公开(公告)号：US08609400B2

公开(公告)日：2013-12-17

申请号：US12662930

申请日：2010-05-12

申请人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G. M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Douglas Schein

发明人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G. M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Douglas Schein

IPC分类号： A01N1/02

CPC分类号： G06F17/30876 ,  A01N1/02 ,  A01N1/0247 ,  A01N1/0273 ,  H04L67/02

摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

摘要翻译： 器官灌注装置和方法监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。 其他装置包括器官输送器，器官盒和器官诊断装置。 该方法包括在低温和/或正常体温温度下灌注器官，优选在用于器官运输和/或储存的低温器官冲洗之后。 该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。 可以自动监测器官的活力，优选通过监测医用流体灌注液的特性。 可以使用控制程序自动控制灌注过程。

公开(公告)号：US08420381B2

公开(公告)日：2013-04-16

申请号：US12926277

申请日：2010-11-05

申请人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G. M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Dennis J. Steibel ,  Richard Fraser ,  Stanley Harris ,  Douglas Schein

发明人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G. M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Dennis J. Steibel ,  Richard Fraser ,  Stanley Harris ,  Douglas Schein

IPC分类号： A01N1/02 ,  C12M1/36

CPC分类号： G06F17/30876 ,  A01N1/02 ,  A01N1/0247 ,  A01N1/0273 ,  H04L67/02

摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

摘要翻译： 器官灌注装置和方法监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。 其他装置包括器官输送器，器官盒和器官诊断装置。 该方法包括在低温和/或正常体温温度下灌注器官，优选在用于器官运输和/或储存的低温器官冲洗之后。 该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。 通过用正常体温温度下的医用流体例如氧合交联血红蛋白的碳酸氢盐医疗液灌注器官，恢复高能量核苷酸（例如ATP）水平来恢复器官存活力。 在灌注中，器官灌注压力优选地响应于设置在置于器官中的管的末端中的传感器，通过气动加压的医用液体储存器进行控制，提供灌注压力微调，超压预防和紧急流量截止。 在低体温模式中，器官用液体灌注，优选地是含有抗氧化剂的简单晶体溶液，间歇地或以缓慢的连续流动。 可以从具有低压头的中间容器将药液输送到器官中，以避免器官过压。 防止过度加压防止或减少对血管内皮衬里和器官组织的损害。 可以自动监测器官的活力，优选通过监测医用流体灌注液的特性。 可以使用控制程序自动控制灌注过程。

公开(公告)号：US20110059429A1

公开(公告)日：2011-03-10

申请号：US12926276

申请日：2010-11-05

申请人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G.M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Dennis J. Steibel ,  Richard Fraser ,  Stanley Harris ,  Douglas Schein

发明人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G.M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Dennis J. Steibel ,  Richard Fraser ,  Stanley Harris ,  Douglas Schein

IPC分类号： A01N1/02

CPC分类号： G06F17/30876 ,  A01N1/02 ,  A01N1/0247 ,  A01N1/0273 ,  H04L67/02

摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

摘要翻译： 器官灌注装置和方法监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。 其他装置包括器官输送器，器官盒和器官诊断装置。 该方法包括在低温和/或正常体温温度下灌注器官，优选在用于器官运输和/或储存的低温器官冲洗之后。 该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。 通过用正常体温温度下的医用流体例如氧合交联血红蛋白的碳酸氢盐医疗液灌注器官，恢复高能量核苷酸（例如ATP）水平来恢复器官存活力。 在灌注中，器官灌注压力优选地响应于设置在置于器官中的管的末端中的传感器，通过气动加压的医用液体储存器进行控制，提供灌注压力微调，超压预防和紧急流量截止。 在低体温模式中，器官用液体灌注，优选地是含有抗氧化剂的简单晶体溶液，间歇地或以缓慢的连续流动。 可以从具有低压头的中间容器将药液输送到器官中，以避免器官过压。 防止过度加压防止或减少对血管内皮衬里和器官组织的损害。 可以自动监测器官的活力，优选通过监测医用流体灌注液的特性。 可以使用控制程序自动控制灌注过程。

公开(公告)号：US06977140B1

公开(公告)日：2005-12-20

申请号：US09537180

申请日：2000-03-29

申请人： Donald R. Owen ,  David C. Kravitz

发明人： Donald R. Owen ,  David C. Kravitz

IPC分类号： A01N1/02 ,  C12M3/00 ,  A01N1/00

CPC分类号： G06F17/30876 ,  A01N1/02 ,  A01N1/0247 ,  A01N1/0273 ,  H04L67/02

摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

摘要翻译： 器官灌注装置和方法监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。 该方法包括在低温和/或正常体温温度下灌注器官，优选在用于器官运输和/或储存的低温器官冲洗之后。 该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。 通过用正常体温温度下的医用流体例如氧合交联血红蛋白的碳酸氢盐医疗液灌注器官，恢复高能量核苷酸（例如ATP）水平来恢复器官存活力。 在灌注中，器官灌注压力优选地响应于设置在置于器官中的管的末端中的传感器，通过气动加压的医用液体储存器进行控制，提供灌注压力微调，超压预防和紧急流量截止。 在低体温模式中，器官用液体灌注，优选地是含有抗氧化剂的简单晶体溶液，间歇地或以缓慢的连续流动。 可以从具有低压头的中间容器将药液输送到器官中，以避免器官过压。 防止过度加压防止或减少对血管内皮衬里和器官组织的损害。 可以自动监测器官的活力，优选通过监测医用流体灌注液的特性。 可以使用控制程序自动控制灌注过程。

