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1.发明授权Pharmaceutical formulation composed of a polymer blend and an active compound for time-controlled release 有权药物制剂由聚合物共混物和活性化合物组成，用于时间控制释放公开(公告)号：US08653030B2
公开(公告)日：2014-02-18
申请号：US11970028
申请日：2008-01-07
CPC分类号： C07K7/06 , A61K9/7007 , A61K38/12 , A61K47/593 , A61K47/60 , A61K47/645
摘要： A formulation containing a biologically active compound having a chemical structure with hydrogen bonding sites, a first biocompatible, hydrolytically degrading polycarbonate with hydrogen bonding sites and tyrosine-derived diphenol monomer units, and a second biocompatible hydrolytically degrading polymer that is less hydrophobic than the polycarbonate, wherein the second polymer degrades hydrolytically to form acidic degradation products that promote the release of the active compound. Methods for active compound delivery are also disclosed.
摘要翻译： 包含具有氢键结合位点的化学结构的生物活性化合物，具有氢键位点的第一生物相容性，水解降解性聚碳酸酯和酪氨酸衍生的二酚单体单元的制剂，以及比聚碳酸酯疏水性低的第二生物相容性水解降解聚合物， 其中第二聚合物水解降解以形成促进活性化合物释放的酸性降解产物。 还公开了活性化合物递送的方法。
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2.发明申请PHARMACEUTICAL FORMULATION COMPOSED OF A POLYMER BLEND AND AN ACTIVE COMPOUND FOR TIME-CONTROLLED RELEASE 有权用于时间控制释放的聚合物混合物和活性化合物组成的药物制剂公开(公告)号：US20080194469A1
公开(公告)日：2008-08-14
申请号：US11970028
申请日：2008-01-07
CPC分类号： C07K7/06 , A61K9/7007 , A61K38/12 , A61K47/593 , A61K47/60 , A61K47/645
摘要： A formulation containing a biologically active compound having a chemical structure with hydrogen bonding sites, a first biocompatible, hydrolytically degrading polycarbonate with hydrogen bonding sites and tyrosine-derived diphenol monomer units, and a second biocompatible hydrolytically degrading polymer that is less hydrophobic than the polycarbonate, wherein the second polymer degrades hydrolytically to form acidic degradation products that promote the release of the active compound. Methods for active compound delivery are also disclosed.
摘要翻译： 包含具有氢键结合位点的化学结构的生物活性化合物，具有氢键位点的第一生物相容性，水解降解性聚碳酸酯和酪氨酸衍生的二酚单体单元的制剂，以及比聚碳酸酯疏水性低的第二生物相容性水解降解聚合物， 其中第二聚合物水解降解以形成促进活性化合物释放的酸性降解产物。 还公开了活性化合物递送的方法。
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3.发明授权Pharmaceutical formulation composed of a polymer blend and an active compound for time-controlled release 有权药物制剂由聚合物共混物和活性化合物组成，用于时间控制释放公开(公告)号：US07326425B2
公开(公告)日：2008-02-05
申请号：US10169350
申请日：2001-01-02
CPC分类号： C07K7/06 , A61K9/7007 , A61K38/12 , A61K47/593 , A61K47/60 , A61K47/645
摘要： A formulation containing a biologically active compound having a structure with hydrogen bonding sites blended with a first polymer having a structure with complementary hydrogen bonding sites and a second polymer that degrades to form degradation products that promote the release of the active compound from the first polymer.
摘要翻译： 一种含有生物活性化合物的制剂，所述生物活性化合物具有氢键结合位点与具有互补氢键位置的结构的第一聚合物共混的第二聚合物，所述第二聚合物降解以形成促进活性化合物从第一聚合物释放的降解产物。
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公开(公告)号：US20110256206A1
公开(公告)日：2011-10-20
申请号：US13141094
申请日：2009-12-24
IPC分类号： A61K9/00 , A61P31/18 , A61K31/505
CPC分类号： A61K9/0024 , A61K31/505 , A61K47/10 , A61K47/20 , A61K47/26 , A61K47/32
摘要： The present invention relates to an implantable device comprising a biocompatible, biodegradable polymer mixed with TMC278 and with one or more release-enhancing agents selected from the group consisting of poloxamers, polysorbates, and a combination of dimethyl sulfoxide (DMSO) and poly(vinyl pyrrolidone)(PVP).
摘要翻译： 本发明涉及一种可植入装置，其包括与TMC278混合的生物相容性可生物降解的聚合物和一种或多种选自泊洛沙姆，聚山梨醇酯和二甲基亚砜（DMSO）和聚（乙烯基吡咯烷酮）的组合的释放增强剂 ）（PVP）。
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5.发明授权Pharmaceutical formulation for regulating the timed release of biologically active compounds based on a polymer matrix 有权用于调节基于聚合物基质的生物活性化合物的定时释放的药物制剂公开(公告)号：US07521061B2
公开(公告)日：2009-04-21
申请号：US10169410
申请日：2001-01-02
摘要： A formulation containing a biologically active compound having a structure with hydrogen bonding sites is blended with a polymer having a structure with complementary hydrogen bonding sites, the polymer forming hydrolytic degradation products that promote the release of the biologically active compound from the polymer.
