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公开(公告)号：US20110034813A1
公开(公告)日：2011-02-10
申请号：US12903915
申请日：2010-10-13
IPC分类号： A61B5/021 , A61B5/0402 , A61B5/02
CPC分类号： A61B5/02007 , A61B5/02255 , A61B5/029 , A61B5/0456 , A61B5/726
摘要： The present invention provides methods and apparatus for determining a dynamical property of the systemic or pulmonary arterial tree using long time scale information, i.e., information obtained from measurements over time scales greater than a single cardiac cycle. In one aspect, the invention provides a method and apparatus for monitoring cardiac output (CO) from a single blood pressure signal measurement obtained at any site in the systemic or pulmonary arterial tree or from any related measurement including, for example, fingertip photoplethysmography.According to the method the time constant of the arterial tree, defined to be the product of the total peripheral resistance (TPR) and the nearly constant arterial compliance, is determined by analyzing the long time scale variations (greater than a single cardiac cycle) in any of these blood pressure signals. Then, according to Ohm's law, a value proportional to CO may be determined from the ratio of the blood pressure signal to the estimated time constant. The proportional CO values derived from this method may be calibrated to absolute CO, if desired, with a single, absolute measure of CO (e.g., thermodilution). The present invention may be applied to invasive radial arterial blood pressure or pulmonary arterial blood pressure signals which are routinely measured in intensive care units and surgical suites or to noninvasively measured peripheral arterial blood pressure signals or related noninvasively measured signals in order to facilitate the clinical monitoring of CO as well as TPR.
摘要翻译： 本发明提供了使用长时间尺度信息（即从大于单个心动周期的时间尺度的测量获得的信息）来确定全身或肺动脉树的动力特性的方法和装置。 一方面，本发明提供一种用于从在全身或肺动脉树中的任何位置处获得的单个血压信号测量值或任何相关测量（包括例如指尖光体积描记术）来监测心输出量（CO）的方法和装置。 根据该方法，通过分析长时间尺度变化（大于单个心动周期）来确定被定义为总外周阻力（TPR）和几乎恒定的动脉顺应性的乘积的动脉树的时间常数 任何这些血压信号。 然后，根据欧姆定律，可以根据血压信号与估计的时间常数的比率确定与CO成比例的值。 如果需要，从该方法得到的比例CO值可以通过CO的单一绝对测量（例如，热稀释）校准为绝对CO。 本发明可以应用于在重症监护病房和手术套件中常规测量的侵入性桡动脉血压或肺动脉血压信号，或应用于非侵入性测量的外周动脉血压信号或相关非侵入性测量信号，以便于临床监测 的CO以及TPR。
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2.发明授权
公开(公告)号：US6132380A
公开(公告)日：2000-10-17
申请号：US154621
申请日：1998-09-16
CPC分类号： A61B5/412 , A61B5/026 , A61B5/7203 , A61B5/7207 , A61B5/726
摘要： Perfusion measurement method. The method includes detecting a signal emanating from the tissue and processing the signal to detect fluctuations substantially spatially correlated on a length scale less than 1 centimeter. The fluctuations are then analyzed to obtain a measure of perfusion. In one embodiment, the detected fluctuations are substantially correlated with fluctuations of a biological parameter such as the cardiac cycle or the respiratory cycle.
摘要翻译： 灌注测量方法。 该方法包括检测从组织发出的信号，并处理信号以检测在小于1厘米的长度尺度上基本空间上相关的波动。 然后分析波动以获得灌注的量度。 在一个实施例中，检测到的波动与诸如心动周期或呼吸周期的生物参数的波动基本相关。
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公开(公告)号：US09289133B2
公开(公告)日：2016-03-22
申请号：US12903915
申请日：2010-10-13
IPC分类号： A61B5/021 , A61B5/02 , A61B5/0402 , A61B5/029 , A61B5/0225 , A61B5/0456 , A61B5/00
CPC分类号： A61B5/02007 , A61B5/02255 , A61B5/029 , A61B5/0456 , A61B5/726
摘要： The present invention provides methods and apparatus for determining a dynamical property of the systemic or pulmonary arterial tree using long time scale information, i.e., information obtained from measurements over time scales greater than a single cardiac cycle. In one aspect, the invention provides a method and apparatus for monitoring cardiac output (CO) from a single blood pressure signal measurement obtained at any site in the systemic or pulmonary arterial tree or from any related measurement including, for example, fingertip photoplethysmography.According to the method the time constant of the arterial tree, defined to be the product of the total peripheral resistance (TPR) and the nearly constant arterial compliance, is determined by analyzing the long time scale variations (greater than a single cardiac cycle) in any of these blood pressure signals. Then, according to Ohm's law, a value proportional to CO may be determined from the ratio of the blood pressure signal to the estimated time constant. The proportional CO values derived from this method may be calibrated to absolute CO, if desired, with a single, absolute measure of CO (e.g., thermodilution). The present invention may be applied to invasive radial arterial blood pressure or pulmonary arterial blood pressure signals which are routinely measured in intensive care units and surgical suites or to noninvasively measured peripheral arterial blood pressure signals or related noninvasively measured signals in order to facilitate the clinical monitoring of CO as well as TPR.
