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11 条记录 (耗时 0.023 秒)

    Method of preparing gram-negative bacterial vaccines
    6.
    发明授权
    Method of preparing gram-negative bacterial vaccines 失效
    革兰氏阴性细菌疫苗的制备方法

    公开(公告)号：US5616328A

    公开(公告)日：1997-04-01

    申请号：US240649

    申请日：1994-07-11

    申请人： David S. Roberts ,  Donald A. Dearwester ,  Leroy A. Swearingin

    发明人： David S. Roberts ,  Donald A. Dearwester ,  Leroy A. Swearingin

    IPC分类号： A61K39/02 ,  A61K39/102 ,  A61K39/112 ,  A61K39/108 ,  A61K39/10 ,  C07K1/00

    CPC分类号： A61K39/102 ,  A61K39/0258

    摘要： There is provided by this invention a novel method of preparing Gram-negative bacterial vaccines. The method comprises providing a concentrated Gram-negative bacterial antigenic preparation,adsorbing the preparation with a mineral carrier capable of binding free-endotoxin in the antigenic preparation in an amount effective to produce optimal binding of endotoxin and antigen and diluting the adsorbed preparation for use in a vaccine. Also provided by this invention is a vaccine produced by the method of this invention. Also provided by this invention is a Gram-negative bacterial vaccine wherein the improvement comprises a concentration of mineral carrier in the vaccine which is less than 5.0% v/v. Also provided by this invention is a Gram-negative bacterial vaccine comprising a mineral carrier wherein the amount of the mineral carrier in the vaccine has been predetermined by the method of this invention. Also provided by this invention is a method of vaccinating an animal against Gram-negative bacterial infections comprising administering to the animal an effective amount of a vaccine of this invention.

    摘要翻译： PCT No.PCT / US92 / 09944 Sec。 371日期：1994年7月11日 102（e）日期1994年7月11日PCT 1991年11月13日PCT PCT。 公开号WO93 / 10216 PCT 日期1993年5月27日本发明提供了一种制备革兰氏阴性细菌疫苗的新方法。 该方法包括提供浓缩的革兰氏阴性细菌抗原制剂，用能有效产生内毒素和抗原的最佳结合的量吸附具有能够在抗原制剂中结合游离内毒素的矿物载体的制剂，并稀释用于 一种疫苗 本发明还提供了通过本发明的方法生产的疫苗。 本发明还提供革兰氏阴性细菌疫苗，其中改进包括疫苗中矿物质载体的浓度小于5.0％v / v。 本发明还提供革兰氏阴性细菌疫苗，其包含矿物质载体，其中疫苗中矿物质载体的量已经通过本发明的方法预先确定。 本发明还提供一种针对革兰氏阴性细菌感染疫苗接种动物的方法，包括向动物施用有效量的本发明的疫苗。

    Method and apparatus for hydroponic gardening
    9.
    发明授权
    Method and apparatus for hydroponic gardening 失效
    水耕园艺的方法和装置

    公开(公告)号：US5097627A

    公开(公告)日：1992-03-24

    申请号：US475161

    申请日：1990-02-05

    申请人： David S. Roberts

    发明人： David S. Roberts

    IPC分类号： A01G31/04

    CPC分类号： A01G31/045 ,  Y02P60/216

    摘要： Plants are hydroponically grown in a cellular water table provided with divergent grow lines along which plants are moved in plant holders. The grow lines are arranged to provide spacing between adajcent rows of plants as plants mature. Within each grow line is a variable pitch screw arrangement which provides for increased spacing between adjacent plants in a grow line as the plants mature. Four-way spacing is provided for both the leaves of the plants and their roots as the plants are suspended over the cellular water table. Maintenance of the system is facilitated by a crawl space beneath the water table which allows access to removable bottom panels of the individual cells within the water table. Plants are cultivated and serviced from the top by a man carrier system. CO.sub.2 enriched air and/or pesticides are supplied directly to the undersides of the plants by a conduit system provided within each grow line. Nutrient enriched water is provided to the roots of the plants by a closed loop fluid circulation system.

    摘要翻译： 植物在具有不同生长线的细胞水表中水培生长，植物在植物保持器中移动植物。 生长线被布置为当植物成熟时在植物的连接排之间提供间隔。 在每个生长线内是一种可变螺距螺旋装置，其随着植物的成熟而在生长线中相邻植物之间的间隔增加。 当植物悬浮在细胞水表上时，为植物的叶子及其根部提供四向间距。 通过水位下方的爬行空间来促进系统的维护，该爬行空间允许进入水表内的各个单元的可移除底板。 植物从顶部由人运输系统进行耕种和服务。 二氧化碳浓缩空气和/或农药通过在每条生长线内提供的导管系统直接供应给植物的下面。 营养丰富的水通过闭环流体循环系统提供给植物的根部。

    Multicomponent clostridial vaccines using saponin adjuvants
    10.
    发明授权
    Multicomponent clostridial vaccines using saponin adjuvants 失效
    使用皂苷佐剂的多组分梭菌疫苗

    公开(公告)号：US6083512A

    公开(公告)日：2000-07-04

    申请号：US536970

    申请日：1995-09-29

    申请人： David S. Roberts

    发明人： David S. Roberts

    IPC分类号： A61K39/08 ,  A61P31/04

    CPC分类号： A61K39/08 ,  A61K2039/55577 ,  Y10S435/842 ,  Y10S514/885

    摘要： Novel multicomponent clostridial vaccine formulations using readily dispersible, non-depot adjuvants, such as saponin, are disclosed. The vaccines can be administered to cattle intramusculary or subcutaneously without the severe persistent local reactions, such as granulomas, abscesses, and scarring, normally seen with other multicomponent clostridial vaccines.

    摘要翻译： 公开了使用易分散的非贮库佐剂（如皂角苷）的新型多组分梭菌疫苗制剂。 疫苗可以在肌内或皮下施用，而不会发生严重的持续性局部反应，例如肉芽肿，脓肿和瘢痕形成，通常与其他多组分梭菌疫苗一起观察。