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    Method and apparatus for conducting linked simulation operations utilizing a computer-based system model
    1.
    发明授权
    Method and apparatus for conducting linked simulation operations utilizing a computer-based system model 有权
    利用基于计算机的系统模型进行链接模拟操作的方法和装置

    公开(公告)号：US07165017B2

    公开(公告)日：2007-01-16

    申请号：US11248706

    申请日：2005-10-11

    申请人： Thomas S. Paterson ,  Alex L. Bangs

    发明人： Thomas S. Paterson ,  Alex L. Bangs

    IPC分类号： G06F9/45

    CPC分类号： G16H50/50 ,  G06F19/00 ,  G06F19/324 ,  G06F19/325

    摘要： A method of conducting a sequence of linked simulation operations, utilizing a computer-based simulation model, commences with the performance of a first simulation operation to generate an output condition. A further simulation operation, which is defined to sequentially follow the first simulation operation, is then formed utilizing the simulation model. The second simulation operation at least partially and automatically inherits the output condition generated by the first simulation operation as an input condition. In this way, the second simulation operation commences with a configuration captured from a preceding simulation operation as an input condition. Multiple simulation operations may at least partially inherit a configuration from the first simulation operation.

    摘要翻译： 利用基于计算机的仿真模型进行连接的仿真操作的序列的方法开始于执行第一模拟操作以产生输出条件。 然后利用仿真模型形成进一步的模拟操作，其被定义为顺序地遵循第一模拟操作。 第二模拟操作至少部分地且自动地将由第一模拟操作产生的输出条件继承为输入条件。 以这种方式，第二模拟操作以从先前的模拟操作捕获的配置作为输入条件开始。 多个模拟操作可以至少部分地从第一模拟操作继承配置。

    Apparatus and Method for Validating a Computer Model
    2.
    发明申请
    Apparatus and Method for Validating a Computer Model 有权
    用于验证计算机模型的装置和方法

    公开(公告)号：US20090132219A1

    公开(公告)日：2009-05-21

    申请号：US12208141

    申请日：2008-09-10

    申请人： Thomas S. PATERSON

    发明人： Thomas S. PATERSON

    IPC分类号： G06G7/60

    CPC分类号： G06F19/12 ,  G06F9/44505 ,  G06F17/5009 ,  G06F19/00 ,  G16H50/50

    摘要： An apparatus and method for validating a computer model is described. In one embodiment, a computer-readable medium comprises instructions to associate a set of configurations of a computer model with a stimulus-response test, each configuration of the set of configurations representing a different model scenario, the stimulus-response test defining a modification to each configuration of the set of configurations. The computer-readable medium also comprises instructions to apply the stimulus-response test to the set of configurations to produce a simulated response for each configuration of the set of configurations and instructions to compare the simulated responses for the set of configurations with an expected response to the stimulus-response test.

    摘要翻译： 描述了用于验证计算机模型的装置和方法。 在一个实施例中，计算机可读介质包括将计算机模型的一组配置与刺激 - 响应测试相关联的指令，所述一组配置的每个配置表示不同的模型场景，所述刺激 - 响应测试定义了对 每个配置的一组配置。 所述计算机可读介质还包括将所述刺激响应测试应用于所述一组配置的指令，以针对所述一组配置和指令的每个配置产生模拟响应，以将所述一组配置的模拟响应与预期响应 刺激反应测试。

    Method of generating a display for a dynamic simulation model utilizing node and link representations
    4.
    发明授权
    Method of generating a display for a dynamic simulation model utilizing node and link representations 失效

    公开(公告)号：US6051029A

    公开(公告)日：2000-04-18

    申请号：US962524

    申请日：1997-10-31

    申请人： Thomas S. Paterson ,  Samuel Holtzman ,  Alex L. Bangs

    发明人： Thomas S. Paterson ,  Samuel Holtzman ,  Alex L. Bangs

    IPC分类号： G06F19/00 ,  G06F9/44 ,  G06F9/455

    CPC分类号： G06F8/34 ,  G06F8/38

    摘要： A method of generating a display, or representation, of a simulation model within a graphical user interface (GUI) is described. The simulation model includes a number of objects, which may include state, function, link and modifier objects. The method commences with the display of node representations for at least first and second objects. Thereafter, a link representation, which represents an underlying link object, is selected from a predefined set of link representations to represent a desired relationship condition between the first and second objects. Each link representation of the set is associated with a distinct relationship condition. Each relationship condition may further be defined in terms of an underlying equation. Thereafter, the selected link representation is shown to extend between the respective node representations representing the first and second objects. Thus, the type of relationship condition which exists between the first and second objects is apparent from the link representation which extends between the relevant node representations.