摘要翻译： 本发明提供了使用长时间尺度信息（即从大于单个心动周期的时间尺度的测量获得的信息）来确定全身或肺动脉树的动力特性的方法和装置。 一方面，本发明提供一种用于从在全身或肺动脉树中的任何位置处获得的单个血压信号测量值或任何相关测量（包括例如指尖光体积描记术）来监测心输出量（CO）的方法和装置。 根据该方法，通过分析长时间尺度变化（大于单个心动周期）来确定被定义为总外周阻力（TPR）和几乎恒定的动脉顺应性的乘积的动脉树的时间常数 任何这些血压信号。 然后，根据欧姆定律，可以根据血压信号与估计的时间常数的比率确定与CO成比例的值。 如果需要，从该方法得到的比例CO值可以通过CO的单一绝对测量（例如，热稀释）校准为绝对CO。 本发明可以应用于在重症监护病房和手术套件中常规测量的侵入性桡动脉血压或肺动脉血压信号，或应用于非侵入性测量的外周动脉血压信号或相关非侵入性测量信号，以便于临床监测 的CO以及TPR。
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4.发明授权Method and apparatus for guiding ablative therapy of abnormal biological electrical excitation 失效引导异常生物电激发的消融治疗的方法和装置公开(公告)号：US06370412B1
公开(公告)日：2002-04-09
申请号：US09535882
申请日：2000-03-28
IPC分类号： A61B504
摘要： This invention involves method and apparatus for guiding ablative therapy of abnormal biological electrical excitation. In particular, it is designed for treatment of cardiac arrhythmias. In the method of this invention electrical signals are acquired from passive electrodes, and an inverse dipole method is used to identify the site of origin of an arrhythmia. The location of the tip of the ablation catheter is similarly localized from signals acquired from the passive electrodes while electrical energy is delivered to the tip of the catheter. The catheter tip is then guided to the site of origin of the arrhythmia, and ablative radio frequency energy is delivered to its tip to ablate the site.
摘要翻译： 本发明涉及用于引导异常生物电激发的消融治疗的方法和装置。 特别地，它被设计用于治疗心律失常。 在本发明的方法中，从无源电极获取电信号，并且使用反向偶极子法来识别心律不齐的起源部位。 消融导管的尖端的位置与从被动电极获得的信号类似地定位，而电能被传送到导管的尖端。 然后将导管尖端引导到心律失常的原点，并将消融射频能量输送到其尖端以烧蚀部位。
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公开(公告)号：US07815578B2
公开(公告)日：2010-10-19
申请号：US10667956
申请日：2003-09-22
IPC分类号： A61B5/02
CPC分类号： A61B5/02007 , A61B5/02255 , A61B5/029 , A61B5/0456 , A61B5/726
摘要： The present invention provides methods and apparatus for determining a dynamical property of the systemic or pulmonary arterial tree using long time scale information, i.e., information obtained from measurements over time scales greater than a single cardiac cycle. In one aspect, the invention provides a method and apparatus for monitoring cardiac output (CO) from a single blood pressure signal measurement obtained at any site in the systemic or pulmonary arterial tree or from any related measurement including, for example, fingertip photoplethysmography.According to the method the time constant of the arterial tree, defined to be the product of the total peripheral resistance (TPR) and the nearly constant arterial compliance, is determined by analyzing the long time scale variations (greater than a single cardiac cycle) in any of these blood pressure signals. Then, according to Ohm's law, a value proportional to CO may be determined from the ratio of the blood pressure signal to the estimated time constant. The proportional CO values derived from this method may be calibrated to absolute CO, if desired, with a single, absolute measure of CO (e.g., thermodilution). The present invention may be applied to invasive radial arterial blood pressure or pulmonary arterial blood pressure signals which are routinely measured in intensive care units and surgical suites or to noninvasively measured peripheral arterial blood pressure signals or related noninvasively measured signals in order to facilitate the clinical monitoring of CO as well as TPR.
摘要翻译： 本发明提供了使用长时间尺度信息（即从大于单个心动周期的时间尺度的测量获得的信息）来确定全身或肺动脉树的动力特性的方法和装置。 一方面，本发明提供一种用于从在全身或肺动脉树中的任何位置处获得的单个血压信号测量值或任何相关测量（包括例如指尖光体积描记术）来监测心输出量（CO）的方法和装置。 根据该方法，通过分析长时间尺度变化（大于单个心动周期）来确定被定义为总外周阻力（TPR）和几乎恒定的动脉顺应性的乘积的动脉树的时间常数 任何这些血压信号。 然后，根据欧姆定律，可以根据血压信号与估计的时间常数的比率确定与CO成比例的值。 如果需要，从该方法得到的比例CO值可以通过CO的单一绝对测量（例如，热稀释）校准为绝对CO。 本发明可以应用于在重症监护病房和手术套件中常规测量的侵入性桡动脉血压或肺动脉血压信号，或应用于非侵入性测量的外周动脉血压信号或相关非侵入性测量信号，以便于临床监测 的CO以及TPR。
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6.发明授权Method and apparatus for guiding ablative therapy of abnormal biological electrical excitation 有权引导异常生物电激发的消融治疗的方法和装置公开(公告)号：US06308093B1
公开(公告)日：2001-10-23
申请号：US09413969
申请日：1999-10-07
IPC分类号： A61B500
摘要： This invention involves method and apparatus for guiding ablative therapy of abnormal biological electrical excitation. In particular, it is designed for treatment of cardiac arrhythmias. In the method of this invention electrical signals are acquired from passive electrodes, and an inverse dipole method is used to identify the site of origin of an arrhytmia. The location of the tip of the ablation catheter is similarly localized from signals acquired from the passive electrodes while electrical energy is delivered to the tip of the catheter. The catheter tip is then guided to the site of origin of the arrhythmia, and ablative radio frequency energy is delivered to its tip to ablate the site.
摘要翻译： 本发明涉及用于引导异常生物电激发的消融治疗的方法和装置。 特别地，它被设计用于治疗心律失常。 在本发明的方法中，从被动电极获取电信号，并且使用反向偶极方法来识别心律的起源部位。 消融导管的尖端的位置与从被动电极获得的信号类似地定位，而电能被传送到导管的尖端。 然后将导管尖端引导到心律失常的原点，并将消融射频能量输送到其尖端以烧蚀部位。
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