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    Method and Apparatus for Computer Modeling of an Adaptive Immune Response
    3.
    发明申请
    Method and Apparatus for Computer Modeling of an Adaptive Immune Response 审中-公开
    适应性免疫应答计算机建模方法与装置

    公开(公告)号：US20080201122A1

    公开(公告)日：2008-08-21

    申请号：US11867658

    申请日：2007-10-04

    申请人： Scott D. Kelly ,  David J. Klinke ,  Clement Leong ,  Annette K. Lewis ,  Miles S. Okino ,  Thomas S. Paterson ,  Lisl K.M. Shoda ,  Cynthia Stokes ,  Herbert K. Struemper

    发明人： Scott D. Kelly ,  David J. Klinke ,  Clement Leong ,  Annette K. Lewis ,  Miles S. Okino ,  Thomas S. Paterson ,  Lisl K.M. Shoda ,  Cynthia Stokes ,  Herbert K. Struemper

    IPC分类号： G06G7/60

    CPC分类号： G16H50/50 ,  G16B5/00

    摘要： The present invention relates generally to a computer model of an adaptive immune response. One embodiment of the invention relates to a computer model of an adaptive immune response within the framework of signals conveyed at the site of antigen exposure. Another embodiment of the model includes a representation of complex physiological regulatory mechanisms related to, for example, cellular dynamics, mediator production, antigen-presenting cell (APC) recruitment, APC maturation, lymphocyte activation, lymphocyte trafficking, and/or lymphocyte effector function. In another embodiment, the model can account for mediator production in response to antigen within a chronically inflamed peripheral tissue, as well as the regulatory effects of mediators on APC and lymphocyte population dynamics, including maturation, activation, and apoptosis, and the regulatory effects of mediators produced by APCs and lymphocytes on a chronically inflamed peripheral tissue. Another embodiment of the invention relates to an analytical model of an adaptive immune response.

    摘要翻译： 本发明一般涉及适应性免疫应答的计算机模型。 本发明的一个实施方案涉及在抗原暴露部位传递的信号框架内的适应性免疫应答的计算机模型。 该模型的另一实施方案包括与例如细胞动力学，介体产生，抗原呈递细胞（APC）募集，APC成熟，淋巴细胞活化，淋巴细胞运输和/或淋巴细胞效应子功能相关的复杂生理调节机制的表示。 在另一个实施方案中，模型可以解释响应于长期发炎的外周组织内的抗原的介体产生，以及介体对APC和淋巴细胞群体动力学的调节作用，包括成熟，活化和凋亡，以及调节作用 由APC和淋巴细胞在长期发炎的外周组织上产生的介质。 本发明的另一个实施方案涉及适应性免疫应答的分析模型。