公开(公告)号：US08604852B1

公开(公告)日：2013-12-10

申请号：US13610469

申请日：2012-09-11

Applicant: Sebastian Turullols ,  Changku Hwang ,  Daniel Woo ,  Yifan YangGong

Inventor： Sebastian Turullols ,  Changku Hwang ,  Daniel Woo ,  Yifan YangGong

IPC: H03L7/06

CPC classification number: H03L7/099 ,  H03L7/07 ,  H03L7/23

Abstract: In an integrated circuit that provides a clock signal, an asymmetric frequency-locked loop (AFLL) includes a first digitally controlled oscillator (DCO) that outputs a first signal having a first fundamental frequency, and a second DCO that outputs a second signal having a second fundamental frequency that is less than the first fundamental frequency. Moreover, the AFLL includes control logic that selects one of the first DCO and the second DCO based on an instantaneous value of a power-supply voltage and an average power-supply voltage so that an impact of power-supply voltage variations on a time-critical path in the integrated circuit is reduced. For example, the control logic may select the first DCO if the instantaneous value of the power-supply voltage is greater than the average power-supply voltage; otherwise, the control logic may select the second DCO.

Abstract translation: 在提供时钟信号的集成电路中，非对称频率锁相环（AFLL）包括输出具有第一基频的第一信号的第一数字控制振荡器（DCO）和输出具有第一基频的第二信号的第二DCO， 第二基频小于第一基频。 此外，AFLL包括基于电源电压和平均电源电压的瞬时值来选择第一DCO和第二DCO中的一个的控制逻辑，使得电源电压的变化对时间 - 集成电路中的关键路径减少。 例如，如果电源电压的瞬时值大于平均电源电压，则控制逻辑可以选择第一DCO; 否则，控制逻辑可以选择第二DCO。

公开(公告)号：US06789424B2

公开(公告)日：2004-09-14

申请号：US10366900

申请日：2003-02-14

Applicant: Sverre Knudsen ,  Arne Berg ,  James R. Dunphy ,  Daniel Woo

Inventor： Sverre Knudsen ,  Arne Berg ,  James R. Dunphy ,  Daniel Woo

IPC: G01P1508

CPC classification number: G01V1/181 ,  G01P15/093 ,  G01V1/226

Abstract: A highly sensitive accelerometer for determining the acceleration of a structure includes a mass within a housing suspended by opposing support members. The support members are alternately wound around a pair of fixed mandrels and the mass in a push pull arrangement. At least a portion of one of the support members comprises a transducer capable measuring the displacement of the mass within the housing. An embodiment of the invention employs optical fiber coils as the support members for use in interferometric sensing processes. Arrays of such interferometer based accelerometers may be multiplexed using known techniques.

Abstract translation: 用于确定结构的加速度的高度敏感的加速度计包括由相对的支撑构件悬挂的壳体内的质量。 支撑构件交替地卷绕在一对固定的心轴和质量块的推拉装置中。 支撑构件中的一个的至少一部分包括能够测量壳体内的质量的位移的换能器。 本发明的实施例采用光纤线圈作为用于干涉测量过程的支撑构件。 可以使用已知技术来复用这种基于干涉仪的加速度计的阵列。

公开(公告)号：US07135305B2

公开(公告)日：2006-11-14

申请号：US10398882

申请日：2001-10-12

Applicant: Joseph P. Broderick ,  Joseph F. Clark ,  Daniel Woo

Inventor： Joseph P. Broderick ,  Joseph F. Clark ,  Daniel Woo

IPC: C12Q1/56

CPC classification number: G01N33/86 ,  A61K38/1709 ,  A61K38/49 ,  A61K45/06 ,  A61K2300/00

Abstract: Methods for inhibiting lysis of coagulated blood and reducing risk of excessive lysis comprising administration of lysis-inhibiting amounts of apolipoprotein E4, and methods for inhibiting lysis of coagulated blood and reducing risk of excessive lysis comprising administration of a specific level of a lysis-inhibiting agent wherein the specific level is based on the apolipoprotein phenotype of an individual, are provided. Methods for enhancing lysis of coagulated blood by administration of an Apo E peptide fragment to blood containing a clot lysis agent are also provided.

