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公开(公告)号：US20080119559A1
公开(公告)日：2008-05-22
申请号：US11925283
申请日：2007-10-26
IPC分类号： A61K31/192 , A61P35/00
CPC分类号： A61K31/192 , A61K31/4439 , A61K45/06 , A61K2300/00
摘要： The NSAID, sulindac and/or its metabolites and derivatives, in combination with hydrogen peroxide or another oxidizing agent, such as arsenic trioxide that generates reactive oxygen species (ROS), significantly enhances the killing of cancer cells. This effect occurs at concentrations of each compound that individually have little or no activity directed against cancer cells. A skin cream has been developed and used to treat skin cancer and precancerous skin growths that effectively removes the lesions with no effect on surrounding normal skin.
摘要翻译： NSAID，舒林酸和/或其代谢产物和衍生物与过氧化氢或其他氧化剂（例如产生活性氧（ROS））的三氧化二砷组合，显着增强了癌细胞的杀伤作用。 这种效应发生在各自对于癌细胞单独具有很少或没有活性的化合物的浓度。 已经开发了一种护肤霜，用于治疗皮肤癌和癌前皮肤生长，其有效地去除病变，对周围的正常皮肤没有影响。
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2.发明授权Method of detecting ribosomal protein antibodies in systemic lupus erythematosus 失效检测系统性红斑狼疮中核糖体蛋白抗体的方法
公开(公告)号：US4865970A
公开(公告)日：1989-09-12
申请号：US834717
申请日：1986-02-28
申请人： Nathan Brot , Keith Elkon , Susan M. Skelly , Herbert Weissbach
发明人： Nathan Brot , Keith Elkon , Susan M. Skelly , Herbert Weissbach
IPC分类号： C07K14/47 , C07K17/08 , G01N33/564
CPC分类号： C07K14/4713 , C07K17/08 , G01N33/564 , G01N2800/104 , Y10S436/811 , Y10S530/806
摘要： This invention provides methods for the diagnosis of systemic lupus erythematosus in patients, the sera of which contain antibodies reactive against ribosomal proteins P0, P1 and P2. A peptide containing an amino acid sequence corresponding to the carboxyl termini of the ribosomal proteins, which peptide is bound to a solid carrier, is also provided for use in such methods.
摘要翻译： 本发明提供了用于诊断患者系统性红斑狼疮的方法，其血清含有对核糖体蛋白质P0，P1和P2具有反应性的抗体。 还提供了含有对应于核糖体蛋白的羧基末端的氨基酸序列的肽，该肽与固体载体结合，用于此类方法。
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公开(公告)号：US08487128B2
公开(公告)日：2013-07-16
申请号：US12115331
申请日：2008-05-05
申请人： Herbert Weissbach , Nathan Brot
发明人： Herbert Weissbach , Nathan Brot
IPC分类号： C07C315/00
CPC分类号： A61K31/192 , Y02A50/411 , Y02A50/475
摘要： The invention provides compositions comprising sulindac, R-epimer sulindac, S-epimer sulindac, derivatives, metabolites, and structural analogs thereof which protect normal cells against damage caused by solar rays, oxidative damage, environmental factors, diseases and organisms.
摘要翻译： 本发明提供包含舒林酸，R-差向异构体舒林酸，S-差向异构体舒林酸，其衍生物，代谢物及其结构类似物的组合物，其保护正常细胞免受由太阳光线，氧化损伤，环境因素，疾病和生物引起的损害。
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公开(公告)号：US08357720B2
公开(公告)日：2013-01-22
申请号：US12557022
申请日：2009-09-10
IPC分类号： A61K31/255 , A61K33/40
CPC分类号： A61K31/192 , A61K31/352 , A61K31/69
摘要： The NSAID, sulindac and/or its metabolites and derivatives, in combination with an agent that generates or induces reactive oxygen species (ROS), significantly enhances the killing of abnormal cells but does not affect normal cells. This effect occurs at concentrations of each compound that individually have little or no activity directed against the abnormal cells.
摘要翻译： NSAID，舒林酸和/或其代谢物和衍生物与产生或诱导活性氧（ROS）的药剂组合显着增强异常细胞的杀伤，但不影响正常细胞。 这种效应发生在各自对于异常细胞具有很少或没有活性的化合物的浓度。
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公开(公告)号：US20090069428A1
公开(公告)日：2009-03-12
申请号：US12185480
申请日：2008-08-04
申请人： Herbert Weissbach , Nathan Brot
发明人： Herbert Weissbach , Nathan Brot
IPC分类号： A61K31/195 , C07C317/06 , A61P25/00
CPC分类号： C07D209/26 , A61K38/00 , C07C317/44 , C07C317/50 , C07C323/59 , C07C323/60 , C07C2602/08 , C07D307/58 , C07K5/06026 , C07K5/06078
摘要： The invention provides small molecules that act as catalytic antioxidants and methods of use thereof. The compounds can repeatedly bind and destroy reactive oxygen species by serving as substrates for enzymes of the methionine sulfoxide reductase (Msr) class. Some embodiments of the catalytic antioxidant compounds are derived from drugs with anti-inflammatory activity due to inhibition of cyclooxygenase enzymes.
