Free-flowable directly compressible starch as binder, disintegrant and
filler for compression tablets and hard gelatine capsules
    2.
    发明授权
    Free-flowable directly compressible starch as binder, disintegrant and filler for compression tablets and hard gelatine capsules 失效
    可自由流动的直接可压缩淀粉作为粘合剂,崩解剂和填充剂用于压片和硬明胶胶囊

    公开(公告)号:US6143324A

    公开(公告)日:2000-11-07

    申请号:US112984

    申请日:1998-07-10

    CPC classification number: C08B30/12 A61K9/2059 Y10S514/951 Y10S514/96

    Abstract: A directly compressible starch consisting in an intense white free-flowing powder showing both excellent compression profile and extremely good disintegration properties. This starch is especially designed to be used as a binder in direct compression processes where it yields very hard white tablets at relatively low compression forces. Tablets resulting from the compression of the above mentioned starch disintegrate in an aqueous medium at a very high speed and they additionally exhibit low friability pattern. This free-flowing starch also brings advantages when used as filler and binder in the filling of some hard gelatine capsules especially for these which are filled by pre-compression of the ingredients. This starch is characterized by regular and smooth partially swollen granules which can be either birefringent or non-birefringent. It can be prepared by spray-drying of a partially cooked starch.

    Abstract translation: 一种由强烈的白色自由流动粉末组成的直接可压缩淀粉,显示出优异的压缩特性和极好的崩解性能。 该淀粉特别设计用于直接压缩方法中的粘合剂,其中它以相当低的压缩力产生非常硬的白色片剂。 由上述淀粉的压缩产生的片剂以非常高的速度在水性介质中崩解,并且还显示出低脆性图案。 这种自由流动的淀粉在用作填充一些硬明胶胶囊时的填料和粘合剂也特别适用于通过预先压缩成分而填充的淀粉。 该淀粉的特征在于规则和平滑的部分溶胀的颗粒,其可以是双折射的或非双折射的。 它可以通过喷雾干燥部分熟化的淀粉来制备。

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