Abstract translation: 抑制凝血血液溶解和降低过度裂解风险的方法，包括施用溶解抑制量的载脂蛋白E4，以及抑制凝血血液溶解和降低过度裂解风险的方法，包括施用特定水平的裂解抑制剂 其中特异性水平基于个体的载脂蛋白表型。 还提供了通过将Apo E肽片段施用于含有凝血裂解剂的血液来增强凝血血液溶解的方法。

公开(公告)号：US07013729B2

公开(公告)日：2006-03-21

申请号：US10933132

申请日：2004-09-02

Applicant: Sverre Knudsen ,  Arne Berg ,  James R. Dunphy ,  Daniel Woo

Inventor： Sverre Knudsen ,  Arne Berg ,  James R. Dunphy ,  Daniel Woo

IPC: G01P15/08

CPC classification number: G01V1/181 ,  G01P15/093 ,  G01V1/226

Abstract: A highly sensitive accelerometer for determining the acceleration of a structure includes a mass within a housing suspended by opposing support members. The support members are alternately wound around a pair of fixed mandrels and the mass in a push pull arrangement. At least a portion of one of the support members comprises a transducer capable measuring the displacement of the mass within the housing. An embodiment of the invention employs optical fiber coils as the support members for use in interferometric sensing processes. Arrays of such interferometer based accelerometers may be multiplexed using known techniques.

公开(公告)号：US20050195687A1

公开(公告)日：2005-09-08

申请号：US11109387

申请日：2005-04-19

Applicant: Daniel Woo

Inventor： Daniel Woo

IPC: H04R1/44 ,  H04R1/00

CPC classification number: H04R1/44

Abstract: A pressure compensated hydrophone for measuring dynamic pressures is disclosed. The hydrophone includes a compliant hollow mandrel with a single optical fiber coiled around at least a portion of the mandrel. The mandrel further includes at least one pressure relief valve for compensating for changes in hydrostatic pressure. The pressure relief valve includes a micro-hole, which allows hydrostatic pressures or low frequency pressure events to couple into the interior of the mandrel to provide compensation against such pressure. Higher frequencies pressure events of interest do not couple through the micro-hole and therefore only act only on the exterior of the mandrel, allowing for their detection. Because (quasi) hydrostatic events are compensated for, the mandrel may be made particularly compliant, rendering the singular fiber optic coil particularly sensitive to the detection of the higher frequency signals of interest.

Abstract translation: 公开了一种用于测量动态压力的压力补偿水听器。 水听器包括柔性中空心轴，其具有围绕心轴的至少一部分卷绕的单个光纤。 心轴还包括至少一个用于补偿静水压力变化的泄压阀。 减压阀包括微孔，其允许静水压力或低频压力事件耦合到心轴的内部以提供抵抗这种压力的补偿。 感兴趣的较高频率的压力事件不会通过微孔耦合，因此只能作用在心轴的外部，从而允许它们的检测。 由于（准）流体静力学事件被补偿，心轴可以被制成特别顺从，使单个光纤线圈对感兴趣的较高频率信号的检测特别敏感。

公开(公告)号：US20050076713A1

公开(公告)日：2005-04-14

申请号：US10933132

申请日：2004-09-02

Applicant: Sverre Knudsen ,  Arne Berg ,  James Dunphy ,  Daniel Woo

Inventor： Sverre Knudsen ,  Arne Berg ,  James Dunphy ,  Daniel Woo

IPC: G01P15/03 ,  G01P15/09 ,  G01P15/093 ,  G01P15/12 ,  G01V1/18 ,  E21B49/00 ,  E21B47/12

CPC classification number: G01V1/181 ,  G01P15/093 ,  G01V1/226

Abstract: A highly sensitive accelerometer for determining the acceleration of a structure includes a mass within a housing suspended by opposing support members. The support members are alternately wound around a pair of fixed mandrels and the mass in a push pull arrangement. At least a portion of one of the support members comprises a transducer capable measuring the displacement of the mass within the housing. An embodiment of the invention employs optical fiber coils as the support members for use in interferometric sensing processes. Arrays of such interferometer based accelerometers may be multiplexed using known techniques.

