公开(公告)号：US07141235B2

公开(公告)日：2006-11-28

申请号：US09941395

申请日：2001-08-28

申请人： Leo A. Trevino ,  Ernest George Schutt ,  David H. Klein ,  Thomas E. Tarara ,  Jeffry G. Weers ,  Alexey Kabalnov

发明人： Leo A. Trevino ,  Ernest George Schutt ,  David H. Klein ,  Thomas E. Tarara ,  Jeffry G. Weers ,  Alexey Kabalnov

IPC分类号： A61B8/00

CPC分类号： A61K49/223 ,  A61K49/227

摘要： A gas emulsion forming composition comprising a dry, hollow, particulate, approximately microspherical material permeated with a gas or gas mixture, which upon dissolution in aqueous liquid forms a gas emulsion comprising a plurality of bubbles surrounded by a layer of at least a first and a second surfactant, wherein the first surfactant consists essentially of a phospholipid or mixture of phospholipids having at least one acyl chain which comprises at least 10 carbon atoms, and comprising at least about 5% w/w of total surfactant, and wherein the second surfactant may or may not be a phospholipid and is more water soluble than the first surfactant; kits for preparing such microbubbles; and methods for using such microbubbles as contrast agents.

摘要翻译： 一种气体乳液形成组合物，其包含渗透有气体或气体混合物的干燥，中空，微粒，近似微球的材料，其在溶解在水性液体中时形成气体乳液，所述气体乳液包含多个气泡，所述泡沫被至少第一和第 第二表面活性剂，其中第一表面活性剂基本上由磷脂或具有至少一个包含至少10个碳原子的酰基链，并且包含至少约5％w / w的总表面活性剂的磷脂的混合物组成，并且其中第二表面活性剂可以 或者可能不是磷脂并且比第一表面活性剂更可溶于水; 用于制备这种微泡的试剂盒; 以及使用这种微泡作为造影剂的方法。

公开(公告)号：US06368613B1

公开(公告)日：2002-04-09

申请号：US09217491

申请日：1998-12-21

申请人： Mark A. Walters ,  Ronald M. Hopkins ,  David H. Klein

发明人： Mark A. Walters ,  Ronald M. Hopkins ,  David H. Klein

IPC分类号： A61K910

CPC分类号： A61K9/0026 ,  Y10S514/825 ,  Y10S514/829 ,  Y10S977/929

摘要： Methods for the diagnosis and treatment of articular disorders comprising the use of fluorocarbons are disclosed. The methods provide for the introduction of a fluorocarbon into an articular region to replace or augment natural synovial fluid. The introduced fluorocarbons, which may be in various forms including liquids, gels or emulsions, provide articular lubrication and cushioning which is effective for the treatment of disorders such as osteoarthritis and rheumatoid arthritis. Additionally, the methods of the present invention may be used to provide high resolution articular images, reduce articular inflammation and introduce bioactive agents to the articular region.

摘要翻译： 公开了用于诊断和治疗包括使用碳氟化合物的关节疾病的方法。 所述方法提供将碳氟化合物引入关节区域以替代或增加天然滑液。 引入的碳氟化合物，其可以是各种形式，包括液体，凝胶或乳液，提供关节润滑和缓冲，其对于治疗诸如骨关节炎和类风湿性关节炎的病症是有效的。 此外，本发明的方法可用于提供高分辨率关节图像，减少关节炎症并将生物活性剂引入关节区域。

公开(公告)号：US06280705B1

公开(公告)日：2001-08-28

申请号：US09013357

申请日：1998-01-26

申请人： Leo A. Trevino ,  Ernest George Schutt ,  David H. Klein ,  Thomas E. Tarara ,  Jeffry G. Weers ,  Alexey Kabalnov

发明人： Leo A. Trevino ,  Ernest George Schutt ,  David H. Klein ,  Thomas E. Tarara ,  Jeffry G. Weers ,  Alexey Kabalnov

IPC分类号： A61B813

CPC分类号： A61K49/223 ,  A61K49/227

摘要： A gas emulsion forming composition comprising a dry, hollow, particulate, approximately microspherical material permeated with a gas or gas mixture, which upon dissolution in aqueous liquid forms a gas emulsion comprising a plurality of bubbles surrounded by a layer of at least a first and a second surfactant, wherein the first surfactant consists essentially of a phospholipid or mixture of phospholipids having at least one acyl chain which comprises at least 10 carbon atoms, and comprising at least about 5% w/w of total surfactant, and wherein the second surfactant may or may not be a phospholipid and is more water soluble than the first surfactant; kits for preparing such microbubbles; and methods for using such microbubbles as contrast agents.

