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公开(公告)号：US20080119559A1
公开(公告)日：2008-05-22
申请号：US11925283
申请日：2007-10-26
IPC分类号： A61K31/192 , A61P35/00
CPC分类号： A61K31/192 , A61K31/4439 , A61K45/06 , A61K2300/00
摘要： The NSAID, sulindac and/or its metabolites and derivatives, in combination with hydrogen peroxide or another oxidizing agent, such as arsenic trioxide that generates reactive oxygen species (ROS), significantly enhances the killing of cancer cells. This effect occurs at concentrations of each compound that individually have little or no activity directed against cancer cells. A skin cream has been developed and used to treat skin cancer and precancerous skin growths that effectively removes the lesions with no effect on surrounding normal skin.
摘要翻译： NSAID，舒林酸和/或其代谢产物和衍生物与过氧化氢或其他氧化剂（例如产生活性氧（ROS））的三氧化二砷组合，显着增强了癌细胞的杀伤作用。 这种效应发生在各自对于癌细胞单独具有很少或没有活性的化合物的浓度。 已经开发了一种护肤霜，用于治疗皮肤癌和癌前皮肤生长，其有效地去除病变，对周围的正常皮肤没有影响。
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公开(公告)号：US08603985B2
公开(公告)日：2013-12-10
申请号：US12759952
申请日：2010-04-14
IPC分类号： A61P35/00
CPC分类号： A61K31/192 , A61K9/0014 , A61K9/06 , A61K31/4439 , A61K33/40 , A61K45/06 , A61K2300/00
摘要： The NSAID, sulindac and/or its metabolites and derivatives, in combination with hydrogen peroxide or another oxidizing agent, such as arsenic trioxide that generates reactive oxygen species (ROS), significantly enhances the killing of cancer cells. This effect occurs at concentrations of each compound that individually have little or no activity directed against cancer cells. A skin cream has been developed and used to treat skin cancer and precancerous skin growths that effectively removes the lesions with no effect on surrounding normal skin.
摘要翻译： NSAID，舒林酸和/或其代谢产物和衍生物与过氧化氢或其他氧化剂（例如产生活性氧（ROS））的三氧化二砷组合，显着增强了癌细胞的杀伤作用。 这种效应发生在各自对于癌细胞单独具有很少或没有活性的化合物的浓度。 已经开发了一种护肤霜，用于治疗皮肤癌和癌前皮肤生长，其有效地去除病变，对周围的正常皮肤没有影响。
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公开(公告)号：US08765808B2
公开(公告)日：2014-07-01
申请号：US11925283
申请日：2007-10-26
IPC分类号： A61K31/255 , A61K33/40
CPC分类号： A61K31/192 , A61K31/4439 , A61K45/06 , A61K2300/00
摘要： The NSAID, sulindac and/or its metabolites and derivatives, in combination with hydrogen peroxide or another oxidizing agent, such as arsenic trioxide that generates reactive oxygen species (ROS), significantly enhances the killing of cancer cells. This effect occurs at concentrations of each compound that individually have little or no activity directed against cancer cells. A skin cream has been developed and used to treat skin cancer and precancerous skin growths that effectively removes the lesions with no effect on surrounding normal skin.
摘要翻译： NSAID，舒林酸和/或其代谢产物和衍生物与过氧化氢或其他氧化剂（例如产生活性氧（ROS））的三氧化二砷组合，显着增强了癌细胞的杀伤作用。 这种效应发生在各自对于癌细胞单独具有很少或没有活性的化合物的浓度。 已经开发了一种护肤霜，用于治疗皮肤癌和癌前皮肤生长，其有效地去除病变，对周围的正常皮肤没有影响。
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公开(公告)号：US20100260864A1
公开(公告)日：2010-10-14
申请号：US12759952
申请日：2010-04-14
IPC分类号： A61K33/40 , A61K31/192 , A61K31/195 , A61K33/36 , A61P35/00
CPC分类号： A61K31/192 , A61K9/0014 , A61K9/06 , A61K31/4439 , A61K33/40 , A61K45/06 , A61K2300/00
摘要： The NSAID, sulindac and/or its metabolites and derivatives, in combination with hydrogen peroxide or another oxidizing agent, such as arsenic trioxide that generates reactive oxygen species (ROS), significantly enhances the killing of cancer cells. This effect occurs at concentrations of each compound that individually have little or no activity directed against cancer cells. A skin cream has been developed and used to treat skin cancer and precancerous skin growths that effectively removes the lesions with no effect on surrounding normal skin.
