公开(公告)号：US06949505B1

公开(公告)日：2005-09-27

申请号：US08292782

申请日：1994-08-18

申请人： David C. Rueger ,  Kuber T. Sampath ,  John E. Smart ,  Hermann Oppermann ,  Engin Ozkaynak ,  Charles M. Cohen ,  Dennis Higgins

发明人： David C. Rueger ,  Kuber T. Sampath ,  John E. Smart ,  Hermann Oppermann ,  Engin Ozkaynak ,  Charles M. Cohen ,  Dennis Higgins

IPC分类号： A01N37/18 ,  A61K38/18 ,  C07K14/51

CPC分类号： C07K14/51 ,  A01N1/021 ,  A61K38/00 ,  A61K38/1841 ,  A61K38/185

摘要： Disclosed are methods and compositions for maintaining neural pathways in a mammal including: enhancing survival of neurons at risk of dying; inducing cellular repair of damaged neurons and neural pathways; stimulating neurons to maintain their differentiated phenotype; and promoting dendritic outgrowth, including maintaining dendritic arbors and regenerating dendritic architecture. In one embodiment, the invention provides means for stimulating CAM expression in neurons. The invention also provides means for evaluating the status of nerve tissue, including means for detecting and monitoring neuropathies in a mammal. The methods, devices and compositions include a morphogen or morphogen-stimulating agent provided to the mammal in a therapeutically effective concentration. In another embodiment, the invention provides methods and compositions which include a morphogen or morphogen-stimulating agent, and a nerve trophic factor or nerve trophic factor-stimulating agent at concentrations effective for stimulating dendrite outgrowth. The morphogen and the nerve trophic factor can be admixed in combination.

摘要翻译： 公开了用于在哺乳动物中维持神经通路的方法和组合物，包括：增加有死亡风险的神经元的存活; 诱导损伤的神经元和神经通路的细胞修复; 刺激神经元维持其分化表型; 并促进树突生长，包括保持树枝状树枝和再生树枝状结构。 在一个实施方案中，本发明提供用于刺激神经元中的CAM表达的装置。 本发明还提供用于评估神经组织状态的手段，包括用于检测和监测哺乳动物神经病变的手段。 方法，装置和组合物包括以治疗有效浓度提供给哺乳动物的形态发生剂或形态发生剂。 在另一个实施方案中，本发明提供了包括形态发生剂或形态发生剂刺激剂以及神经营养因子或神经营养因子刺激剂的方法和组合物，其浓度有效刺激枝晶生长。 形态发生剂和神经营养因子可以组合使用。

公开(公告)号：US20060025571A1

公开(公告)日：2006-02-02

申请号：US11226555

申请日：2005-09-13

申请人： David Rueger ,  Kuber Sampath ,  John Smart ,  Hermann Oppermann ,  Engin Ozkaynak ,  Charles Cohen ,  Dennis Higgins

发明人： David Rueger ,  Kuber Sampath ,  John Smart ,  Hermann Oppermann ,  Engin Ozkaynak ,  Charles Cohen ,  Dennis Higgins

IPC分类号： A61K38/18 ,  C07K14/475

CPC分类号： C07K14/51 ,  A01N1/021 ,  A61K38/00 ,  A61K38/1841 ,  A61K38/185

摘要： Disclosed are methods and compositions for maintaining neural pathways in a mammal including: enhancing survival of neurons at risk of dying; inducing cellular repair of damaged neurons and neural pathways; stimulating neurons to maintain their differentiated phenotype; and promoting dendritic outgrowth, including maintaining dendritic arbors and regenerating dendritic architecture. In one embodiment, the invention provides means for stimulating CAM expression in neurons. The invention also provides means for evaluating the status of nerve tissue, including means for detecting and monitoring neuropathies in a mammal. The methods, devices and compositions include a morphogen or morphogen-stimulating agent provided to the mammal in a therapeutically effective concentration. In another embodiment, the invention provides methods and compositions which include a morphogen or morphogen-stimulating agent, and a nerve trophic factor or nerve trophic factor-stimulating agent at concentrations effective for stimulating dendrite outgrowth. The morphogen and the nerve trophic factor can be admixed in combination.

摘要翻译： 公开了用于在哺乳动物中维持神经通路的方法和组合物，包括：增加有死亡风险的神经元的存活; 诱导损伤的神经元和神经通路的细胞修复; 刺激神经元维持其分化表型; 并促进树突生长，包括保持树枝状树枝和再生树枝状结构。 在一个实施方案中，本发明提供用于刺激神经元中的CAM表达的装置。 本发明还提供用于评估神经组织状态的手段，包括用于检测和监测哺乳动物神经病变的手段。 方法，装置和组合物包括以治疗有效浓度提供给哺乳动物的形态发生剂或形态发生剂。 在另一个实施方案中，本发明提供了包括形态发生剂或形态发生剂刺激剂以及神经营养因子或神经营养因子刺激剂的方法和组合物，其浓度有效刺激枝晶生长。 形态发生剂和神经营养因子可以组合使用。