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    Biologically Active Compounds with Anti-Angiogenic Properties
    2.
    发明申请
    Biologically Active Compounds with Anti-Angiogenic Properties 审中-公开
    具有抗血管生成特性的生物活性化合物

    公开(公告)号：US20080280837A1

    公开(公告)日：2008-11-13

    申请号：US11547343

    申请日：2005-04-07

    申请人： Judy Halliday ,  Wim Meutermans ,  Gerald Tometzki ,  Tracie E. Ramsdale ,  Johannes Zuegg ,  Bernd Becker ,  Craig Muldoon ,  Declan McKeveney ,  Rajaratnam Premraj ,  Glenn Condie

    发明人： Judy Halliday ,  Wim Meutermans ,  Gerald Tometzki ,  Tracie E. Ramsdale ,  Johannes Zuegg ,  Bernd Becker ,  Craig Muldoon ,  Declan McKeveney ,  Rajaratnam Premraj ,  Glenn Condie

    IPC分类号： A61K31/7034 ,  C12N5/06 ,  A61P9/00

    CPC分类号： A61K31/7008 ,  A61K31/70

    摘要： A method for inhibiting angiogenesis in a subject comprising administering to the subject at least one compound of General Formula (I), wherein the ring or any chiral center(s) may be of any configuration; Z is sulphur, oxygen, CH2, C(O), C(O)HN, NH, NRA or hydrogen, in the case where Z is hydrogen then R1 is not present, RA is selected from the set defined for R1 to R5, X and X′ are independently oxygen or nitrogen providing that at least one X of General Formula (I) is nitrogen, X or X′ may also combine independently with one of R1 to R5 to form an azide, R1 to R5 are independently selected from the following definition which includes but is not limited to H or an alkyl, acyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl substituent of 1 to 20 atoms, which is optionally substituted, and can be branched or linear, and R6 and R7 are hydrogen, or may combine to form a carbonyl function.

    摘要翻译： 一种用于抑制受试者血管发生的方法，其包括向所述受试者施用至少一种通式（I）的化合物，其中所述环或任何手性中心可以是任何构型; Z是硫，氧，CH 2，C（O），C（O）HN，NH，NRA或氢时，在Z是氢的情况下，R1不存在，RA选自为R1至R5定义的集合， X和X'独立地是氧或氮，条件是至少一个通式（I）的X是氮，X或X'也可以独立地与R 1至R 5中的一个组合形成叠氮化物，R 1至R 5独立地选自 包括但不限于H或任选取代的1-20个原子的烷基，酰基，烯基，炔基，杂烷基，芳基，杂芳基，芳烷基或杂芳基烷基取代基，并且可以是支链或直链的以下定义，和 R6和R7是氢，或者可以结合形成羰基官能团。