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公开(公告)号：US20110230557A1
公开(公告)日：2011-09-22
申请号：US13130900
申请日：2009-12-21
IPC分类号： A61K31/232 , C07C69/587 , A61K31/231 , A61P17/10 , A61P17/08 , C07C67/08 , A61K8/92 , A61Q19/00
CPC分类号： C07C69/587
摘要： The present invention relates to compounds of the following formula (I): where n is an integer between 1 and 15, m is 0, 1, 2 or 3, and R is the hydrocarbon chain of a polyunsaturated fatty acid selected from among omega 3 and omega 6, as well as to pharmaceutical or cosmetic compositions containing same, to a method for preparing and using same, in particular for treating acne and seborrhoeic dermatitis.
摘要翻译： 本发明涉及下式（I）的化合物：其中n为1至15之间的整数，m为0,1,2或3，R为选自ω3中的多不饱和脂肪酸的烃链 和ω6，以及含有其的药物或化妆品组合物，其制备和使用方法，特别是用于治疗痤疮和脂溢性皮炎。
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公开(公告)号：US08623916B2
公开(公告)日：2014-01-07
申请号：US13130900
申请日：2009-12-21
CPC分类号： C07C69/587
摘要： The present invention relates to compounds of the following formula (I): where n is an integer between 1 and 15, m is 0, 1, 2 or 3, and R is the hydrocarbon chain of a polyunsaturated fatty acid selected from among omega 3 and omega 6, as well as to pharmaceutical or cosmetic compositions containing same, to a method for preparing and using same, in particular for treating acne and seborrhoeic dermatitis.
摘要翻译： 本发明涉及下式（I）的化合物：其中n为1至15之间的整数，m为0,1,2或3，R为选自ω3中的多不饱和脂肪酸的烃链 和ω6，以及含有其的药物或化妆品组合物，其制备和使用方法，特别是用于治疗痤疮和脂溢性皮炎。
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公开(公告)号：US20120258065A1
公开(公告)日：2012-10-11
申请号：US13516347
申请日：2010-12-17
CPC分类号： A61Q19/008 , A61K8/375
摘要： The present invention relates to the use of 2,3-dihydroxypropyl dodecanoate for treating seborrhea.
摘要翻译： 本发明涉及2,3-二羟基丙基十二酸酯用于治疗脂溢性皮炎的用途。
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公开(公告)号：US07084172B2
公开(公告)日：2006-08-01
申请号：US10489736
申请日：2002-09-16
IPC分类号： A61K31/355 , C07D311/72
CPC分类号： C07D407/12 , C07D311/72
摘要： The invention concerns a bioprecursor of formula (I), wherein A1 and A2 represent independently of each other a radical derived from a molecule capable of being used in dermatology or in cosmetology; X and Y represent independently of each other a hydrogen atom, a hydroxy group or a C1–C20 alkyl group; and n represents an integer between 0 and 10
摘要翻译： 本发明涉及式（I）的生物前体，其中A 1和A 2个彼此独立地表示衍生自能够用于皮肤病学的分子或 美容; X和Y彼此独立地表示氢原子，羟基或C 1 -C 20烷基; n表示0〜10的整数
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5.发明授权Bioprecursors of a retinoic derivative and pharmaceutical and/or cosmetic compositions 失效视黄酸衍生物和药物和/或化妆品组合物的生物学前体公开(公告)号：US06818657B1
公开(公告)日：2004-11-16
申请号：US09937673
申请日：2001-09-28
IPC分类号： C08B1100
CPC分类号： C07H15/207 , A61K8/671 , A61Q19/02 , A61Q19/08 , Y10S514/859
摘要： The present invention relates to a ternary glucosyl complex which is a bioprecursor of at least one retinoic active ingredient for percutaneous application, having formula (I), wherein E represents a linear hydrocarbon spacer group that is branched or cyclized and has an aliphatic or aromatic content capable of containing one or several heteroatoms of oxygen and carrying one or several carbonyl groups; A represents a radical of a molecule of said retinoic active ingredient linked to the spacer group by a carboxylate function and n=1 or 2.
摘要翻译： 本发明涉及一种三元葡萄糖基复合物，其是用于经皮施用的至少一种视黄醇活性成分的生物前体，具有式（I），其中E表示支化或环化并具有脂族或芳族含量的直链烃间隔基 能够含有一个或多个氧原子并携带一个或几个羰基; A表示通过羧酸盐官能团连接到间隔基团的所述视黄酸活性成分的分子的基团，n = 1或2。
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6.发明授权Composition containing a precursor capable of being hydrolysed by glucocerebrosidase 有权含有能够被葡糖脑苷脂酶水解的前体的组合物公开(公告)号：US06569906B1
公开(公告)日：2003-05-27
申请号：US09856220
申请日：2001-05-18
IPC分类号： A61K31045
CPC分类号： C07H17/065 , A61K8/602 , A61K2800/70 , A61Q17/00 , A61Q19/00 , A61Q19/004 , A61Q19/007 , A61Q19/08 , C07H15/203
摘要： The invention concerns a composition capable of being hydrolyzed by a cutaneous enzyme, glucocerebrosidase. The active precursor is advantageously a gluco-conjugate derived from phenol whereof the two &agr; carbons are free. The invention also concerns the use of such compositions against light-induced skin ageing or for making a medicine for treating certain skin diseases. The invention further concerns novel glucosylated compounds.
摘要翻译： 本发明涉及能够被皮肤酶，葡糖脑苷脂酶水解的组合物。 活性前体有利地是衍生自苯酚的葡糖共轭体，其中两个α碳是自由基。 本发明还涉及这种组合物对光诱导的皮肤老化或用于制备用于治疗某些皮肤疾病的药物的用途。 本发明还涉及新的葡糖基化化合物。
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