    Simulating Patient-Specific Outcomes
    5.
    发明申请
    Simulating Patient-Specific Outcomes 审中-公开
    模拟患者特异性结果

    公开(公告)号：US20090150134A1

    公开(公告)日：2009-06-11

    申请号：US12269852

    申请日：2008-11-12

    申请人： Hector De Leon ,  Kapil Gadkar ,  Ananth Kadambi ,  Thomas S. Paterson ,  Lyn Powell

    发明人： Hector De Leon ,  Kapil Gadkar ,  Ananth Kadambi ,  Thomas S. Paterson ,  Lyn Powell

    IPC分类号： G06G7/60

    CPC分类号： G16H40/20

    摘要： The invention encompasses systems, methods, and apparatus for predicting clinical outcomes and monitoring an individual's response to a therapeutic regimen. The invention further encompasses methods for predicting cardiovascular risk based a genetic marker status and methods for modifying a computer to reflect genetic data and for incorporating genetic markers into a virtual population.

    摘要翻译： 本发明包括用于预测临床结果并监测个体对治疗方案的反应的系统，方法和装置。 本发明还包括基于遗传标记状态预测心血管风险的方法和用于修改计算机以反映遗传数据并将遗传标记并入虚拟群体的方法。

    Method and Apparatus for Computer Modeling of an Adaptive Immune Response
    7.
    发明申请
    Method and Apparatus for Computer Modeling of an Adaptive Immune Response 审中-公开
    适应性免疫应答计算机建模方法与装置

    公开(公告)号：US20080201122A1

    公开(公告)日：2008-08-21

    申请号：US11867658

    申请日：2007-10-04

    申请人： Scott D. Kelly ,  David J. Klinke ,  Clement Leong ,  Annette K. Lewis ,  Miles S. Okino ,  Thomas S. Paterson ,  Lisl K.M. Shoda ,  Cynthia Stokes ,  Herbert K. Struemper

    发明人： Scott D. Kelly ,  David J. Klinke ,  Clement Leong ,  Annette K. Lewis ,  Miles S. Okino ,  Thomas S. Paterson ,  Lisl K.M. Shoda ,  Cynthia Stokes ,  Herbert K. Struemper

    IPC分类号： G06G7/60

    CPC分类号： G16H50/50 ,  G16B5/00

    摘要： The present invention relates generally to a computer model of an adaptive immune response. One embodiment of the invention relates to a computer model of an adaptive immune response within the framework of signals conveyed at the site of antigen exposure. Another embodiment of the model includes a representation of complex physiological regulatory mechanisms related to, for example, cellular dynamics, mediator production, antigen-presenting cell (APC) recruitment, APC maturation, lymphocyte activation, lymphocyte trafficking, and/or lymphocyte effector function. In another embodiment, the model can account for mediator production in response to antigen within a chronically inflamed peripheral tissue, as well as the regulatory effects of mediators on APC and lymphocyte population dynamics, including maturation, activation, and apoptosis, and the regulatory effects of mediators produced by APCs and lymphocytes on a chronically inflamed peripheral tissue. Another embodiment of the invention relates to an analytical model of an adaptive immune response.

    摘要翻译： 本发明一般涉及适应性免疫应答的计算机模型。 本发明的一个实施方案涉及在抗原暴露部位传递的信号框架内的适应性免疫应答的计算机模型。 该模型的另一实施方案包括与例如细胞动力学，介体产生，抗原呈递细胞（APC）募集，APC成熟，淋巴细胞活化，淋巴细胞运输和/或淋巴细胞效应子功能相关的复杂生理调节机制的表示。 在另一个实施方案中，模型可以解释响应于长期发炎的外周组织内的抗原的介体产生，以及介体对APC和淋巴细胞群体动力学的调节作用，包括成熟，活化和凋亡，以及调节作用 由APC和淋巴细胞在长期发炎的外周组织上产生的介质。 本发明的另一个实施方案涉及适应性免疫应答的分析模型。

    Method and apparatus for conducting linked simulation operations utilizing a computer-based system model
    8.
    发明授权
    Method and apparatus for conducting linked simulation operations utilizing a computer-based system model 失效
    利用基于计算机的系统模型进行链接模拟操作的方法和装置

    公开(公告)号：US06983237B2

    公开(公告)日：2006-01-03

    申请号：US09814536

    申请日：2001-03-21

    申请人： Thomas S. Paterson ,  Alex L. Bangs

    发明人： Thomas S. Paterson ,  Alex L. Bangs

    IPC分类号： G06F9/455

    CPC分类号： G16H50/50 ,  G06F19/00 ,  G06F19/324 ,  G06F19/325

    摘要： A method of conducting a sequence of linked simulation operations, utilizing a computer-based simulation model, commences with the performance of a first simulation operation to generate an output condition. A further simulation operation, which is defined to sequentially follow the first simulation operation, is then formed utilizing the simulation model. The second simulation operation at least partially and automatically inherits the output condition generated by the first simulation operation as an input condition. In this way, the second simulation operation commences with a configuration captured from a preceding simulation operation as an input condition. Multiple simulation operations may at least partially inherit a configuration from the first simulation operation.