公开(公告)号：US20130177897A1

公开(公告)日：2013-07-11

申请号：US13348195

申请日：2012-01-11

申请人： David C. KRAVITZ ,  Peter DEMUYLDER ,  Brian OTTS ,  Stephan MERKLE ,  Jeremiah P. O'LEARY ,  Christopher E. SVENSRUD

发明人： David C. KRAVITZ ,  Peter DEMUYLDER ,  Brian OTTS ,  Stephan MERKLE ,  Jeremiah P. O'LEARY ,  Christopher E. SVENSRUD

IPC分类号： A01N1/02 ,  B65D33/02 ,  B65D33/06

CPC分类号： A01N1/0273 ,  A61B10/0096

摘要： A bag includes an organ transporter compartment to contain an organ transporter disposed in the transporter compartment. The bag may include openings to access portions of the organ transporter, such as a battery or power cable, when the organ transporter is disposed in the bag. The bag may also include a frame and handles. The handles may include structure adapted to mate with handles on the organ transporter. The bag may also include a single cover that provides access to multiple compartments with their own internal covers. Also, the bag may include windows to view documents stored in the bag and/or to view and/or display control panels on the organ transporter.

摘要翻译： 袋子包括器官运送室，用于容纳设置在运输车厢内的器官运送器。 当器官输送器设置在袋中时，该袋可以包括用于进入器官运送器的部分的开口，例如电池或电力电缆。 袋子还可以包括框架和把手。 手柄可以包括适于与器官运送器上的手柄配合的结构。 该袋还可以包括单个盖，其提供通过其自己的内盖进入多个隔间的单个盖。 此外，袋可以包括用于观察存储在袋中的文件的窗口和/或用于观察和/或显示器官运送器上的控制面板。

公开(公告)号：US20120203573A1

公开(公告)日：2012-08-09

申请号：US13427389

申请日：2012-03-22

申请人： Steven L. MAYER ,  David C. KRAVITZ ,  Tracey H. MAYER

发明人： Steven L. MAYER ,  David C. KRAVITZ ,  Tracey H. MAYER

IPC分类号： G06Q50/24 ,  G06F7/04

CPC分类号： G16H20/13 ,  G06F19/00 ,  G06F19/3456 ,  G06F19/3481 ,  G16H40/63 ,  G16Z99/00 ,  Y02A90/22 ,  Y02A90/26

摘要： Methods, systems, and apparatus monitor medication usage data for one patient or a population of patients, which can be processed to determine compliance patterns. Such methods and systems can associate, analyze, organize and present medication usage data, compliance patterns, and correlations between compliance patterns and outcomes data for electronic analysis or analysis by a caretaker, Such methods, systems, and apparatus permit analysis of compliance patterns to enable, for example, establishment or adjustment of safe and effective treatment regimens, and may include feedback systems for ensuring authenticity of medication and/or effects of medication on a patient.

摘要翻译： 方法，系统和设备监测一个患者或患者群体的药物使用数据，其可以被处理以确定依从性模式。 这样的方法和系统可以关联，分析，组织和呈现药物使用数据，合规性模式以及合规性模式与结果数据之间的相关性，以便由看守者进行电子分析或分析。这些方法，系统和装置允许对合规模式进行分析以使能 例如，建立或调整安全有效的治疗方案，并且可以包括用于确保药物的真实性和/或药物对患者的影响的反馈系统。

公开(公告)号：USD664261S1

公开(公告)日：2012-07-24

申请号：US29410727

申请日：2012-01-11

申请人： David C. Kravitz ,  Peter Demuylder ,  Brian Otts ,  Stephan Merkle ,  Jeremiah P. O'Leary ,  Christopher E. Svensrud

设计人： David C. Kravitz ,  Peter Demuylder ,  Brian Otts ,  Stephan Merkle ,  Jeremiah P. O'Leary ,  Christopher E. Svensrud

公开(公告)号：US20110300614A1

公开(公告)日：2011-12-08

申请号：US13137386

申请日：2011-08-10

申请人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G.M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Dennis J. Steibel ,  Richard Fraser ,  Stanley Harris ,  Douglas Schein

发明人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G.M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Dennis J. Steibel ,  Richard Fraser ,  Stanley Harris ,  Douglas Schein

IPC分类号： A01N1/02

CPC分类号： G06F17/30876 ,  A01N1/02 ,  A01N1/0247 ,  A01N1/0273 ,  H04L67/02

摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

公开(公告)号：US20110300611A1

公开(公告)日：2011-12-08

申请号：US13137383

申请日：2011-08-10

申请人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G.M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Dennis J. Steibel ,  Richard Fraser ,  Stanley Harris ,  Douglas Schein

发明人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G.M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Dennis J. Steibel ,  Richard Fraser ,  Stanley Harris ,  Douglas Schein

IPC分类号： A01N1/02

CPC分类号： G06F17/30876 ,  A01N1/02 ,  A01N1/0247 ,  A01N1/0273 ,  H04L67/02

摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

公开(公告)号：US20110183310A1

公开(公告)日：2011-07-28

申请号：US13064497

申请日：2011-03-29

申请人： David C. Kravitz ,  John Brassil ,  Kelvin G.M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Douglas Schein

发明人： David C. Kravitz ,  John Brassil ,  Kelvin G.M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Douglas Schein

IPC分类号： A01N1/02

CPC分类号： A01N1/0273 ,  A01N1/02 ,  A01N1/0247

摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.