摘要:
Site-specific anti-body-drug conjugates are described, in particular conjugates comprising an antibody, which binds HER2 and comprises an amino acid substitution of an interchain cysteine residue by an amino acid that is not cysteine, and pyrrolobenzodiazepines (PBDs) having a labile protecting group in the form of a linker. The site of conjugation, along with modification of the antibody moiety, allows for improved safety and efficacy of the ADC.
摘要:
An intermediate symbol buffer (ISB) configuration and method is provided such that the ISB memory comprises 15 portions, one for each HSDPA spreading code. Symbols associated with a spreading code are written to the memory portion associated with the same spreading code. When a covariance calculation is performed to obtain a more accurate channel estimate, only the symbols associated with spreading codes determined to be needed for the covariance calculation are written to the ISB by a buffer block and red from the ISB by a correlation core. The symbols associated with spreading codes that are not necessary for a covariance calculation may be masked from being written or read from the ISB. In some embodiments each memory portion is an individual memory block. In other embodiments a plurality of memory blocks may contain a plurality of memory portions, one memory partition designated, at least temporarily, for each spreading code.
摘要:
An electric field object sensing system uses a charge pumping circuit to provide a voltage over a capacitor that varies dependent upon the capacitive coupling between a transmitter electrode and a receiver electrode. The output of the charge pump is preferably fed to a high impedance read-out means, such as an analog-digital converter (ADC). The system is preferably implemented in CMOS and integrated in control circuits of electronic products.
摘要:
The present invention relates to a display device with a birefringent lens system having cylindrical lenses, extending in a main direction. The polarisation of light modulated by a LC layer is twisted by a rotator layer (25′) in order to be perpendicular or parallel with this main direction. A birefringent compensation layer (26) is used to remove any ellipticity introduced by the rotator layer (25′). This provides improved contrast when the display device is used e.g. in a switchable 2D/3D display.
摘要:
An autostereoscopic display apparatus (8), comprising: a plurality of individually addressable display elements (2) arranged in an array of rows and columns; and light directing means (15) comprising a plurality of light directing elements (16) at a slant angle (α) to the column direction (6); wherein the shape of the individually addressable display elements (2) substantially comprises the shape remaining from a rectangular footprint when one or more cut-outs (2c) is removed; the one or more cut-outs (2c) being positioned relative to the slanted angle (α) of the light directing elements (16) such as to provide a reduction in brightness variation along the row direction (4) compared to what individually addressable display elements shaped according to the rectangular footprint would provide.
摘要:
The present invention relates to certain glucose-based compounds that have an affinity to P-selectin. Further, the invention relates to the use of these glucose-based compounds for the preparation of pharmaceutical compositions for the treatment of disorders associated with P-selectin, to conjugates, pharmaceutical carriers and drug delivery systems comprising said compounds, and to a method for determining whether a compound is capable of binding to P-selectin.
摘要:
Polyhydroxy phenols, which are non-peptidic mimetics of galloyl peptides, and a process for the preparation of gallic acid derivatives using a gallic-acid providing moiety are provided as well as polyhydroxy phenol-containing pharmaceutical and nutraceutical compositions. The use of polyhydroxy phenols as a medicament and especially for the manufacture of a medicament for the prevention, treatment or diagnosis of a disease or a condition, wherein P-selectin is involved, is provided. The same compounds can also be used as targeting tools to P-selectin expressing cells or tissues in a composition, further comprising an active compound in a vehicle.
摘要:
An electric field object sensing system (1) and method. The system (1) comprises a transmitter electrode (2), a receiver electrode (4), a switching circuit (32) coupled to the receiver electrode, an alternating voltage source (3) coupled to the transmitter electrode (2) and the switching circuit (32), and an output connection (34) coupled to the receiver electrode (4). Charge pumping performed according to the alternating voltage cycle provides a voltage over a capacitor (43) of the switching circuit (32) that increases dependent upon the capacitive coupling between the transmitter electrode (2) and the receiver electrode (4). The voltage over the capacitor (43) of the switching circuit (32) is allowed to saturate, and the saturated voltage is used as an output (20) that varies when an object (8) is in the vicinity of the transmitter and receiver electrodes. The output (20) may be fed to a high impedance read-out means e.g. an (24). The system (1) may be implemented in CMOS and integrated in control circuits of electronic products.
摘要:
The state transition of a linear feedback shift register (LFSR) controlled by a clock (310) with length N and step size W, W being at least two, is accomplished via a next-state function (320). The next-state function deploys a state transition matrix (350). The state vector (330), which represents the contents of the LFSR, is either multiplied sequentially by the state transition matrix or multiplied by the state transition matrix to the power of W (multiple state transition matrix). The method and the LFSR according to the invention are characterized in that the multiple state transition matrix is decomposed in a first matrix (360) and a second matrix (370), the first matrix comprising at most N+W+1 different expressions and the second matrix comprising at most N+W+1 different expressions. The LFSR further comprises means to multiply the state vector by the second matrix and the first matrix, and means for computing the first matrix. The invention overcomes the shortcomings of configurable multi-step linear feedback shift registers because the amount of time needed to generate the output can be reduced significantly.
摘要翻译:通过下一状态功能(320)实现由具有长度N和步长W,W至少为2的时钟(310)控制的线性反馈移位寄存器(LFSR)的状态转换。 下一状态函数部署状态转换矩阵(350)。 代表LFSR的内容的状态向量(330)被状态转移矩阵顺序相乘或乘以状态转移矩阵到W的幂(多状态转移矩阵)。 根据本发明的方法和LFSR的特征在于,多状态转移矩阵在第一矩阵(360)和第二矩阵(370)中被分解,第一矩阵包括至多N + W + 1个不同表达式,并且 第二矩阵包括至多N + W + 1个不同表达式。 LFSR还包括将状态向量乘以第二矩阵和第一矩阵的装置,以及用于计算第一矩阵的装置。 本发明克服了可配置的多级线性反馈移位寄存器的缺点,因为可以显着地减少产生输出所需的时间量。
摘要:
A combined passive and active object sensing system (30; 50; 70) employing electric field sensing is described. An electric field sensing transmission electrode (2) generates a first electric field (11, 12, 13) that induces a current in an electric field sensing reception electrode (4). A passive object (10) is sensed from variation in this current. An active object (31; 51; 71) comprises a further electric field sensing transmission electrode (33; 53; 73) and generates a second electric field (35, 36, 37; 55, 56, 57; 75, 76, 77). This may be generated by the active object (31) coupling with and applying a phase shift to the first electric field (11, 12, 13). Alternatively the second electric field (55, 56, 57) may be generated at a different frequency to the first electric field (11, 12, 13). Alternatively the second electric field (75, 76, 77) may be generated by the active object (71) coupling with an alternating magnetic field generated by a coil (172). The second electric field (35, 36, 37; 55, 56, 57; 75, 76, 77) induces a current in the electric field sensing reception electrode (4) that varies with the position of the active object (31; 51; 71). The separate currents are distinguished by virtue of their different phase or frequency.