公开(公告)号：US12202938B2

公开(公告)日：2025-01-21

申请号：US17424855

申请日：2020-01-30

Applicant: Dow Global Technologies LLC

Inventor： Sven Claessens ,  Alexey Kirilin ,  Van Gaalen Gerrit-Jan ,  Balamurali Sreedhar ,  An Adams

IPC: C08G65/30 ,  B01D15/26 ,  B01D15/42 ,  B01J20/18 ,  B01J20/281 ,  C08G18/08 ,  C08G18/63 ,  C08G65/329 ,  C08G65/333 ,  C08G65/46

Abstract: A process for preparing a copolymer polyol containing a reduced content of residual monomers and volatiles including the steps of: (a) providing at least one copolymer polyol containing a first initial content of residual monomers and volatiles; (b) providing at least one molecular sieve adsorbent; (c) contacting the at least one copolymer polyol with the at least one molecular sieve adsorbent for a period of time and at a temperature sufficient for the at least one molecular sieve adsorbent to adsorb at least a portion of the first initial content of residual monomers and volatiles present in the at least one copolymer polyol to reduce the first initial content of residual monomers and volatiles of the at least one copolymer polyol to form at least one copolymer polyol containing a second reduced content of residual monomers and volatiles; and (d) separating the at least one molecular sieve adsorbent containing a portion of the first initial content residual monomers and volatiles from the at least one copolymer polyol to form at least one copolymer polyol containing a second reduced content of residual monomers and volatiles.

公开(公告)号：US20240189796A1

公开(公告)日：2024-06-13

申请号：US18532153

申请日：2023-12-07

Applicant: CALGON CARBON CORPORATION

Inventor： Jason Paul MAZZOCCOLI ,  Christopher Bennett DIXON ,  Timothy Robert MCCLELLAND ,  Ryan William WALKER

IPC: B01J20/281 ,  B01J20/20 ,  B01J20/30 ,  G01N30/00

CPC classification number: B01J20/281 ,  B01J20/20 ,  B01J20/3078 ,  G01N30/00

Abstract: There is provided a method to characterize a sorbent. The method may provide a sorbent, suspend the sorbent in a fluid, stir the sorbent in the fluid, filter the sorbent from the fluid to isolate a filtrate, measure the electrical conductivity of the filtrate, and measure the alkalinity of the filtrate.

公开(公告)号：US11857948B2

公开(公告)日：2024-01-02

申请号：US16759548

申请日：2018-11-02

Applicant: Dow Global Technologies LLC

Inventor： Rongjuan Cong ,  Albert Parrott ,  Charles Michael Cheatham ,  Janet Goss

IPC: B01J20/281

CPC classification number: B01J20/281 ,  B01J2220/42 ,  B01J2220/54

Abstract: A packing material for chromatography, the packing material comprising coated particles, wherein the coated particles comprise non-porous particles and a portion of the surface area of the non-porous particles is coated with a coating composition comprising graphene and/or graphene oxide.

公开(公告)号：US11839861B2

公开(公告)日：2023-12-12

申请号：US17149613

申请日：2021-01-14

Applicant: Genzyme Corporation

Inventor： Rahul Godawat ,  Veena Warikoo ,  Rohan Patil ,  Konstantin Konstantinov ,  Venkat Kishore Ryakala

IPC: B01J20/281 ,  B01J20/34 ,  B01D15/18 ,  B01D15/20 ,  B01D15/32 ,  B01D15/34 ,  B01D15/36 ,  B01J39/26 ,  B01D15/38 ,  B01J20/26 ,  B01J41/12 ,  B01J41/20 ,  C07K1/16 ,  C07K1/22 ,  A61L2/08 ,  C07K1/18

CPC classification number: B01J20/3441 ,  A61L2/081 ,  B01D15/1864 ,  B01D15/20 ,  B01D15/327 ,  B01D15/34 ,  B01D15/362 ,  B01D15/363 ,  B01D15/3804 ,  B01J20/265 ,  B01J20/281 ,  B01J39/26 ,  B01J41/12 ,  B01J41/20 ,  C07K1/16 ,  C07K1/18 ,  C07K1/22 ,  Y10T29/49826

Abstract: Provided herein are methods of reducing bioburden of (e.g., sterilizing) a chromatography resin that include exposing a container including a composition including a chromatography resin and at least one antioxidant agent and/or chelator to a dose of gamma-irradiation sufficient to reduce the bioburden of the container and the chromatography resin, where the at least one antioxidant agent and/or chelator are present in an amount sufficient to ameliorate the loss of binding capacity of the chromatography resin after/upon exposure to the dose of gamma-irradiation. Also provided are reduced bioburden chromatography columns including the reduced bioburden chromatography resin, compositions including a chromatography resin and at least one chelator and/or antioxidant agent, methods of performing reduced bioburden column chromatography using one of these reduced bioburden chromatography columns, and integrated, closed, and continuous processes for reduced bioburden manufacturing of a purified recombinant protein.