    摘要翻译： 利用基于计算机的仿真模型进行连接的仿真操作的序列的方法开始于执行第一模拟操作以产生输出条件。 然后利用仿真模型形成进一步的模拟操作，其被定义为顺序地遵循第一模拟操作。 第二模拟操作至少部分地且自动地将由第一模拟操作产生的输出条件继承为输入条件。 以这种方式，第二模拟操作以从先前的模拟操作捕获的配置作为输入条件开始。 多个模拟操作可以至少部分地从第一模拟操作继承配置。

    Method of generating a display for a dynamic simulation model utilizing node and link representations
    9.
    发明授权
    Method of generating a display for a dynamic simulation model utilizing node and link representations 失效
    使用节点和链接表示生成用于动态模拟模型的显示的方法

    公开(公告)号：US06539347B1

    公开(公告)日：2003-03-25

    申请号：US09588855

    申请日：2000-06-06

    申请人： Thomas S. Paterson ,  Samuel Holtzman ,  Alex L. Bangs

    发明人： Thomas S. Paterson ,  Samuel Holtzman ,  Alex L. Bangs

    IPC分类号： G06F9455

    CPC分类号： G06F8/38 ,  G06F8/34

    摘要： A method of generating a display, or representation, of a simulation model within a graphical user interface (GUI) is described. The simulation model includes a number of objects, which may include state, function, link and modifier objects. The method commences with the display of node representations for at least first and second objects. Thereafter, a link representation, which represents an underlying link object, is selected from a predefined set of link representations to represent a desired relationship condition between the first and second objects. Each link representation of the set is associated with a distinct relationship condition. Each relationship condition may further be defined in terms of an underlying equation. Thereafter, the selected link representation is shown to extend between the respective node representations representing the first and second objects. Thus, the type of relationship condition which exists between the first and second objects is apparent from the link representation which extends between the relevant node representations.

    摘要翻译： 描述了在图形用户界面（GUI）内生成模拟模型的显示或表示的方法。 模拟模型包括许多对象，其可以包括状态，功能，链接和修饰符对象。 该方法开始于至少第一和第二对象的节点表示的显示。 此后，从预定义的一组链接表示中选择表示底层链接对象的链接表示，以表示第一和第二对象之间的期望的关系条件。 集合的每个链接表示与不同的关系条件相关联。 每个关系条件可以进一步根据潜在的方程定义。 此后，显示所选择的链接表示在表示第一和第二对象的相应节点表示之间扩展。 因此，存在于第一和第二对象之间的关系条件的类型从在相关节点表示之间延伸的链接表示显而易见。

    Method of managing objects and parameter values associated with the objects within a simulation model
    10.
    发明授权
    Method of managing objects and parameter values associated with the objects within a simulation model 失效
    在仿真模型中管理与对象相关联的对象和参数值的方法

    公开(公告)号：US6078739A

    公开(公告)日：2000-06-20

    申请号：US978343

    申请日：1997-11-25

    申请人： Thomas S. Paterson ,  Alex L. Bangs

    发明人： Thomas S. Paterson ,  Alex L. Bangs

    IPC分类号： G06F19/00 ,  G06F9/44 ,  G06F17/50

    CPC分类号： G06F9/4428 ,  G06F9/4443 ,  G06Q10/04

    摘要： A method of managing objects within the simulation model commences with the storage of a first value for a particular parameter within an object of the simulation model. A panel is then displayed within the user interface. The relevant parameter of the above-identified object may then be identified for inclusion within this panel. In response to the identification of the parameter, an identifier (such as an icon) associated with the parameter is displayed within the panel. A second value for the relevant parameter of the object may then be inputted by a user via the panel. The second value for the parameter is then stored separately from the first value for the parameter, and these first and second values can be selectively applied to the parameter.

    摘要翻译： 在模拟模型中管理对象的方法开始于模拟模型的对象内的特定参数的第一值的存储。 然后在用户界面中显示面板。 然后可以识别上述对象的相关参数以包括在该面板内。 响应于该参数的识别，在面板内显示与参数相关联的标识符（例如图标）。 然后可以由用户经由面板输入对象的相关参数的第二值。 然后将参数的第二个值与参数的第一个值分开存储，并且这些第一个和第二个值可以选择性地应用于该参数。