公开(公告)号：US4759848A

公开(公告)日：1988-07-26

申请号：US914297

申请日：1986-10-02

申请人： John S. Segura ,  David E. Connor, III ,  Howard D. Brodbeck

发明人： John S. Segura ,  David E. Connor, III ,  Howard D. Brodbeck

IPC分类号： A61L2/02 ,  B01D29/15 ,  B01D29/60 ,  B01D29/88 ,  B01D35/18 ,  B01D61/14 ,  B01D13/00

CPC分类号： B01D61/145 ,  A61L2/022 ,  B01D29/15 ,  B01D35/18 ,  B01D29/60 ,  B01D29/88

摘要： A cryogenic liquid is sterilized by passing it through a microporous filter, while subcooling the liquid. Subcooling virtually eliminates the possiblity of formation of gas bubbles in the liquid, and thereby insures that the desired mass flow of liquid, through the filter, will be maintained. The apparatus used with this invention comprises an insulated tank, filled with cryogenic liquid. A container having a microporous filter disposed therein, is submerged within the tank. The filter can be made of nylon mesh, which is encased within a polypropylene frame. The filter has a pore size of about 0.2 microns or less. The liquid to be sterilized is a saturated cryogenic liquid. The liquid in the tank is held at a temperature lower than that of the liquid to be sterilized, and therefore subcools the liquid being sterilized. The sterilized liquid is then withdrawn directly from the filter container.

摘要翻译： 通过使低温液体通过微孔过滤器，同时使液体过冷而灭菌。 过冷实质上消除了在液体中形成气泡的可能性，从而确保通过过滤器保持所需的液体质量流量。 本发明使用的装置包括一个充满低温液体的隔热箱。 具有设置在其中的微孔过滤器的容器浸没在罐内。 过滤器可以由尼龙网制成，其被包裹在聚丙烯框架内。 该过滤器具有约0.2微米或更小的孔径。 待灭菌的液体是饱和低温液体。 罐中的液体保持在比待灭菌液体的温度低的温度下，从而将被灭菌的液体冷凝。 然后将无菌液体直接从过滤容器中取出。