摘要翻译： 一种气体乳液形成组合物，其包含渗透有气体或气体混合物的干燥，中空，微粒，近似微球的材料，其在溶解在水性液体中时形成气体乳液，所述气体乳液包含多个气泡，所述泡沫被至少第一和第 第二表面活性剂，其中第一表面活性剂基本上由磷脂或具有至少一个包含至少10个碳原子的酰基链，并且包含至少约5％w / w的总表面活性剂的磷脂的混合物组成，并且其中第二表面活性剂可以 或者可能不是磷脂并且比第一表面活性剂更可溶于水; 用于制备这种微泡的试剂盒; 以及使用这种微泡作为造影剂的方法。

公开(公告)号：US5861175A

公开(公告)日：1999-01-19

申请号：US616260

申请日：1996-03-15

申请人： Mark A. Walters ,  Ronald M. Hopkins ,  David H. Klein

发明人： Mark A. Walters ,  Ronald M. Hopkins ,  David H. Klein

IPC分类号： A61K9/00 ,  A61K9/10 ,  A61K31/755

CPC分类号： A61K9/0026 ,  Y10S514/825 ,  Y10S514/829 ,  Y10S977/929

摘要： Methods for the diagnosis and treatment of articular disorders comprising the use of fluorocarbons are disclosed. The methods provide for the introduction of a fluorocarbon into an articular region to replace or augment natural synovial fluid. The introduced fluorocarbons, which may be in various forms including liquids, gels or emulsions, provide articular lubrication and cushioning which is effective for the treatment of disorders such as osteoarthritis and rheumatoid arthritis. Additionally, the methods of the present invention may be used to provide high resolution articular images, reduce articular inflammation and introduce bioactive agents to the articular region.

公开(公告)号：US5798091A

公开(公告)日：1998-08-25

申请号：US395680

申请日：1995-02-28

申请人： Leo A. Trevino ,  Ernest George Schutt ,  David H. Klein ,  Thomas E. Tarara ,  Jeffry G. Weers ,  Alexey Kabalnov

发明人： Leo A. Trevino ,  Ernest George Schutt ,  David H. Klein ,  Thomas E. Tarara ,  Jeffry G. Weers ,  Alexey Kabalnov

IPC分类号： A61K9/127 ,  A61B8/00 ,  A61K49/00 ,  A61K49/22 ,  A61B8/13

CPC分类号： A61K49/223 ,  A61K49/227

摘要： A gas emulsion forming composition comprising a dry, hollow, particulate, approximately microspherical material permeated with a gas or gas mixture, which upon dissolution in aqueous liquid forms a gas emulsion comprising a plurality of bubbles surrounded by a layer of at least a first and a second surfactant, wherein the first surfactant consists essentially of a phospholipid or mixture of phospholipids having at least one acyl chain which comprises at least 10 carbon atoms, and comprising at least about 5% w/w of total surfactant, and wherein the second surfactant may or may not be a phospholipid and is more water soluble than the first surfactant; kits for preparing such microbubbles; and methods for using such microbubbles as contrast agents.

公开(公告)号：US5628930A

公开(公告)日：1997-05-13

申请号：US967700

申请日：1992-10-27

申请人： Jeffry G. Weers ,  David H. Klein ,  Cindy S. Johnson

发明人： Jeffry G. Weers ,  David H. Klein ,  Cindy S. Johnson

IPC分类号： C07D217/22 ,  A61K9/00 ,  A61K9/113 ,  A61K31/02 ,  A61K31/08 ,  A61K31/47 ,  A61K31/472 ,  A61K47/24 ,  A61K51/00 ,  A61P7/08 ,  A61P11/00 ,  C07C17/42 ,  C07C19/08 ,  C07C21/18 ,  C07C23/20 ,  C07C23/38 ,  C07C43/12 ,  C07C209/90 ,  C07C211/15 ,  B01J13/00

CPC分类号： A61K9/0026 ,  Y10S514/832 ,  Y10S514/937

摘要： Storage stable fluorocarbon emulsions having a continuous aqueous phase and a discontinuous fluorocarbon phase, in which the fluorocarbon phase comprises a major amount of a first fluorocarbon or fluorocarbon mixture, and a minor amount of a second fluorocarbon or fluorocarbon mixture, in which the second fluorocarbon has a molecular weight greater than that of the first fluorocarbon and the second fluorocarbon includes a lipophilic moiety in its structure, whereby the second fluorocarbon serves to promote particle size stability in the emulsion while simultaneously providing favorably short organ retention times when administered to animals in vivo.

摘要翻译： 具有连续水相和不连续碳氟化合物相的储存稳定的碳氟化合物乳液，其中碳氟化合物相包含主要量的第一碳氟化合物或碳氟化合物混合物和少量第二碳氟化合物或碳氟化合物混合物，其中第二碳氟化合物具有 大于第一碳氟化合物和第二氟碳化合物的分子量包括其结构中的亲脂性部分，由此第二种氟碳化合物用于促进乳液中的粒度稳定性，同时在体内施用于动物时同时提供有利的短的器官保留时间。