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    Implant having integrally-textured, hemocompatible, blood-contacting surfaces and method for producing the same
    1.
    发明授权
    Implant having integrally-textured, hemocompatible, blood-contacting surfaces and method for producing the same 失效
    具有整体纹理，血液相容性，接触血液的表面的植入物及其制备方法

    公开(公告)号：US5997796A

    公开(公告)日：1999-12-07

    申请号：US751839

    申请日：1996-11-18

    申请人： Daniel R. Moore

    发明人： Daniel R. Moore

    IPC分类号： A61F2/00 ,  A61L29/08 ,  A61L33/06 ,  B29C33/00 ,  B29C33/38 ,  B29C33/52 ,  B29C39/02 ,  B29C33/42

    CPC分类号： B29C39/026 ,  A61F2/0077 ,  A61L29/085 ,  A61L33/068 ,  B29C33/0027 ,  B29C33/3857 ,  B29C33/52 ,  Y10S264/44

    摘要： An implant having an integrally-textured, hemocompatible blood-contacting surface and a method for producing the same is provided. The implantable device can include a device body having a textured surface and a predefined complex shape, such as a bladder or a generally U-shaped conduit. The device body can be composed of a first device material, and the textured surface can be formed of a second device material on the obverse side of the device. The textured surface can have multiple, blood-compatible structures integrally formed thereon. The structures can be fibrils that are suitable for a generally uniform biological layer to be established thereupon. The method for producing an implantable device can include the steps of fabricating a mold; applying a flock to the mold; introducing a conformable dissoluble material to the mold; removing the dissoluble material from the mold; removing the flock from the dissoluble material using a first solvent thereby creating a dissoluble device form having a form surface having multiple invaginations therein; applying a layer of a selected device material to the dissoluble device form thereby providing a device wall with the structures being integrally formed thereon; and removing the dissoluble device form from the device wall by liquefying the device form, thereby providing the implantable device.

    摘要翻译： 提供具有整体纹理化血液接触表面的植入物及其制造方法。 可植入装置可以包括具有纹理表面和预定的复杂形状的装置主体，例如气囊或大致U形导管。 装置主体可以由第一装置材料构成，纹理化表面可以由装置的正面上的第二装置材料形成。 纹理表面可以具有多个与血液相容的结构，其整体形成在其上。 该结构可以是适合于在其上建立的通常均匀的生物层的原纤维。 用于生产可植入装置的方法可以包括制造模具的步骤; 将羊群应用于模具; 向模具中引入适形的可溶性材料; 从模具中除去可溶物; 使用第一溶剂从可溶性材料中除去绒毛，从而产生具有其中具有多个内陷的形状表面的溶解装置形式; 将所选择的装置材料层施加到可溶解装置形式，从而提供装置壁，所述结构一体形成在其上; 以及通过液化所述装置形式从所述装置壁移除所述可溶解装置形式，由此提供所述可植入装置。

    Devices, systems and methods for assisting blood flow
    2.
    发明授权
    Devices, systems and methods for assisting blood flow 失效
    用于辅助血液流动的装置，系统和方法

    公开(公告)号：US07588530B2

    公开(公告)日：2009-09-15

    申请号：US11184231

    申请日：2005-07-19

    申请人： Marlin Stephen Heilman ,  Douglas J. Koebler ,  Daniel R. Moore ,  Edward K. Prem

    发明人： Marlin Stephen Heilman ,  Douglas J. Koebler ,  Daniel R. Moore ,  Edward K. Prem

    IPC分类号： A61M1/10

    CPC分类号： A61M1/1046 ,  A61M1/1008 ,  A61M1/1037 ,  A61M1/1041 ,  A61M1/1049 ,  A61M1/1055 ,  A61M1/106 ,  A61M1/1086 ,  A61M1/1087 ,  A61M1/1098 ,  A61M1/12 ,  A61M1/122

    摘要： A pump includes a flexible conduit, at least one valve attached to the flexible conduit about the perimeter of the valve; and a drive mechanism to move the valve to pump blood within the conduit. The drive mechanism can, for example, be adapted to complete a single stroke during each heart ventricle contraction and/or to complete multiple strokes (that is, oscillate) during a single contraction. The moveable valve includes a plurality of openings. Each of the plurality of openings has a closure mechanism in operative connection therewith which is operable to at least partially close the opening to which it is operatively connected when the moveable valve is moved forward and to open the opening to which it is operatively connected when the valve is moved rearward. In one embodiment, each closure mechanism includes a flap of resilient material.

    摘要翻译： 泵包括柔性导管，至少一个阀，围绕阀的周边连接到柔性导管; 以及驱动机构，用于移动阀以泵送导管内的血液。 例如，驱动机构可以适于在每次心室收缩期间完成单个冲程和/或在单次收缩期间完成多个冲程（即，振荡）。 可移动阀包括多个开口。 多个开口中的每一个具有与其可操作地连接的闭合机构，其可操作以在可移动阀向前移动时至少部分地关闭其可操作地连接的开口，并且当可移动阀向前移动时打开其可操作地连接的开口 阀向后移动。 在一个实施例中，每个闭合机构包括弹性材料的翼片。