公开(公告)号：US20110039791A1

公开(公告)日：2011-02-17

申请号：US12889564

申请日：2010-09-24

申请人： Hermona Soreq ,  Dan Grisaru ,  Varda Deutsch ,  Chava Perry ,  Marjorie Pick

发明人： Hermona Soreq ,  Dan Grisaru ,  Varda Deutsch ,  Chava Perry ,  Marjorie Pick

IPC分类号： A61K38/16 ,  C12N5/00 ,  A61P37/00 ,  A61P29/00 ,  A61P19/02

CPC分类号： A61K38/465 ,  C12Y301/01007

摘要： The present invention describes the use of an AChE-R-derived peptide, also known as ARP, as an inducer of hemopoietic cell differentiation and expansion, specifically for the granulocytic population. In addition, the use of ARP as an inducer of thrombopoietin and pro-inflammatory cytokines is also presented. ARP may further be used in the pre-transplant priming of hematopoietic stem cells. Other uses and methods utilizing ARP are also described herein.

摘要翻译： 本发明描述了AChE-R衍生肽（也称为ARP）作为造血细胞分化和扩增的诱导剂，特别是针对粒细胞群体的用途。 此外，还提出了使用ARP作为血小板生成素和促炎细胞因子的诱导剂。 在造血干细胞的移植前引发中还可以使用ARP。 本文还描述了利用ARP的其他用途和方法。

公开(公告)号：US20070065882A1

公开(公告)日：2007-03-22

申请号：US11401670

申请日：2006-04-11

申请人： Hermona Soreq ,  Amiram Eldor ,  Sofia Eldor ,  Varda Deutsch ,  Dan Grisaru

发明人： Hermona Soreq ,  Amiram Eldor ,  Sofia Eldor ,  Varda Deutsch ,  Dan Grisaru

IPC分类号： G01N33/567 ,  C07K16/40

CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K2319/00 ,  C12N9/18

摘要： The invention relates to a cell growth and/or differentiation regulatory peptide comprising a sequence of about 9 to about 150 amino acids derived from acetylcholinesterase amino acid sequence, preferably from the C-terminal region of acetylcholinesterase. The invention also relates to pharmaceutical compositions comprising the peptides, particularly for use in promoting survival of stem cells, promoting differentiation of stem cells, promoting growth of stem cells and/or promoting the growth-enhancing effect of a growth factor on stem cells, alone, or in combination with other growth factors. Of particular interest is the use of the peptides in the treatment of thrombocytopenia, post-irradiation conditions, post-chemotherapy conditions, or conditions following massive blood loss and promotion of neural progenitors in use for cell therapies aimed at restoring neural functions in diseased individuals. Further, the invention relates to antibodies against the peptides, inter alia for diagnostic use, for example, the diagnosis of stress-induced male infertility. The invention also relates to in vitro and in vivo methods for screening of drugs that affect the central nervous system, and are potential modulators of interactions between the “readthrough” form of acetylcholinesterase, AChE-R, the intracellular receptor RACK1 and the kinase PKC.

摘要翻译： 本发明涉及包含衍生自乙酰胆碱酯酶氨基酸序列的约9至约150个氨基酸序列的细胞生长和/或分化调节肽，优选来自乙酰胆碱酯酶的C-末端区。 本发明还涉及包含这些肽的药物组合物，特别是用于促进干细胞的存活，促进干细胞的分化，促进干细胞的生长和/或促进生长因子对干细胞的生长增强作用 ，或与其他生长因子结合使用。 特别感兴趣的是在治疗血小板减少症，照射后条件，化疗后条件或大量失血后的病症中使用肽，并促进神经祖细胞在用于恢复患病个体的神经功能的细胞疗法中。 此外，本发明涉及针对肽的抗体，特别是用于诊断用途，例如应激诱导的男性不育症的诊断。 本发明还涉及用于筛选影响中枢神经系统的药物的体外和体内方法，并且是“阅读”形式的乙酰胆碱酯酶，AChE-R，细胞内受体RACK1和激酶PKC之间的相互作用的潜在调节剂。