摘要翻译： 含有具有氢键合位点结构的生物活性化合物的制剂与具有互补氢键位置结构的聚合物共混，所述聚合物形成促进生物活性化合物从聚合物释放的水解降解产物。
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公开(公告)号：US20080102123A1
公开(公告)日：2008-05-01
申请号：US11588612
申请日：2006-10-27
申请人： Deborah M. Schachter , Yue Zhou
发明人： Deborah M. Schachter , Yue Zhou
IPC分类号： A61K9/14
CPC分类号： A61K9/0024 , A61K9/1647 , A61K9/1658 , A61K45/06
摘要： A self-gelling tunable drug delivery system is disclosed. The self-gelling tunable drug delivery system is comprised of a hydrophilic matrix and a hydrophobic matrix.
摘要翻译： 公开了一种自胶凝可调药物递送系统。 自凝胶可调药物递送系统由亲水基质和疏水性基质组成。
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7.发明授权Degradable removable implant for the sustained release of an active compound 有权用于持续释放活性化合物的可降解的可去除植入物公开(公告)号：US08784858B2
公开(公告)日：2014-07-22
申请号：US13515380
申请日：2010-12-20
IPC分类号： A61F13/00
CPC分类号： A61L31/148 , A61K9/0024 , A61K9/0092 , A61K9/06 , A61K9/14 , A61K9/5031 , A61K9/5084 , A61K31/34 , A61K31/343 , A61K31/505 , A61K45/06 , A61L31/146 , A61K2300/00
摘要： A degradable, removable, pharmaceutical implant for the sustained release of one or more drugs in a subject, wherein the pharmaceutical implant is composed of a tube comprising an outer wall made of a degradable polymer completely surrounding a cavity, wherein the outer wall has a plurality of openings and wherein the cavity contains one or more sets of micro-particles, which micro-particles contain an active agent or a combination of two or more active agents, and wherein the size of the microparticles is selected such that the majority of the microparticles cannot pass through the openings.
摘要翻译： 一种可降解的，可移除的药物植入物，用于在受试者中持续释放一种或多种药物，其中所述药物植入物由包含由完全环绕空腔的可降解聚合物制成的外壁的管组成，其中所述外壁具有多个 的开口，并且其中所述空腔包含一组或多组微粒，所述微粒含有活性剂或两种或更多种活性剂的组合，并且其中所述微粒的尺寸选择为使得大部分微粒 不能通过开口。
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8.发明申请DEGRADABLE REMOVABLE IMPLANT FOR THE SUSTAINED RELEASE OF AN ACTIVE COMPOUND 有权可拆卸的可拆卸植入物用于活性化合物的持续释放公开(公告)号：US20120277690A1
公开(公告)日：2012-11-01
申请号：US13515380
申请日：2010-12-20
IPC分类号： A61M25/00
CPC分类号： A61L31/148 , A61K9/0024 , A61K9/0092 , A61K9/06 , A61K9/14 , A61K9/5031 , A61K9/5084 , A61K31/34 , A61K31/343 , A61K31/505 , A61K45/06 , A61L31/146 , A61K2300/00
摘要： A degradable, removable, pharmaceutical implant for the sustained release of one or more drugs in a subject, wherein the pharmaceutical implant is composed of a tube comprising an outer wall made of a degradable polymer completely surrounding a cavity, wherein the outer wall has a plurality of openings and wherein the cavity contains one or more sets of micro-particles, which micro-particles contain an active agent or a combination of two or more active agents, and wherein the size of the microparticles is selected such that the majority of the microparticles cannot pass through the openings.
摘要翻译： 一种可降解的，可移除的药物植入物，用于在受试者中持续释放一种或多种药物，其中所述药物植入物由包含由完全环绕空腔的可降解聚合物制成的外壁的管组成，其中所述外壁具有多个 的开口，并且其中所述空腔包含一组或多组微粒，所述微粒含有活性剂或两种或更多种活性剂的组合，并且其中所述微粒的尺寸选择为使得大部分微粒 不能通过开口。
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公开(公告)号：US20120148678A1
公开(公告)日：2012-06-14
申请号：US12963012
申请日：2010-12-08
IPC分类号： A61K31/5377 , A61P31/12 , A61K9/50
CPC分类号： A61K9/0024 , A61K9/1647 , A61K47/6951 , B82Y5/00 , Y02A50/411
摘要： We have disclosed an implantable sustained release composition comprising, a biocompatible, biodegradable polymer, a cyclodextrin inclusion complex of a poorly water soluble pharmaceutical agent present, and a plasticizer, where the polymer is the minority phase of the formulation. Furthermore, The we disclose an implantable sustained release composition that provides a detectable plasma level of an otherwise poorly soluble drug for at least 28 days.
摘要翻译： 我们已经公开了一种植入式缓释组合物，其包含生物相容性可生物降解的聚合物，存在的水溶性差的药物的环糊精包合物和增塑剂，其中所述聚合物是制剂的少数阶段。 此外，我们公开了可植入的缓释组合物，其可提供可检测的血浆水平的其他难溶性药物至少28天。
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10.发明申请Pharmaceutical Formulation for Regulating the Timed Release of Biologically Active Compounds Based on a Polymer Matrix 审中-公开用于调节基于聚合物基质的生物活性化合物的定时释放的药物制剂公开(公告)号：US20090285895A1
公开(公告)日：2009-11-19
申请号：US12426902
申请日：2009-04-20
摘要： A formulation containing a biologically active compound having a structure with hydrogen bonding sites is blended with a polymer having a structure with complementary hydrogen bonding sites, the polymer forming hydrolytic degradation products that promote the release of the biologically active compound from the polymer.
摘要翻译： 含有具有氢键合位点结构的生物活性化合物的制剂与具有互补氢键位置结构的聚合物共混，所述聚合物形成促进生物活性化合物从聚合物释放的水解降解产物。
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