公开(公告)号：US4096136A

公开(公告)日：1978-06-20

申请号：US773270

申请日：1977-03-01

Applicant: John Stephen Ayers ,  David Roderick Husbands

Inventor： John Stephen Ayers ,  David Roderick Husbands

IPC: G01N33/68 ,  A61K35/14 ,  A61K35/16 ,  B01J20/281 ,  B01J39/22 ,  B01J47/00 ,  G01N30/00 ,  G01N30/88 ,  G01N33/49 ,  G01N33/92 ,  C07G7/00

CPC classification number: B01J39/22 ,  A61K35/16 ,  B01J47/003 ,  G01N30/00 ,  G01N33/491 ,  G01N33/92 ,  Y10S530/83 ,  Y10T436/25125

Abstract: The invention relates to the use of a sulphated ion exchanger to selectively remove lipoproteins from blood plasma or serum. Although the attraction between sulphate groups and proteins has long been recognized it has now unexpectedly been found that cationic ion exchangers whose ion exchange capacity is provided by sulphate groups bind lipoproteins selectively in presence of other plasma or serum proteins and ions when they are equilibrated with solutions containing divalent cations and the same cation is added to the plasma or serum. Types of ion exchanger matrices and applications of the utlity are discussed.

Abstract translation: 本发明涉及使用硫酸化离子交换剂来选择性地从血浆或血清中除去脂蛋白。 虽然长期以来已经认识到硫酸盐基团和蛋白质之间的吸引力已经意外地发现，当离子交换容量由硫酸盐基团提供的阳离子交换剂在其它血浆或血清蛋白质和离子的存在下在选择性地结合脂蛋白时使用溶液平衡 含有二价阳离子并将相同的阳离子加入到血浆或血清中。 讨论了离子交换矩阵的类型及其应用。