公开(公告)号：US20070224181A1

公开(公告)日：2007-09-27

申请号：US10589116

申请日：2005-02-10

申请人： Hermona Soreq ,  Dan Grisaru ,  Varda Deutsch ,  Chava Perry ,  Marjorie Pick

发明人： Hermona Soreq ,  Dan Grisaru ,  Varda Deutsch ,  Chava Perry ,  Marjorie Pick

IPC分类号： A61K38/46 ,  C12N5/02 ,  C12Q1/46

CPC分类号： A61K38/465 ,  C12Y301/01007

摘要： The present invention describes the use of an AChE-R-derived peptide, also known as ARP, as an inducer of hemopoietic cell differentiation and expansion, specifically for the granulocytic population. In addition, the use of ARP as an inducer of thrombopoietin and pro-inflammatory cytokines is also presented. ARP may further be used in the pre-transplant priming of hematopoietic stem cells. Other uses and methods utilizing ARP are also described herein.

摘要翻译： 本发明描述了AChE-R衍生肽（也称为ARP）作为造血细胞分化和扩增的诱导剂，特别是针对粒细胞群体的用途。 此外，还提出了使用ARP作为血小板生成素和促炎细胞因子的诱导剂。 在造血干细胞的移植前引发中还可以使用ARP。 本文还描述了利用ARP的其他用途和方法。

公开(公告)号：US07838493B2

公开(公告)日：2010-11-23

申请号：US10589116

申请日：2005-02-10

申请人： Hermona Soreq ,  Dan Grisaru ,  Varda Deutsch ,  Chava Perry ,  Marjorie Pick

发明人： Hermona Soreq ,  Dan Grisaru ,  Varda Deutsch ,  Chava Perry ,  Marjorie Pick

IPC分类号： A61K38/00

CPC分类号： A61K38/465 ,  C12Y301/01007

摘要： The present invention describes the use of an AChE-R-derived peptide, also known as ARP, as an inducer of hemopoietic cell differentiation and expansion, specifically for the granulocytic population. In addition, the use of ARP as an inducer of thrombopoietin and pro-inflammatory cytokines is also presented. ARP may further be used in the pre-transplant priming of hematopoietic stem cells. Other uses and methods utilizing ARP are also described herein.

摘要翻译： 本发明描述了AChE-R衍生肽（也称为ARP）作为造血细胞分化和扩增的诱导剂，特别是针对粒细胞群体的用途。 此外，还提出了使用ARP作为血小板生成素和促炎细胞因子的诱导剂。 在造血干细胞的移植前引发中还可以使用ARP。 本文还描述了利用ARP的其他用途和方法。

公开(公告)号：US07067486B2

公开(公告)日：2006-06-27

申请号：US09998042

申请日：2001-11-30

申请人： Hermona Soreq ,  Sofia Eldor, legal representative ,  Varda Deutch ,  Dan Grisaru

发明人： Amiram Eldor, deceased

IPC分类号： A61K38/00

CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K2319/00 ,  C12N9/18

摘要： The invention relates to a cell growth and/or differentiation regulatory peptide comprising a sequence of about 9 to about 150 amino acids derived from acetylcholinesterase amino acid sequence, preferably from the C-terminal region of acetylcholinesterase. The invention also relates to pharmaceutical compositions comprising the peptides, particularly for use in promoting survival of stem cells, promoting differentiation of stem cells, promoting growth of stem cells and/or promoting the growth-enhancing effect of a growth factor on stem cells, alone, or in combination with other growth factors. Of particular interest is the use of the peptides in the treatment of thrombocytopenia, post-irradiation conditions, post-chemotherapy conditions, or conditions following massive blood loss and promotion of neural progenitors in use for cell therapies aimed at restoring neural functions in diseased individuals. Further, the invention relates to antibodies against the peptides, inter alia for diagnostic use, for example, the diagnosis of stress-induced male infertility. The invention also relates to in vitro and in vivo methods for screening of drugs that affect the central nervous system, and are potential modulators of interactions between the “readthrough” form of acteylcholinesterase, AChE-R, the intracellular receptor RACK1 and the kinase PKC.