摘要翻译： NSAID，舒林酸和/或其代谢产物和衍生物与过氧化氢或其他氧化剂（例如产生活性氧（ROS））的三氧化二砷组合，显着增强了癌细胞的杀伤作用。 这种效应发生在各自对于癌细胞单独具有很少或没有活性的化合物的浓度。 已经开发了一种护肤霜，用于治疗皮肤癌和癌前皮肤生长，其有效地去除病变，对周围的正常皮肤没有影响。
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公开(公告)号：US20060235080A1
公开(公告)日：2006-10-19
申请号：US11388248
申请日：2006-03-23
IPC分类号： A61K31/192
CPC分类号： A61K31/192 , A61K9/0014 , A61K9/06 , A61K31/4439 , A61K33/40 , A61K45/06 , A61K2300/00
摘要： The NSAID, sulindac and/or its metabolites and derivatives, in combination with hydrogen peroxide or another oxidizing agent, such as arsenic trioxide that generates reactive oxygen species (ROS), significantly enhances the killing of cancer cells. This effect occurs at concentrations of each compound that individually have little or no activity directed against cancer cells. A skin cream has been developed and used to treat skin cancer and precancerous skin growths that effectively removes the lesions with no effect on surrounding normal skin.
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公开(公告)号：US08357720B2
公开(公告)日：2013-01-22
申请号：US12557022
申请日：2009-09-10
IPC分类号： A61K31/255 , A61K33/40
CPC分类号： A61K31/192 , A61K31/352 , A61K31/69
摘要： The NSAID, sulindac and/or its metabolites and derivatives, in combination with an agent that generates or induces reactive oxygen species (ROS), significantly enhances the killing of abnormal cells but does not affect normal cells. This effect occurs at concentrations of each compound that individually have little or no activity directed against the abnormal cells.
摘要翻译： NSAID，舒林酸和/或其代谢物和衍生物与产生或诱导活性氧（ROS）的药剂组合显着增强异常细胞的杀伤，但不影响正常细胞。 这种效应发生在各自对于异常细胞具有很少或没有活性的化合物的浓度。
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公开(公告)号：US08258181B2
公开(公告)日：2012-09-04
申请号：US11388248
申请日：2006-03-23
IPC分类号： A61K31/255 , A61K33/40
CPC分类号： A61K31/192 , A61K9/0014 , A61K9/06 , A61K31/4439 , A61K33/40 , A61K45/06 , A61K2300/00
摘要： The NSAID, sulindac and/or its metabolites and derivatives, in combination with hydrogen peroxide or another oxidizing agent, such as arsenic trioxide that generates reactive oxygen species (ROS), significantly enhances the killing of cancer cells. This effect occurs at concentrations of each compound that individually have little or no activity directed against cancer cells. A skin cream has been developed and used to treat skin cancer and precancerous skin growths that effectively removes the lesions with no effect on surrounding normal skin.
摘要翻译： NSAID，舒林酸和/或其代谢产物和衍生物与过氧化氢或其他氧化剂（例如产生活性氧（ROS））的三氧化二砷组合，显着增强了癌细胞的杀伤作用。 这种效应发生在各自对于癌细胞单独具有很少或没有活性的化合物的浓度。 已经开发了一种护肤霜，用于治疗皮肤癌和癌前皮肤生长，其有效地去除病变，对周围的正常皮肤没有影响。
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公开(公告)号：US20100069331A1
公开(公告)日：2010-03-18
申请号：US12557022
申请日：2009-09-10
IPC分类号： A61K31/192 , A61P35/00 , A61K31/352 , A61K31/69 , C12N5/00
CPC分类号： A61K31/192 , A61K31/352 , A61K31/69
摘要： The NSAID, sulindac and/or its metabolites and derivatives, in combination with an agent that generates or induces reactive oxygen species (ROS), significantly enhances the killing of abnormal cells but does not affect normal cells. This effect occurs at concentrations of each compound that individually have little or no activity directed against the abnormal cells.
摘要翻译： NSAID，舒林酸和/或其代谢物和衍生物与产生或诱导活性氧（ROS）的药剂组合显着增强异常细胞的杀伤，但不影响正常细胞。 这种效应发生在各自对于异常细胞具有很少或没有活性的化合物的浓度。
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