公开(公告)号：US20080201122A1

公开(公告)日：2008-08-21

申请号：US11867658

申请日：2007-10-04

申请人： Scott D. Kelly ,  David J. Klinke ,  Clement Leong ,  Annette K. Lewis ,  Miles S. Okino ,  Thomas S. Paterson ,  Lisl K.M. Shoda ,  Cynthia Stokes ,  Herbert K. Struemper

发明人： Scott D. Kelly ,  David J. Klinke ,  Clement Leong ,  Annette K. Lewis ,  Miles S. Okino ,  Thomas S. Paterson ,  Lisl K.M. Shoda ,  Cynthia Stokes ,  Herbert K. Struemper

IPC分类号： G06G7/60

CPC分类号： G16H50/50 ,  G16B5/00

摘要： The present invention relates generally to a computer model of an adaptive immune response. One embodiment of the invention relates to a computer model of an adaptive immune response within the framework of signals conveyed at the site of antigen exposure. Another embodiment of the model includes a representation of complex physiological regulatory mechanisms related to, for example, cellular dynamics, mediator production, antigen-presenting cell (APC) recruitment, APC maturation, lymphocyte activation, lymphocyte trafficking, and/or lymphocyte effector function. In another embodiment, the model can account for mediator production in response to antigen within a chronically inflamed peripheral tissue, as well as the regulatory effects of mediators on APC and lymphocyte population dynamics, including maturation, activation, and apoptosis, and the regulatory effects of mediators produced by APCs and lymphocytes on a chronically inflamed peripheral tissue. Another embodiment of the invention relates to an analytical model of an adaptive immune response.

摘要翻译： 本发明一般涉及适应性免疫应答的计算机模型。 本发明的一个实施方案涉及在抗原暴露部位传递的信号框架内的适应性免疫应答的计算机模型。 该模型的另一实施方案包括与例如细胞动力学，介体产生，抗原呈递细胞（APC）募集，APC成熟，淋巴细胞活化，淋巴细胞运输和/或淋巴细胞效应子功能相关的复杂生理调节机制的表示。 在另一个实施方案中，模型可以解释响应于长期发炎的外周组织内的抗原的介体产生，以及介体对APC和淋巴细胞群体动力学的调节作用，包括成熟，活化和凋亡，以及调节作用 由APC和淋巴细胞在长期发炎的外周组织上产生的介质。 本发明的另一个实施方案涉及适应性免疫应答的分析模型。

公开(公告)号：US20080029110A1

公开(公告)日：2008-02-07

申请号：US11781604

申请日：2007-07-23

申请人： Michael Dube ,  Daniel Cantrell ,  John-Paul Mua ,  Darrell Holton ,  Cynthia Stokes ,  James Figlar

发明人： Michael Dube ,  Daniel Cantrell ,  John-Paul Mua ,  Darrell Holton ,  Cynthia Stokes ,  James Figlar

IPC分类号： A24B15/30 ,  A24B15/00 ,  A24F47/00

CPC分类号： A24B13/00 ,  A24B15/283

摘要： A smokeless tobacco product configured for insertion into the mouth of a user of the product is provided, the tobacco product including a water-permeable pouch containing a tobacco formulation, the tobacco formulation including a tobacco material and a plurality of microcapsules dispersed within the tobacco material, the plurality of microcapsules including an outer shell encapsulating an internal payload. The internal payload may include an additive such as water, flavorants, binders, colorants, pH adjusters, buffering agents, fillers, disintegration aids, humectants, antioxidants, oral care ingredients, preservatives, additives derived from herbal or botanical sources, and mixtures thereof. Microencapsulated flavorants include tobacco-containing flavorants, such as tobacco extracts or a particulate tobacco material, sweeteners (e.g., sweeteners containing neotame), and vanillin (optionally in a complexed form).

摘要翻译： 提供了构造成用于插入产品使用者的口中的无烟烟草产品，烟草制品包括含有烟草制剂的透水袋，烟草制剂包括烟草材料和分散在烟草材料内的多个微胶囊 ，所述多个微胶囊包括封装内部净荷的外壳。 内部有效载荷可以包括添加剂，例如水，调味剂，粘合剂，着色剂，pH调节剂，缓冲剂，填充剂，崩解助剂，保湿剂，抗氧化剂，口腔护理成分，防腐剂，来自草药或植物来源的添加剂，及其混合物。 微囊化香料包括含烟草的调味剂，例如烟草提取物或颗粒烟草材料，甜味剂（例如含有neotame的甜味剂）和香草醛（任选以络合形式）。

公开(公告)号：US20060124146A1

公开(公告)日：2006-06-15

申请号：US11351688

申请日：2006-02-10

申请人： Cynthia Stokes ,  Robert Powell ,  Brian Lawrence

发明人： Cynthia Stokes ,  Robert Powell ,  Brian Lawrence

IPC分类号： A24D1/02

CPC分类号： A24D1/025

摘要： Smokable rods of cigarettes are manufactured using wrapping materials that incorporate at least one fibrous material (e.g., flax fibers, hardwood pulp fibers and/or softwood pulp fibers) at least one filler material (e.g., calcium carbonate in particulate form). The wrapping materials possess multi-layer coatings. The wrapping materials include coatings in the form of series of spaced apart bands, each band having a series of layers. At least one of the coating layers can have a filler material dispersed or suspended within a film-forming material of that layer. Flavoring agent(s) are included in one or more of the wrapping material itself, a seam adhesive, and/or bands included on the wrapping material.

摘要翻译： 可吸烟的香烟棒使用包含至少一种纤维材料（例如亚麻纤维，硬木浆纤维和/或软木浆纤维）至少一种填充材料（例如颗粒形式的碳酸钙）的包装材料制造。 包装材料具有多层涂层。 包裹材料包括一系列间隔带形式的涂层，每个带具有一系列层。 涂层中的至少一层可以具有分散或悬浮在该层的成膜材料中的填料。 调味剂包括在包装材料本身，接缝粘合剂和/或包装材料中包含的带中的一种或多种中。