Abstract translation: 用于确定结构的加速度的高度敏感的加速度计包括由相对的支撑构件悬挂的壳体内的质量。 支撑构件交替地卷绕在一对固定的心轴和质量块的推拉装置中。 支撑构件中的一个的至少一部分包括能够测量壳体内的质量的位移的换能器。 本发明的实施例采用光纤线圈作为用于干涉测量过程的支撑构件。 可以使用已知技术来复用这种基于干涉仪的加速度计的阵列。

公开(公告)号：US20050201663A1

公开(公告)日：2005-09-15

申请号：US10796594

申请日：2004-03-09

Applicant: Daniel Woo

Inventor： Daniel Woo

IPC: G01B9/02 ,  G01D5/26 ,  G01H9/00 ,  G01L1/24 ,  G01V1/18 ,  G02B6/00 ,  G02B6/34 ,  H04R1/44 ,  H04R23/00

CPC classification number: H04R1/44 ,  G01D5/35316 ,  G01V1/186 ,  G02B6/29356

Abstract: A method and apparatus for reducing the difficulty of controlling the length of a section of optical waveguide wrapped around a mandrel separating Bragg gratings forming an interferometric sensor are provided. The section of optical waveguide may be wrapped on a mandrel having at least two different outer diameters. The mandrel may also include one or more bores for receiving and protecting the Bragg gratings.

Abstract translation: 提供了一种降低控制缠绕在形成干涉测量传感器的分离布拉格光栅的心轴上的光波导部分的长度的控制的方法和装置。 光波导的部分可以缠绕在具有至少两个不同外径的心轴上。 心轴还可以包括用于接收和保护布拉格光栅的一个或多个孔。

公开(公告)号：US06575033B1

公开(公告)日：2003-06-10

申请号：US09410634

申请日：1999-10-01

Applicant: Sverre Knudsen ,  Arne Berg ,  James R. Dunphy ,  Daniel Woo

Inventor： Sverre Knudsen ,  Arne Berg ,  James R. Dunphy ,  Daniel Woo

IPC: G01P1508

CPC classification number: G01V1/181 ,  G01P15/093 ,  G01V1/226

Abstract: A highly sensitive accelerometer for determining the acceleration of a structure includes a mass within a housing suspended by opposing support members. The support members are alternately wound around a pair of fixed mandrels and the mass in a push pull arrangement. At least a portion of one of the support members comprises a transducer capable measuring the displacement of the mass within the housing. An embodiment of the invention employs optical fiber coils as the support members for use in interferometric sensing processes. Arrays of such interferometer based accelerometers may be multiplexed using known techniques.

Abstract translation: 用于确定结构的加速度的高度敏感的加速度计包括由相对的支撑构件悬挂的壳体内的质量。 支撑构件交替地卷绕在一对固定的心轴和质量块的推拉装置中。 支撑构件中的一个的至少一部分包括能够测量壳体内的质量的位移的换能器。 本发明的实施例采用光纤线圈作为用于干涉测量过程的支撑构件。 可以使用已知技术来复用这种基于干涉仪的加速度计的阵列。

公开(公告)号：US07208288B2

公开(公告)日：2007-04-24

申请号：US10398880

申请日：2001-10-12

Applicant: Joseph P. Broderick ,  Joseph F. Clark ,  Daniel Woo

Inventor： Joseph P. Broderick ,  Joseph F. Clark ,  Daniel Woo

IPC: C12Q1/56

CPC classification number: A61K38/166 ,  A61K38/1709 ,  A61K38/49 ,  Y10S514/822 ,  A61K2300/00

Abstract: Methods for enhancing the lysis of coagulated blood comprise administering to coagulated blood a combination of clot clysis agent and a lysis enhancing amount of apolipoprotein E2 (Apo E2) or a therapeutic derivative thereof. Methods for reducing the risk of blood coagulation comprise administering to blood a combination of a clot lysis agent and a lysis enhancing amount of Apo E2 or a therapeutic derivative thereof. Additional methods for enhancing the lysis of coagulated blood comprise administering to an individual a specific level of clot lysis agent wherein the specific level is based upon the apolipoprotein phenotype of the individual. Further methods for reducing the risks of blood coagulation comprise administering to blood a specific level of a clot lysis agent wherein the specific level is based upon the apolipoprotein phenotype of the individual.

Abstract translation: 用于增强凝血血液溶解的方法包括向凝血血液施用凝块溶解剂和溶解促进量的载脂蛋白E2（Apo E2）或其治疗衍生物的组合。 降低凝血风险的方法包括向血液施用凝块裂解剂和裂解增强量的Apo E2或其治疗衍生物的组合。 增强凝血血液溶解的其它方法包括向个体施用特定水平的凝块溶解剂，其中特异性水平基于个体的载脂蛋白表型。 用于降低凝血风险的其它方法包括向血液施用特定水平的凝块溶解剂，其中特异性水平基于个体的载脂蛋白表型。