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    Nonlinear optical photodynamic therapy (NLO-PDT) of the cornea
    2.
    发明授权
    Nonlinear optical photodynamic therapy (NLO-PDT) of the cornea 有权
    非线性光学光动力疗法（NLO-PDT）的角膜

    公开(公告)号：US09095414B2

    公开(公告)日：2015-08-04

    申请号：US13919547

    申请日：2013-06-17

    申请人： James V. Jester ,  Tibor Juhasz ,  Donald J. Brown ,  Dongyui Chai ,  Moritz Winkler

    发明人： James V. Jester ,  Tibor Juhasz ,  Donald J. Brown ,  Dongyui Chai ,  Moritz Winkler

    IPC分类号： A61B18/20 ,  A61F9/008 ,  A61F9/01 ,  A61N5/06

    CPC分类号： A61F9/00802 ,  A61F9/008 ,  A61F9/00804 ,  A61F9/00825 ,  A61F2009/00872 ,  A61F2009/00893 ,  A61F2009/00895 ,  A61N5/062

    摘要： The embodiments include method of nonlinear optical photodynamic therapy of tissue including the steps of providing pulsed infrared laser light for two-photon excited fluorescence tissue exposure, and selectively focusing the pulsed infrared laser light within the tissue at a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue. The invention is also directed to an apparatus for performing nonlinear optical photodynamic therapy of tissue including a pulsed infrared laser for providing two-photon excited fluorescence beam tissue exposure, a scanner for selectively and controllably moving the tissue and the beam relative to each other, and optics for selectively focusing the pulsed infrared laser light within the tissue at a point in a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue.

    摘要翻译： 实施例包括组织的非线性光学光动力学治疗方法，包括以下步骤：为双光子激发荧光组织暴露提供脉冲红外激光，并且将聚焦平面上的组织内的脉冲红外激光选择性聚焦以激活光敏剂 在组织中高度分辨的轴向和横向空间结构域内产生自由基。 本发明还涉及一种用于执行包括用于提供双光子激发的荧光束组织暴露的脉冲红外激光的组织的非线性光学光学治疗的装置，用于选择性地和可控地移动组织和束相对于彼此的扫描仪，以及 用于选择性地将脉冲红外激光在聚焦平面中的一个点聚焦在组织内以激活光敏剂以在组织内的高度分辨的轴向和横向空间域内产生自由基的光学元件。

    NONLINEAR OPTICAL PHOTODYNAMIC THERAPY (NLO-PDT) OF THE CORNEA
    3.
    发明申请
    NONLINEAR OPTICAL PHOTODYNAMIC THERAPY (NLO-PDT) OF THE CORNEA 审中-公开
    CORNEA的非线性光学光电疗法（NLO-PDT）

    公开(公告)号：US20120330291A1

    公开(公告)日：2012-12-27

    申请号：US13523058

    申请日：2012-06-14

    申请人： James V. Jester ,  Tibor Juhasz ,  Donald J. Brown ,  Dongyul Chai ,  Moritz Winkler

    发明人： James V. Jester ,  Tibor Juhasz ,  Donald J. Brown ,  Dongyul Chai ,  Moritz Winkler

    IPC分类号： A61F9/01

    CPC分类号： A61F9/008 ,  A61F9/00825 ,  A61F2009/00872 ,  A61F2009/00893 ,  A61F2009/00895

    摘要： The embodiments include method of nonlinear optical photodynamic therapy of tissue including the steps of providing pulsed infrared laser light for two-photon excited fluorescence tissue exposure, and selectively focusing the pulsed infrared laser light within the tissue at a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue. The invention is also directed to an apparatus for performing nonlinear optical photodynamic therapy of tissue including a pulsed infrared laser for providing two-photon excited fluorescence beam tissue exposure, a scanner for selectively and controllably moving the tissue and the beam relative to each other, and optics for selectively focusing the pulsed infrared laser light within the tissue at a point in a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue.

    摘要翻译： 实施例包括组织的非线性光学光动力学治疗方法，包括以下步骤：为双光子激发荧光组织暴露提供脉冲红外激光，并且将聚焦平面上的组织内的脉冲红外激光选择性聚焦以激活光敏剂 在组织中高度分辨的轴向和横向空间结构域内产生自由基。 本发明还涉及一种用于执行包括用于提供双光子激发的荧光束组织暴露的脉冲红外激光的组织的非线性光学光学治疗的装置，用于选择性地和可控地移动组织和束相对于彼此的扫描仪，以及 用于选择性地将脉冲红外激光在聚焦平面中的一个点聚焦在组织内以激活光敏剂以在组织内的高度分辨的轴向和横向空间域内产生自由基的光学元件。

