulrich Schmitz , Roopa Rai , Ryan Lauchli , Sebastian Reinhard Johannes Liehr , Stephanie Anna Chan , Tony Loc Ton
IPC分类号： A61K38/21 , C07D487/04 , A61K31/5025 , A61P31/14 , A61K31/5377
CPC分类号： C07D487/04
摘要： Disclosed are compounds of Formula (I), pharmaceutically acceptable salts and solvates thereof, compositions thereof, and methods for their preparation and uses for treating viral infections mediated at least in part by a virus in the Flaviviridae family of viruses.
摘要翻译： 公开了式（I）的化合物，其药学上可接受的盐和溶剂合物，其组合物，及其制备方法和用于治疗至少部分地由病毒在黄病毒科病毒中介导的病毒感染的方法。
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7.发明申请N-(5-Membered Aromatic Ring)-Amido Anti-Viral Compounds 审中-公开N-（5-Membership Aromatic Ring）-Amido Anti-Viral Compounds公开(公告)号：US20100004441A1
公开(公告)日：2010-01-07
申请号：US12544273
申请日：2009-08-20
申请人： Franz Ulrich Schmitz , Christopher Don Roberts , Ali Dehghani Mohammad Abadi , Ronald Conrad Griffith , Martin Robert Leivers , Irina Slobodov , Roopa Rai
发明人： Franz Ulrich Schmitz , Christopher Don Roberts , Ali Dehghani Mohammad Abadi , Ronald Conrad Griffith , Martin Robert Leivers , Irina Slobodov , Roopa Rai
IPC分类号： C07D417/14 , C07D417/12 , C07D493/10
CPC分类号： C07D417/12 , C07D403/12 , C07D413/12 , C07D417/14 , C07D495/04 , C07D513/04
摘要： Disclosed are compounds having Formula (I) and the compositions and methods thereof for treating or preventing a viral infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R2, m, R, V, W, T, Z, R1, Y, and p are disclosed herein.
摘要翻译： 公开了具有式（I）的化合物及其组合物和方法，其用于治疗或预防病毒感染至少部分地由病毒在黄病毒科病毒中介导的病毒感染，其中A，R2，m，R，V，W，T ，Z，R1，Y和p。
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公开(公告)号：US20090226398A1
公开(公告)日：2009-09-10
申请号：US12397220
申请日：2009-03-03
申请人： Martin Robert Leivers , Christopher Don Roberts , Sebastian Johannes Reinhard Liehr , Stephanie Anna Chan , Roopa Rai , Ryan Lauchli , Son Minh Pham , Vivek Kumar Rajwanshi , Tony Loc Ton , Adam Christopher Villa
发明人： Martin Robert Leivers , Christopher Don Roberts , Sebastian Johannes Reinhard Liehr , Stephanie Anna Chan , Roopa Rai , Ryan Lauchli , Son Minh Pham , Vivek Kumar Rajwanshi , Tony Loc Ton , Adam Christopher Villa
IPC分类号： A61K38/21 , C07D487/02 , A61K31/5025 , C07D413/14 , A61K31/5377 , A61P31/12
CPC分类号： C07D487/04
摘要： Disclosed are compounds and compositions of Formula (I), pharmaceutically acceptable salts and solvates thereof, and their preparation and uses for treating viral infections mediated at least in part by a virus in the Flaviviridae family of viruses.