摘要翻译： 本发明提供用作催化抗氧化剂的小分子及其使用方法。 化合物可以通过作为蛋氨酸亚砜还原酶（Msr）类的酶的底物反复结合和破坏活性氧。 催化抗氧化剂化合物的一些实施方案来自具有抗环氧合酶的抑制作用的具有抗炎活性的药物。
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公开(公告)号：US20070072935A1
公开(公告)日：2007-03-29
申请号：US11512616
申请日：2006-08-29
申请人： Herbert Weissbach , Nathan Brot
发明人： Herbert Weissbach , Nathan Brot
IPC分类号： A61K31/405 , A61K31/198 , C07D209/18 , C07C317/50
CPC分类号： C07D209/26 , A61K38/00 , C07C317/44 , C07C317/50 , C07C323/59 , C07C323/60 , C07C2602/08 , C07D307/58 , C07K5/06026 , C07K5/06078
摘要： The invention provides small molecules that act as catalytic antioxidants and methods of use thereof. The compounds can repeatedly bind and destroy reactive oxygen species by serving as substates for enzymes of the methionine sulfoxide reductase (Msr) class. Some embodiments of the catalytic antioxidant compounds are derived from drugs with anti-inflammatory activity due to inhibition of cyclooxygenase enzymes.
摘要翻译： 本发明提供用作催化抗氧化剂的小分子及其使用方法。 通过作为甲硫氨酸亚砜还原酶（Msr）类的酶的副产物，化合物可以反复结合和破坏活性氧。 催化抗氧化剂化合物的一些实施方案来自具有抗环氧合酶的抑制作用的具有抗炎活性的药物。
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公开(公告)号：US08258181B2
公开(公告)日：2012-09-04
申请号：US11388248
申请日：2006-03-23
IPC分类号： A61K31/255 , A61K33/40
CPC分类号： A61K31/192 , A61K9/0014 , A61K9/06 , A61K31/4439 , A61K33/40 , A61K45/06 , A61K2300/00
摘要： The NSAID, sulindac and/or its metabolites and derivatives, in combination with hydrogen peroxide or another oxidizing agent, such as arsenic trioxide that generates reactive oxygen species (ROS), significantly enhances the killing of cancer cells. This effect occurs at concentrations of each compound that individually have little or no activity directed against cancer cells. A skin cream has been developed and used to treat skin cancer and precancerous skin growths that effectively removes the lesions with no effect on surrounding normal skin.
摘要翻译： NSAID，舒林酸和/或其代谢产物和衍生物与过氧化氢或其他氧化剂（例如产生活性氧（ROS））的三氧化二砷组合，显着增强了癌细胞的杀伤作用。 这种效应发生在各自对于癌细胞单独具有很少或没有活性的化合物的浓度。 已经开发了一种护肤霜，用于治疗皮肤癌和癌前皮肤生长，其有效地去除病变，对周围的正常皮肤没有影响。
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公开(公告)号：US20100069331A1
公开(公告)日：2010-03-18
申请号：US12557022
申请日：2009-09-10
IPC分类号： A61K31/192 , A61P35/00 , A61K31/352 , A61K31/69 , C12N5/00
CPC分类号： A61K31/192 , A61K31/352 , A61K31/69
摘要： The NSAID, sulindac and/or its metabolites and derivatives, in combination with an agent that generates or induces reactive oxygen species (ROS), significantly enhances the killing of abnormal cells but does not affect normal cells. This effect occurs at concentrations of each compound that individually have little or no activity directed against the abnormal cells.
摘要翻译： NSAID，舒林酸和/或其代谢物和衍生物与产生或诱导活性氧（ROS）的药剂组合显着增强异常细胞的杀伤，但不影响正常细胞。 这种效应发生在各自对于异常细胞具有很少或没有活性的化合物的浓度。
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公开(公告)号：US20090326073A1
公开(公告)日：2009-12-31
申请号：US12115331
申请日：2008-05-05
申请人： Herbert Weissbach , Nathan Brot
发明人： Herbert Weissbach , Nathan Brot
CPC分类号： A61K31/192 , Y02A50/411 , Y02A50/475
摘要： The invention provides compositions comprising sulindac, R-epimer sulindac, S-epimer sulindac, derivatives, metabolites, and structural analogs thereof which protect normal cells against damage caused by solar rays, oxidative damage, environmental factors, diseases and organisms.
摘要翻译： 本发明提供包含舒林酸，R-差向异构体舒林酸，S-差向异构体舒林酸，其衍生物，代谢物及其结构类似物的组合物，其保护正常细胞免受由太阳光线，氧化损伤，环境因素，疾病和生物引起的损害。
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公开(公告)号：US20090312238A1
公开(公告)日：2009-12-17
申请号：US12299109
申请日：2007-05-03
申请人： Daphna Sagher , David Brunell , Herbert Weissbach
发明人： Daphna Sagher , David Brunell , Herbert Weissbach
CPC分类号： A61K38/1709 , A61K31/315 , A61K33/04 , A61K45/06
摘要： The present invention relates to the use of MT as a reducing system for the Msr enzymes and other oxioreductase enzymes which form similar intermediates. Specifically, the invention provides for a reduction in the level of oxidative damage in cells through an increase in levels of MT by administration of suitable compounds, resulting in an increase in the activity of the Msr enzymes.
摘要翻译： 本发明涉及MT作为形成类似中间体的Msr酶和其它氧还原酶的还原体系的用途。 具体地，本发明通过施用合适的化合物通过增加MT的水平来降低细胞中的氧化损伤水平，导致Msr酶的活性增加。
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