    Adapter device for tools of an abrasive blasting system
    4.
    发明授权
    Adapter device for tools of an abrasive blasting system 失效
    用于喷砂系统工具的适配器

    公开(公告)号：US4395850A

    公开(公告)日：1983-08-02

    申请号：US203717

    申请日：1980-11-03

    申请人： Donald J. Brown

    发明人： Donald J. Brown

    IPC分类号： B24C3/06 ,  B24C5/02 ,  B24C5/04

    CPC分类号： B24C5/02 ,  B24C3/065

    摘要： A surface treating adapter device for use in combination with a recirculating abrading device includes an adapter housing affording a hollow cup-shaped chamber, an aperture in the housing to receive the discharge nozzle of an abrasive gun, an exhaust outlet including means for detachably engaging a low pressure line from the abrading device, interchangeable hollow working tool members, and tubular connecting members releasably and adjustably joining the adapter housing and a selected one of the tool members. The tool members which contact the surface to be abraded are each of varying configuration for accommodating surfaces of varying contour and for making a sealing engagement therewith. The abrading operation is performed within the confines of the tool member being used. Abrasive is introduced through the housing aperture and impinges upon the surface area enclosed by the tool member. The scale and debris, including the spent abrasive, are then drawn through the chamber of the housing and through the exhaust outlet to the abrading device, and there separated.

    摘要翻译： 一种与再循环研磨装置组合使用的表面处理适配器装置包括：适配器壳体，其提供中空杯状室;壳体中的开口，用于容纳研磨枪的排出喷嘴;排气口，包括用于可拆卸地接合 研磨装置的低压管线，可互换的中空加工工具构件和可释放地并可调节地连接适配器壳体和所选择的一个工具构件的管状连接构件。 接触被磨削表面的工具构件各自具有不同的构造，用于容纳变化轮廓的表面并与其形成密封接合。 在所使用的工具构件的范围内执行研磨操作。 研磨剂通过壳体孔引入并撞击在由工具构件包围的表面区域上。 然后，包括废磨料的氧化皮和碎屑通过壳体的腔室并通过排气出口被吸入研磨装置，并且分离。

    Portable abrading cabinet device for recycling abrasive blasting system
    5.
    发明授权
    Portable abrading cabinet device for recycling abrasive blasting system 失效
    用于回收喷砂系统的便携式研磨柜装置

    公开(公告)号：US4375740A

    公开(公告)日：1983-03-08

    申请号：US203714

    申请日：1980-11-03

    申请人： Donald J. Brown

    发明人： Donald J. Brown

    IPC分类号： B24C3/06 ,  B24C5/02

    CPC分类号： B24C3/065 ,  B24C5/02

    摘要： A portable abrading cabinet device is provided for use in a recycling abrasive blasting system. The cabinet device includes a cup-shaped housing affording an inner blasting chamber. The forward open end of the housing has a peripheral resilient seal to provide airtight engagement with the surface to be abraded. The housing has an inlet aperture for the barrel of a sand blasting gun which delivers rapidly moving abrasive material to the surface to be worked. A funnel-shaped exhaust means in the housing terminates in a fitting which detachably receives a conduit connected to accommodate an external source of vacuum so that spent abrasive and debris may be removed from the inner blasting chamber of the cabinet housing. A transparent window member in the housing permits an operator to observe the abrading operation, the window member being partially shielded by a pair of deflectors which redirect ricocheting abrasive and debris within the cabinet housing. To further aid the observation of the operation, illuminating means are provided within the cabinet. The abrasive is introduced into, and recycled from, the cabinet housing by an appropriate external blasting system.

    摘要翻译： 提供了一种便携式研磨柜装置，用于回收磨料喷砂系统。 橱柜装置包括一个提供内部爆破室的杯形壳体。 壳体的前开口端具有外围的弹性密封件，以与待磨损的表面提供气密接合。 壳体具有用于喷砂枪的枪管的入口孔，其将快速移动的研磨材料输送到待加工的表面。 壳体中的漏斗形排气装置终止于可拆卸地接收连接以适应外部真空源的导管的配件，从而可以将废磨料和碎屑从机壳外壳的内部喷射室移除。 壳体中的透明窗构件允许操作者观察研磨操作，窗构件被一对偏转器部分地屏蔽，所述导向器将壳体内的磨料和碎屑重新引导。 为了进一步帮助观察操作，在机柜内提供照明装置。 研磨剂通过适当的外部爆破系统引入机柜外壳并从其再循环。

    Cabinet for use in abrasive blasting system
    6.
    发明授权
    Cabinet for use in abrasive blasting system 失效
    用于喷砂系统的机柜