摘要翻译： 公开了式（I）的化合物和组合物，其药学上可接受的盐和溶剂合物，以及它们用于治疗至少部分地由病毒在黄病毒科病毒中介导的病毒感染的制备和用途。
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9.发明授权(Hetero)aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors 有权（杂芳基）双环杂芳基衍生物，它们的制备及其作为蛋白酶抑制剂的用途公开(公告)号：US06867200B1
公开(公告)日：2005-03-15
申请号：US09868276
申请日：1999-12-17
申请人： Darin A. Allen , Jason M. Hataye , Witold N. Hruzewicz , Aleksandr Kolesnikov , Richard L. Mackman , Roopa Rai , Spencer R. Jeffrey , Erik J. Verner , Wendy B. Young , William Dvorak Shrader
发明人： Darin A. Allen , Jason M. Hataye , Witold N. Hruzewicz , Aleksandr Kolesnikov , Richard L. Mackman , Roopa Rai , Spencer R. Jeffrey , Erik J. Verner , Wendy B. Young , William Dvorak Shrader
IPC分类号： A61K31/40 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/415 , A61K31/4184 , A61K31/425 , A61K31/427 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/5377 , A61K31/541 , A61K31/66 , A61P7/02 , A61P9/00 , A61P9/10 , A61P13/12 , A61P35/00 , A61P43/00 , C07D209/12 , C07D209/14 , C07D209/18 , C07D235/18 , C07D235/20 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D407/10 , C07D407/12 , C07D409/10 , C07D409/12 , C07D413/10 , C07D417/10 , C07D417/12 , C07D471/04 , C07D519/00 , C07F9/09 , A61K31/33 , C07D209/00 , C07D209/04
CPC分类号： C07D401/10 , C07D209/12 , C07D209/18 , C07D235/18 , C07D235/20 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D407/10 , C07D407/12 , C07D409/10 , C07D409/12 , C07D413/10 , C07D417/10 , C07D417/12 , C07D471/04
摘要： The present invention provides novel compounds of the Formula (I): A-B, its prodrug forms, or pharmaceutically acceptable salts thereof, wherein A represents a saturated, unsaturated, or a partially unsaturated bicyclic heterocyclic ring structure, and B represents an aryl or a heteroaryl group. Preferred compounds of the present invention comprise a benzimidazole or indole nucleus. The compounds of this invention are inhibitors of serine proteases, Urokinase (uPA), Factor Xa (FXa), and/or Factor VIIa (FVIIa), and have utility as anti cancer agents and/or as anticoagulants for the treatment or prevention of thromboembolic disorders in mammals.
摘要翻译： 本发明提供新的式（I）化合物：AB，其前药形式或其药学上可接受的盐，其中A表示饱和的，不饱和的或部分不饱和的双环杂环结构，B表示芳基或杂芳基 组。 本发明优选的化合物包括苯并咪唑或吲哚核。 本发明的化合物是丝氨酸蛋白酶，尿激酶（uPA），因子Xa（FXa）和/或因子VIIa（FVIIa）的抑制剂，并且可用作抗癌剂和/或抗凝剂用于治疗或预防血栓栓塞 哺乳动物疾病。
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公开(公告)号：US07595398B2
公开(公告)日：2009-09-29
申请号：US11609858
申请日：2006-12-12
申请人： Franz Ulrich Schmitz , Christopher Don Roberts , Ali Dehghani Mohammad Abadi , Ronald Conrad Griffith , Martin Robert Leivers , Irina Slobodov , Roopa Rai
发明人： Franz Ulrich Schmitz , Christopher Don Roberts , Ali Dehghani Mohammad Abadi , Ronald Conrad Griffith , Martin Robert Leivers , Irina Slobodov , Roopa Rai
IPC分类号： C07D417/12 , C07D417/14 , A61K31/427
CPC分类号： C07D417/12 , C07D403/12 , C07D413/12 , C07D417/14 , C07D495/04 , C07D513/04
摘要： Disclosed are compounds having Formula (I) and the compositions and methods thereof for treating or preventing a viral infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R2, m, R, V, W, T, Z, R1, Y, and p are disclosed herein.
摘要翻译： 公开了具有式（I）的化合物及其组合物和方法，其用于治疗或预防病毒感染至少部分地由病毒在黄病毒科病毒中介导的病毒感染，其中A，R2，m，R，V，W，T ，Z，R1，Y和p。
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