公开(公告)号：US20130338650A1

公开(公告)日：2013-12-19

申请号：US13919547

申请日：2013-06-17

申请人： James V. Jester ,  Tibor Juhasz ,  Donald J. Brown ,  Dongyui Chai ,  Moritz Winkler

发明人： James V. Jester ,  Tibor Juhasz ,  Donald J. Brown ,  Dongyui Chai ,  Moritz Winkler

IPC分类号： A61F9/008

CPC分类号： A61F9/00802 ,  A61F9/008 ,  A61F9/00804 ,  A61F9/00825 ,  A61F2009/00872 ,  A61F2009/00893 ,  A61F2009/00895 ,  A61N5/062

摘要： The embodiments include method of nonlinear optical photodynamic therapy of tissue including the steps of providing pulsed infrared laser light for two-photon excited fluorescence tissue exposure, and selectively focusing the pulsed infrared laser light within the tissue at a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue. The invention is also directed to an apparatus for performing nonlinear optical photodynamic therapy of tissue including a pulsed infrared laser for providing two-photon excited fluorescence beam tissue exposure, a scanner for selectively and controllably moving the tissue and the beam relative to each other, and optics for selectively focusing the pulsed infrared laser light within the tissue at a point in a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue.

公开(公告)号：US09095414B2

公开(公告)日：2015-08-04

申请号：US13919547

申请日：2013-06-17

申请人： James V. Jester ,  Tibor Juhasz ,  Donald J. Brown ,  Dongyui Chai ,  Moritz Winkler

发明人： James V. Jester ,  Tibor Juhasz ,  Donald J. Brown ,  Dongyui Chai ,  Moritz Winkler

IPC分类号： A61B18/20 ,  A61F9/008 ,  A61F9/01 ,  A61N5/06

CPC分类号： A61F9/00802 ,  A61F9/008 ,  A61F9/00804 ,  A61F9/00825 ,  A61F2009/00872 ,  A61F2009/00893 ,  A61F2009/00895 ,  A61N5/062

摘要： The embodiments include method of nonlinear optical photodynamic therapy of tissue including the steps of providing pulsed infrared laser light for two-photon excited fluorescence tissue exposure, and selectively focusing the pulsed infrared laser light within the tissue at a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue. The invention is also directed to an apparatus for performing nonlinear optical photodynamic therapy of tissue including a pulsed infrared laser for providing two-photon excited fluorescence beam tissue exposure, a scanner for selectively and controllably moving the tissue and the beam relative to each other, and optics for selectively focusing the pulsed infrared laser light within the tissue at a point in a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue.

摘要翻译： 实施例包括组织的非线性光学光动力学治疗方法，包括以下步骤：为双光子激发荧光组织暴露提供脉冲红外激光，并且将聚焦平面上的组织内的脉冲红外激光选择性聚焦以激活光敏剂 在组织中高度分辨的轴向和横向空间结构域内产生自由基。 本发明还涉及一种用于执行包括用于提供双光子激发的荧光束组织暴露的脉冲红外激光的组织的非线性光学光学治疗的装置，用于选择性地和可控地移动组织和束相对于彼此的扫描仪，以及 用于选择性地将脉冲红外激光在聚焦平面中的一个点聚焦在组织内以激活光敏剂以在组织内的高度分辨的轴向和横向空间域内产生自由基的光学元件。