公开(公告)号：US11731106B2

公开(公告)日：2023-08-22

申请号：US16590435

申请日：2019-10-02

Applicant: SHIMADZU CORPORATION

Inventor： Risa Ishii ,  Michio Butsugan ,  Keita Sakurai ,  Yuka Fujito

IPC: B01J20/26 ,  B01D15/20 ,  B01D15/40 ,  G01N30/56 ,  B01J20/28 ,  B01J20/30 ,  C08F20/14 ,  B01J20/281 ,  G01N30/02

CPC classification number: B01J20/267 ,  B01D15/206 ,  B01D15/40 ,  B01J20/281 ,  B01J20/28004 ,  B01J20/3085 ,  C08F20/14 ,  G01N30/56 ,  C08F2810/20 ,  G01N2030/027 ,  G01N2030/565

Abstract: A column packing material for supercritical fluid chromatography which allows good peak shape to be obtained in the analysis of free fatty acids, etc. and in the analysis of agricultural chemicals, etc., and has excellent durability for repeated analysis. The column packing material for supercritical fluid chromatography includes polymer particles containing cross-linked polymer, the degree of swelling of which after absorbing tetrahydrofuran and the degree of swelling of which after absorbing methanol are both 1.4 or less.

公开(公告)号：US11713450B2

公开(公告)日：2023-08-01

申请号：US17328687

申请日：2021-05-24

Applicant: The Trustees of the University of Pennsylvania

Inventor： Martin Lock ,  Mauricio Alvira

IPC: C12N7/02 ,  B01J20/281 ,  B01D15/08 ,  C12N7/00 ,  B01J41/13 ,  C12N15/86 ,  B01J47/022 ,  B01D15/38 ,  C12N15/864 ,  G01N21/33 ,  B01J41/05 ,  B01D15/16 ,  B01D15/36 ,  B01J41/20

CPC classification number: C12N7/02 ,  B01D15/08 ,  B01D15/3804 ,  B01J20/281 ,  B01J41/13 ,  B01J47/022 ,  C12N7/00 ,  C12N15/86 ,  C12N15/8645 ,  G01N21/33 ,  B01D15/166 ,  B01D15/363 ,  B01J41/05 ,  B01J41/20 ,  C12N2750/14143 ,  C12N2750/14151 ,  B01D15/3804 ,  B01D15/363

Abstract: A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the clarified, concentrated supernatant of a rAAV production cell culture. The process utilizes an affinity capture method performed at a high salt concentration followed by an anion exchange resin method performed at high pH to provide rAAV vector particles which are substantially free of rAAV intermediates.

公开(公告)号：US20220362685A1

公开(公告)日：2022-11-17

申请号：US17871086

申请日：2022-07-22

Applicant: SPF Technologies LLC

Inventor： Gaston de los Reyes

IPC: B01D15/22 ,  G01N30/60 ,  B01D15/18 ,  B33Y10/00 ,  B33Y80/00 ,  B01D15/20 ,  G01N30/52 ,  B01J20/281

Abstract: A chromatographic cassette includes a cassette including a chamber, chromatographic media disposed within the cassette chamber, a distribution network fluidly coupled to the chromatographic media and an inlet port and an outlet port coupled to the distribution network. A hyper-productive chromatography technique includes providing a scalable and stackable chromatographic cassette, loading a sample to be processed, operating the scalable chromatographic cassette having an adsorptive chromatographic bed having a volume greater than 0.5 liter by establishing a flow at a linear velocity greater than 500 cm/hr with a residence time of the loading step of less than one minute.

公开(公告)号：US11435359B2

公开(公告)日：2022-09-06

申请号：US17125342

申请日：2020-12-17

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： Shunhai Wang

IPC: G01N33/68 ,  G01N30/46 ,  B01J20/281 ,  G01N30/72 ,  C07K1/16 ,  B01D15/18 ,  C07K1/20 ,  G01N30/88

Abstract: Methods for achieving complete sequence coverage of monoclonal antibodies by trypsin digestion and dual-column LC-MS system are provided. The disclosed method improves upon current techniques for standard peptide mapping.

公开(公告)号：US20220081468A1

公开(公告)日：2022-03-17

申请号：US17477331

申请日：2021-09-16

Applicant: Waters Technologies Corporation

Inventor： Andrew Wyatt Schmudlach ,  Susan Rzewuski ,  Matthew A. Lauber ,  Yeliz Tunc Sarisozen ,  Nicole L. Lawrence ,  Darryl W. Brousmiche

IPC: C07K1/22 ,  C07C277/06 ,  C07C227/40 ,  B01J20/285 ,  B01J20/28 ,  B01J20/283 ,  B01J20/26 ,  B01J20/10 ,  C12N7/00 ,  B01D15/34 ,  B01J20/281

Abstract: The present disclosure is directed to methods for performing size exclusion chromatography. Embodiments of the present disclosure feature methods for improving separations of proteinaceous analytes in size exclusion chromatography, for example, by using low concentrations of amino acids or derivatives thereof in the mobile phase.

公开(公告)号：US20210372973A1

公开(公告)日：2021-12-02

申请号：US17399693

申请日：2021-08-11

Applicant: Northwest Institute of Eco-Environment and Resources, CAS

Inventor： Yingqin WU ,  Yanhong LIU ,  Tong WANG ,  Zuodong WANG ,  Longmiao YUAN ,  Zhiyu WANG

IPC: G01N30/72 ,  B01J20/22 ,  G01N30/16 ,  B01J20/281

Abstract: A method for separating diastereomers of pristane. A pristane sample is prepared, and then injected into a chromatographic instrument equipped with a chiral chromatographic column, where a stationary phase of the chiral chromatographic column has a preset pore size. The pristane diastereomers in the pristane sample are separated by the chiral chromatographic column, and the components produced by the separation of the pristane diastereomers sequentially enter a mass spectrometer for detection and analysis.