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    Prodrugs of carbamate inhibitors of IMPDH
    2.
    发明申请
    Prodrugs of carbamate inhibitors of IMPDH 有权

    公开(公告)号：US20090093639A1

    公开(公告)日：2009-04-09

    申请号：US12228164

    申请日：2008-08-07

    申请人： Dean P. Stamos ,  Randy S. Bethiel

    发明人： Dean P. Stamos ,  Randy S. Bethiel

    IPC分类号： C07D413/12 ,  C07D233/90

    CPC分类号： C07D413/12 ,  A61K38/00 ,  C07K5/06017 ,  C07K5/06026 ,  C07K5/06165

    摘要： The present invention relates to novel compounds, methods of preparing these compounds, and pharmaceutical compositions comprising these compounds. These compounds are carbamate prodrugs that convert to active inhibitors of the IMPDH enzyme in vivo. The compounds and pharmaceutical compositions of this invention are particularly well suited for activation and subsequent inhibition of the IMPDH enzyme activity. Consequently, these prodrugs may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds and compositions of this invention.

    Prodrugs of carbamate inhibitors of IMPDH
    4.
    发明授权
    Prodrugs of carbamate inhibitors of IMPDH 有权
    IMPDH氨基甲酸酯抑制剂的前药

    公开(公告)号：US06395763B1

    公开(公告)日：2002-05-28

    申请号：US09602703

    申请日：2000-06-23

    申请人： Dean P. Stamos ,  Randy S. Bethiel

    发明人： Dean P. Stamos ,  Randy S. Bethiel

    IPC分类号： C07D26332

    CPC分类号： C07D413/12 ,  A61K38/00 ,  C07K5/06017 ,  C07K5/06026 ,  C07K5/06165

    摘要： The present invention relates to novel compounds, methods of preparing these compounds, and pharmaceutical compositions comprising these compounds. These compounds are carbamate prodrugs that convert to active inhibitors of the IMPDH enzyme in vivo. The compounds and pharmaceutical compositions of this invention are particularly well suited for activation and subsequent inhibition of the IMPDH enzyme activity. Consequently, these prodrugs may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds and compositions of this invention.

    摘要翻译： 本发明涉及新化合物，制备这些化合物的方法和包含这些化合物的药物组合物。 这些化合物是在体内转化为IMPDH酶的活性抑制剂的氨基甲酸酯前药。 本发明的化合物和药物组合物特别适用于IMPDH酶活性的活化和随后的抑制。 因此，这些前药可以有利地用作IMPDH介导的过程的治疗剂。 本发明还涉及使用本发明的化合物和组合物来抑制IMPDH的活性的方法。

    Prodrugs of carbamate inhibitors of IMPDH
    5.
    发明授权
    Prodrugs of carbamate inhibitors of IMPDH 有权
    IMPDH氨基甲酸酯抑制剂的前药

    公开(公告)号：US07777069B2

    公开(公告)日：2010-08-17

    申请号：US12228164

    申请日：2008-08-07

    申请人： Dean P. Stamos ,  Randy S. Bethiel

    发明人： Dean P. Stamos ,  Randy S. Bethiel

    IPC分类号： C07D263/32 ,  C07C271/00

    CPC分类号： C07D413/12 ,  A61K38/00 ,  C07K5/06017 ,  C07K5/06026 ,  C07K5/06165

    摘要： The present invention relates to novel compounds, methods of preparing these compounds, and pharmaceutical compositions comprising these compounds. These compounds are carbamate prodrugs that convert to active inhibitors of the IMPDH enzyme in vivo. The compounds and pharmaceutical compositions of this invention are particularly well suited for activation and subsequent inhibition of the IMPDH enzyme activity. Consequently, these prodrugs may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds and compositions of this invention.

    摘要翻译： 本发明涉及新化合物，制备这些化合物的方法和包含这些化合物的药物组合物。 这些化合物是在体内转化为IMPDH酶的活性抑制剂的氨基甲酸酯前药。 本发明的化合物和药物组合物特别适用于IMPDH酶活性的活化和随后的抑制。 因此，这些前药可以有利地用作IMPDH介导的过程的治疗剂。 本发明还涉及使用本发明的化合物和组合物来抑制IMPDH的活性的方法。

    Prodrugs of carbamate inhibitors of IMPDH
    6.
    发明授权
    Prodrugs of carbamate inhibitors of IMPDH 失效
    IMPDH氨基甲酸酯抑制剂的前药

    公开(公告)号：US06825224B2

    公开(公告)日：2004-11-30

    申请号：US10125617

    申请日：2002-04-17

    申请人： Dean P. Stamos ,  Randy S. Bethiel

    发明人： Dean P. Stamos ,  Randy S. Bethiel

    IPC分类号： A61K3142

    CPC分类号： C07D413/12 ,  A61K38/00 ,  C07K5/06017 ,  C07K5/06026 ,  C07K5/06165

    摘要： The present invention relates to novel compounds, methods of preparing these compounds, and pharmaceutical compositions comprising these compounds. These compounds are carbamate prodrugs that convert to active inhibitors of the IMPDH enzyme in vivo. The compounds and pharmaceutical compositions of this invention are particularly well suited for activation and subsequent inhibition of the IMPDH enzyme activity. Consequently, these prodrugs may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds and compositions of this invention.

    摘要翻译： 本发明涉及新化合物，制备这些化合物的方法和包含这些化合物的药物组合物。 这些化合物是在体内转化为IMPDH酶的活性抑制剂的氨基甲酸酯前药。 本发明的化合物和药物组合物特别适用于IMPDH酶活性的活化和随后的抑制。 因此，这些前药可以有利地用作IMPDH介导的过程的治疗剂。 本发明还涉及使用本发明的化合物和组合物来抑制IMPDH的活性的方法。