    公开(公告)号：US4300318A

    公开(公告)日：1981-11-17

    申请号：US116011

    申请日：1980-01-28

    申请人： Donald J. Brown

    发明人： Donald J. Brown

    IPC分类号： B24C3/02 ,  B24C3/04 ,  B24C9/00

    CPC分类号： B24C3/02

    摘要： A cabinet device is provided for use in combination with an abrasive blasting system. The inner chamber of the cabinet device is maintained at a pressure of less than ambient air pressure during an abrading operation by applying a source of vacuum to an exhaust outlet in the bottom of the cabinet below the article being abraded which is supported on a rack in the chamber. A blasting gun in the chamber is manipulated from outside the cabinet by an operator. An inlet for ambient air is located in the cabinet above the article on the rack and, during an abrading operation, establishes a continuous current of air downwardly toward the cabinet exhaust outlet to clear the space in the cabinet above the rack of view-obscuring debris and dust caused by the blasting operation. An improved sealing device between the cabinet cover and the peripheral sidewall of the cabinet housing is also provided.

    摘要翻译： 提供了与喷砂系统组合使用的柜装置。 机柜装置的内腔在研磨操作期间保持在小于环境空气压力的压力下，通过将真空源施加到机架底部的排气出口下方，被磨损的物品被支撑在机架上 房间。 操作员从机柜外面操纵了室内的喷枪。 用于环境空气的入口位于机架上的物品上方的机柜中，并且在研磨操作期间，向室内排气口向下建立连续的空气流，以清除机柜上方的视野模糊碎片之上的空间 和由爆破作业引起的灰尘。 还提供了机柜盖和机壳外壳的外围侧壁之间的改进的密封装置。

    Abrading device
    8.
    发明授权
    Abrading device 失效
    磨损装置

    公开(公告)号：US4232487A

    公开(公告)日：1980-11-11

    申请号：US909537

    申请日：1978-05-25

    申请人： Donald J. Brown

    发明人： Donald J. Brown

    IPC分类号： B24C3/06 ,  B24C5/02 ,  B24C7/00

    CPC分类号： B24C5/02 ,  B24C3/065

    摘要： An abrasive surface treating device includes a gun connected to a pressurized air source, a housing containing a supply of abrasive material, an abrasive delivery line connected to the gun and having an aperture adjacent the housing outlet, a shroud to capture spent abrasive, and a vacuum source to draw spent abrasive and debris from the shroud back to the interior of the housing. The delivery of air at high velocity through the gun draws air through the abrasive delivery line via the aperture and thereby draws abrasive from the housing into the air stream flowing from the aperture to the gun so that the abrasive may be propelled against a work surface. The effective size of the aperture may be changed to alter the flow rate of various abrasive materials. In addition, the gun and abrasive delivery line may be connected to an adapter which, in turn, receives a shroud member having a configuration selected in accordance with the shape of the work surface.

    摘要翻译： 研磨表面处理装置包括连接到加压空气源的枪，包含磨料的供应的壳体，连接到枪的磨料输送管线和邻近壳体出口的孔，用于捕获废磨料的护罩和 真空源将废旧的磨料和碎屑从护罩上回到壳体的内部。 通过喷枪高速输送空气将空气通过研磨剂输送管线通过孔，从而将研磨剂从壳体吸入从孔到喷枪的气流中，使得磨料可以被推向工作表面。 可以改变孔径的有效尺寸以改变各种磨料的流速。 另外，喷枪和磨料输送管线可以连接到适配器，该适配器又接收具有根据工作表面的形状选择的配置的护罩构件。

    Picture screen
    9.
    发明授权
    Picture screen 失效
    图片屏幕

    公开(公告)号：US4169658A

    公开(公告)日：1979-10-02

    申请号：US871960

    申请日：1978-01-24

    申请人： Donald J. Brown

    发明人： Donald J. Brown

    IPC分类号： G03B21/58 ,  G03B21/56

    CPC分类号： G03B21/58

    摘要： A picture screen comprising an upright standard, a leg unit supporting the standard, a roller adapted to receive a picture screen, a picture screen mounted on the roller and adapted to be unwound from a closed position to an open position, an elongated screen casing for receiving the roller and the screen coupled to the upright standard, and casing extensions integrally formed with the screen casing and each being provided with a speaker mounted therein. The speakers project the sound toward the viewer/listener to provide a lifelike effect with the picture projected on the screen.

    摘要翻译： 一种包括直立标准的图像屏幕，支撑该标准的支腿单元，适于接收图像屏幕的滚筒，安装在滚筒上并适于从关闭位置退绕到打开位置的图像屏幕，用于 接收滚筒和连接到直立标准的屏幕，以及与屏幕壳体整体形成的壳体延伸部，并且每个设置有安装在其中的扬声器。 扬声器将声音投射到观看者/收听者，以便在屏幕上投射的图像提供逼真的效果。