公开(公告)号：US5169082A

公开(公告)日：1992-12-08

申请号：US743121

申请日：1991-08-09

申请人： Domingos da Silva ,  Marc Budin

发明人： Domingos da Silva ,  Marc Budin

IPC分类号： B31F5/02 ,  B65H19/10 ,  B65H19/18

CPC分类号： B65H19/1863 ,  B31F5/022 ,  B65H19/105 ,  B65H19/1836 ,  B65H2301/46115 ,  B65H2301/4632 ,  B65H2801/54

摘要： A cylindrical seizing element (3), made up of a fixed tubular part (32) comprising a cylindrical sector-shaped aperture (30) having a series of teeth (34) and of a movable inside part (31) also having a series of teeth (36) interposed between the first series of teeth, seizes the ends of turns of paper previously severed on a fresh reel of paper and brings the strip of paper unwinding from this fresh reel opposite a strip unwinding from an expiring reel. A splicing device comprising two rollers which are pressed against one another, one on each side of the two strips of paper, creates a splice through perforation of the two strips in an arrangement ensuring the strength of the splice. The method and apparatus are designed especially for integration in a single piece of equipment and for reliably joining two strips of paper intended to encircle cigarette filters.

摘要翻译： 一种由固定管状部件（32）构成的圆柱形检查元件（3），其包括具有一系列齿（34）的圆柱形扇形孔（30）和可移动内部部分（31） 插入在第一系列齿之间的齿（36）抓住先前在新鲜卷轴上切断的纸匝的端部，并使从该新鲜卷轴展开的纸条与从过期卷轴退绕的条带相对。 一种拼接装置，包括彼此挤压的两个辊，两个纸条的每一侧上的一个，通过穿过这两个条带的拼接，确保了拼接的强度。 该方法和设备专门设计用于集成在单件设备中，并且可靠地接合用于包围香烟过滤嘴的两条纸。

公开(公告)号：US5018535A

公开(公告)日：1991-05-28

申请号：US268975

申请日：1988-11-09

申请人： Domingos Da Silva ,  Roland Guinnard

发明人： Domingos Da Silva ,  Roland Guinnard

IPC分类号： A24C5/20 ,  B65H19/18

CPC分类号： B65H19/1863 ,  A24C5/20 ,  B65H19/1852 ,  B65H2301/46115 ,  B65H2301/46174 ,  B65H2301/4632 ,  B65H2301/46412 ,  B65H2406/351

摘要： The trailing end (5) of a strip of paper (8) which was wound on a first reel (3) is immobilized by means of suction devices (16, 17, 18) relative to a counterplate (19). The trailing end is severed by means of a cutter (29), the rear portion being discarded by blowing. The leading end of the new strip of paper (11) is then positioned between a punch (20) and the counterplate, immobilized by means of a suction device (18), and joined to the trailing end by interpenetration, brought about by the punch, of the material of two superposed joining areas.

摘要翻译： 卷绕在第一卷轴（3）上的纸条（8）的尾端（5）通过相对于对准板（19）的抽吸装置（16,17,18）被固定。 尾端通过切割器（29）切断，后部通过吹送而被丢弃。 然后将新的纸条（11）的前端定位在冲头（20）和对面板之间，借助于抽吸装置（18）固定，并通过相互渗透连接到后端，由冲头 的两个叠加接合区域的材料。

公开(公告)号：US20110159057A1

公开(公告)日：2011-06-30

申请号：US13060270

申请日：2008-08-22

申请人： Jose Domingos Da Silva Santos ,  Maria Ascensâo Ferreira Da Silva Lopes ,  Marta Alves Da Silva

发明人： Jose Domingos Da Silva Santos ,  Maria Ascensâo Ferreira Da Silva Lopes ,  Marta Alves Da Silva

IPC分类号： A61K9/14 ,  A61K33/42 ,  A61P19/08 ,  B29B9/16 ,  B29C67/00

CPC分类号： A61L27/56 ,  A61L27/425 ,  A61L2430/02 ,  B29B9/06 ,  B29B9/16 ,  B29B2009/166

摘要： The disclosed subject matter refers to hydroxyapatite and bioglass-based pellets of homogeneous size and spherical shape, whose interconnective porous structure, in the micrometer range, allows for an enhanced osteoconductivity and osteointegration, with specific application as a synthetic bone graft and to the respective production process. The production process is based on the pharmaceutical technology of extrusion and spheronization employing a porogenic agent and applying a sinterization stage in the presence of a vitreous liquid phase, which reverts on behalf of a higher reproducibility, superior yield and greater production capacity. Therefore, the disclosed subject matter is directed to the production of hydroxyapatite and bioglass-based pellets with applications in osteoregenerative medicine, particularly in the fields of orthopaedic surgery, maxillofacial surgery, dental surgery, implantology and as tissue engineering scaffolds

摘要翻译： 所公开的主题是指具有均匀尺寸和球形形状的羟基磷灰石和基于生物玻璃的颗粒，其互连多孔结构在微米范围内允许增强的骨传导性和骨整合，具体应用为合成骨移植物，并适用于各自的生产 处理。 该生产工艺基于采用造孔剂的挤出和滚圆化的制药技术，并且在玻璃液相存在下应用烧结阶段，其代表更高的再现性，优异的产量和更大的生产能力。 因此，所公开的主题涉及在骨代谢药物中应用的羟磷灰石和基于生物玻璃的丸剂的生产，特别是在矫形外科，颌面外科，牙科手术，植入术和组织工程支架领域

公开(公告)号：US20110040389A1

公开(公告)日：2011-02-17

申请号：US12936670

申请日：2008-04-07

申请人： José Domingos Da Silva Santos ,  Maria Ascensão Ferreira Da Silva Lopes ,  Cláudia Manuela Da Cunha Ferreira Botelho

