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公开(公告)号：US06482924B1
公开(公告)日：2002-11-19
申请号：US09461920
申请日：1999-12-15
IPC分类号： C07K100
CPC分类号： C12N9/12 , A61K39/00 , C07K14/20 , C12N9/1048 , C12N9/1051 , Y02A50/48 , Y10S530/806 , Y10S530/825
摘要： Four antigenic preparations are provided, each of which contains a different protein from Leptospira which can be used immunologically in vaccines for leptospirosis caused by this organism. Also provided in the invention are polynucleotides encoding these four proteins and antibodies which bind the proteins for use in the diagnosis of leptospirosis.
摘要翻译： 提供四种抗原制剂，每种抗原制剂含有来自钩端螺旋体的不同蛋白质，其可以在疫苗中免疫用于由该生物体引起的钩端螺旋体病。 本发明还提供编码这四种蛋白质的多核苷酸和结合蛋白质的抗体，用于诊断钩端螺旋体病。
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公开(公告)号：US06800734B2
公开(公告)日：2004-10-05
申请号：US10255018
申请日：2002-09-25
IPC分类号： C07K100
CPC分类号： C12N9/12 , A61K39/00 , C07K14/20 , C12N9/1048 , C12N9/1051 , Y02A50/48 , Y10S530/806 , Y10S530/825
摘要： Four antigenic preparations are provided, each of which contains a different protein from Leptospira which can be used immunologically in vaccines for leptospirosis caused by this organism. Also provided in the invention are polynucleotides encoding these four proteins and antibodies which bind the proteins for use in the diagnosis of leptospirosis.
摘要翻译： 提供四种抗原制剂，每种抗原制剂含有来自钩端螺旋体的不同蛋白质，其可以在疫苗中免疫用于由该生物体引起的钩端螺旋体病。 本发明还提供编码这四种蛋白质的多核苷酸和结合蛋白质的抗体，用于诊断钩端螺旋体病。
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公开(公告)号：US07393535B2
公开(公告)日：2008-07-01
申请号：US10953979
申请日：2004-09-29
IPC分类号： A61K39/116
CPC分类号： A61K39/102 , A61K39/0241 , A61K39/099 , A61K39/39 , A61K2039/521 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , Y10S424/825
摘要： The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local reactions to the vaccine in the injected animal.
摘要翻译： 本发明涉及含有卵磷脂，油和两亲性表面活性剂并且能够形成稳定的水包油乳液疫苗以使局部对注射动物中疫苗的反应最小化的佐剂。
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公开(公告)号：US06733754B2
公开(公告)日：2004-05-11
申请号：US10389139
申请日：2003-03-13
IPC分类号： A61K3900
CPC分类号： A61K39/102 , A61K39/0241 , A61K39/099 , A61K39/39 , A61K2039/521 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , Y10S424/825
摘要： The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local reactions to the vaccine in the injected animal.
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公开(公告)号：US06572861B1
公开(公告)日：2003-06-03
申请号：US09489713
申请日：2000-01-24
IPC分类号： A61K39116
CPC分类号： A61K39/102 , A61K39/0241 , A61K39/099 , A61K39/39 , A61K2039/521 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , Y10S424/825
摘要： The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local reactions to the vaccine in the injected animal.
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公开(公告)号：US06814971B2
公开(公告)日：2004-11-09
申请号：US10388947
申请日：2003-03-13
IPC分类号： A61K3910
CPC分类号： A61K39/102 , A61K39/0241 , A61K39/099 , A61K39/39 , A61K2039/521 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , Y10S424/825
摘要： The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local reactions to the vaccine in the injected animal.
摘要翻译： 本发明涉及含有卵磷脂，油和两亲性表面活性剂并且能够形成稳定的水包油乳液疫苗以使局部对注射动物中疫苗的反应最小化的佐剂。
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