发明人： José Domingos Da Silva Santos ,  Maria Ascensão Ferreira Da Silva Lopes ,  Cláudia Manuela Da Cunha Ferreira Botelho

IPC分类号： A61F2/28

CPC分类号： A61L27/425 ,  A61L2430/02

摘要： The disclosed invention is based on hydroxyapatite, biocompatible glass and silicon, aiming to develop an improved bone substitute, which presents higher mechanical resistance, bioactivity and osteoregeneration, and susceptible of being used in several medical and surgical fields, with application in the treatment of bone disease caused by trauma or genetic factors, as osteoconductive support for cellular growth. The abovementioned bone substitute comprises hydroxyapatite, a biocompatible glass of the P2O5—CaO system in a percentage up to 10 wt % relatively to the hydroxyapatite weight, and a silicon source in a concentration up to 10 wt % relatively to hydroxyapatite and biocompatible glass weight. The preparation process of the disclosed bone substitute consists of liquid phase sintering of a homogeneous mixture of hydroxyapatite, biocompatible glass and silicon source preferentially within a temperature range of 1100-13500 C, which allows glass melting and fusion throughout hydroxyapatite structure leading to the occurrence of several ionic substitutions.

摘要翻译： 所公开的发明基于羟基磷灰石，生物相容性玻璃和硅，旨在开发出改进的骨替代物，其具有更高的机械阻力，生物活性和骨代谢，并且易于用于几个医疗和外科领域，并且用于治疗骨 由创伤或遗传因素引起的疾病，作为细胞生长的骨传导支持。 上述骨替代物包括相对于羟基磷灰石重量，高达10重量％的相对于羟基磷灰石重量的比例的羟基磷灰石，P2O5-CaO系的生物相容性玻璃和相对于羟基磷灰石和生物相容性玻璃重量高达10重量％的硅源。 所公开的骨替代物的制备过程包括在1100-13500℃的温度范围内优选羟基磷灰石，生物相容性玻璃和硅源的均相混合物的液相烧结，其允许玻璃熔化和融合贯穿羟基磷灰石结构，导致发生 几个离子取代。

公开(公告)号：US06312468B1

公开(公告)日：2001-11-06

申请号：US09147733

申请日：1999-08-09

申请人： Serena Michelle Best ,  William Bonfield ,  Iain Ronald Gibson ,  Lakhan Jee Jha ,  Jose Domingos Da Silva Santos

发明人： Serena Michelle Best ,  William Bonfield ,  Iain Ronald Gibson ,  Lakhan Jee Jha ,  Jose Domingos Da Silva Santos

IPC分类号： A01F228

CPC分类号： C01B33/20 ,  A61F2310/00293 ,  A61L27/12

摘要： The present invention provides a synthetic silicon-substituted apatite or hydroxyapatite which comprises 0.1% to 5% by weight of silicon. The silicon-substituted apatite or hydroxyapatite may be used as a synthetic bone material for use in bone substitution, implants, fillers and cements, coatings for metallic implants, and for making hydroxyapatite-polymer composites. The silicon-substituted apatite is prepared by reacting a calcium salt or calcium hydroxide with orthophosphoric acid or a salt of orthophosphoric acid in the presence of a silicon-containing compound, the molar ratio of calcium ions to phosphorous-containing ions being from 1:0.5 to 1:0.7 and the molar ratio of calcium ions to silicon-containing ions being at least 1:0.2, whereby a precipitate of a silicon-substituted apatite is formed. On heating and/or sintering the silicon-substituted apatite at a temperature of from 500° C. to 1400° C. part or substantially all of the silicon-substituted apatite transforms to silicon-substituted hydroxyapatite.

摘要翻译： 本发明提供一种合成硅取代磷灰石或羟基磷灰石，其包含0.1％至5％重量的硅。 硅取代的磷灰石或羟基磷灰石可以用作用于骨替代，植入物，填充剂和水泥，金属植入物的涂层和用于制备羟基磷灰石 - 聚合物复合材料的合成骨材料。 硅取代的磷灰石是通过在含硅化合物存在下使钙盐或氢氧化钙与正磷酸或正磷酸盐反应制备的，钙离子与含磷离子的摩尔比为1:0.5 至1：0.7，并且钙离子与含硅离子的摩尔比为至少1:0.2，由此形成硅取代磷灰石的沉淀。 在500℃至1400℃的温度下加热和/或烧结硅取代的磷灰石，部分或基本上全部硅取代的磷灰石转化为硅取代的羟基磷灰石。

公开(公告)号：US4995406A

公开(公告)日：1991-02-26

申请号：US316224

申请日：1989-02-27

申请人： Domingos da Silva

发明人： Domingos da Silva

IPC分类号： B65H19/10

CPC分类号： B65H19/105 ,  B65H2301/41361 ,  B65H2301/41734 ,  B65H2301/543

摘要： A carriage (6) is moved so that the periphery of a roller (4) rests against the reel (3). The blade (14) of a knife (5) cuts the closing belt of the reel and a few of the outer turns of the strip. The roller is started up so that the scraps are drawn into a device (8) by suction, the free end of the strip also entering this device. The suction device pivots downward so that the free portion of the strip comes to rest upon a presentation block (54) which has meanwhile been advanced.

摘要翻译： 托架（6）移动，使得辊（4）的周边靠在卷轴（3）上。 刀（5）的刀片（14）切割卷轴的封闭带和条的几个外圈。 辊子被启动，使得废料通过抽吸被吸入装置（8）中，条带的自由端也进入该装置。 抽吸装置向下枢转，使得带的自由部分搁置在同时进行的展示块（54）上。