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公开(公告)号：US07893217B2
公开(公告)日：2011-02-22
申请号：US11981132
申请日：2007-10-30
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , C12P21/04 , C07H21/04
CPC分类号： C07K14/78 , A61K38/00 , C07K14/4748
摘要： The present invention relates to novel human extracellular matrix polypeptides, designated RG1, polynucleotides encoding the polypeptides, methods for producing the polypeptides, expression vectors and genetically engineered host cells for expression of the polypeptides. The invention further relates to antibodies directed against the polypeptides and to methods for using the polynucleotides, and polypeptides, and antibodies in research, diagnosis, and therapeutic applications.
摘要翻译： 本发明涉及新的人细胞外基质多肽，称为RG1，编码多肽的多核苷酸，用于产生多肽的方法，表达载体和用于表达多肽的遗传工程改造的宿主细胞。 本发明还涉及针对多肽的抗体以及在研究，诊断和治疗应用中使用多核苷酸，多肽和抗体的方法。
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2.发明授权Methods for treating disease-states associated with RG1 using immunoconjugates 失效使用免疫缀合物治疗与RG1相关的疾病状态的方法公开(公告)号：US07887804B2
公开(公告)日：2011-02-15
申请号：US11981240
申请日：2007-10-30
IPC分类号： A61K39/395 , C12P21/04 , C12P21/08 , C07H21/04 , C07H16/00
CPC分类号： C07K14/78 , A61K38/00 , C07K14/4748
摘要： The present invention relates to novel human extracellular matrix polypeptides, designated RG1, polynucleotides encoding the polypeptides, methods for producing the polypeptides, expression vectors and genetically engineered host cells for expression of the polypeptides. The invention further relates to antibodies directed against the polypeptides and to methods for using the polynucleotides, and polypeptides, and antibodies in research, diagnosis, and therapeutic applications.
摘要翻译： 本发明涉及新的人细胞外基质多肽，称为RG1，编码多肽的多核苷酸，用于产生多肽的方法，表达载体和用于表达多肽的遗传工程改造的宿主细胞。 本发明还涉及针对多肽的抗体以及在研究，诊断和治疗应用中使用多核苷酸，多肽和抗体的方法。
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公开(公告)号：US20090292112A1
公开(公告)日：2009-11-26
申请号：US11981132
申请日：2007-10-30
IPC分类号： C07K16/00
CPC分类号： C07K14/78 , A61K38/00 , C07K14/4748
摘要： The present invention relates to novel human extracellular matrix polypeptides, designated RG1, polynucleotides encoding the polypeptides, methods for producing the polypeptides, expression vectors and genetically engineered host cells for expression of the polypeptides. The invention further relates to antibodies directed against the polypeptides and to methods for using the polynucleotides, and polypeptides, and antibodies in research, diagnosis, and therapeutic applications.
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公开(公告)号：US20090214422A1
公开(公告)日：2009-08-27
申请号：US11981240
申请日：2007-10-30
IPC分类号： A61K51/10 , A61K39/395 , A61P35/00
CPC分类号： C07K14/78 , A61K38/00 , C07K14/4748
摘要： The present invention relates to novel human extracellular matrix polypeptides, designated RG1, polynucleotides encoding the polypeptides, methods for producing the polypeptides, expression vectors and genetically engineered host cells for expression of the polypeptides. The invention further relates to antibodies directed against the polypeptides and to methods for using the polynucleotides, and polypeptides, and antibodies in research, diagnosis, and therapeutic applications.
摘要翻译： 本发明涉及新的人细胞外基质多肽，称为RG1，编码多肽的多核苷酸，用于产生多肽的方法，表达载体和用于表达多肽的遗传工程改造的宿主细胞。 本发明还涉及针对多肽的抗体以及在研究，诊断和治疗应用中使用多核苷酸，多肽和抗体的方法。
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公开(公告)号：US07335748B2
公开(公告)日：2008-02-26
申请号：US10895183
申请日：2004-07-20
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , C12P21/04 , C07H21/04
CPC分类号： G01N33/57434 , A61K47/6851 , A61K51/1045 , A61K2039/505 , C07K16/3076 , C07K2317/21 , C07K2317/56 , C12Q1/6886 , G01N33/57484
摘要： The present invention relates to antibodies, and antigen-binding antibody fragments, directed against an RG1 polypeptide. The invention further relates to methods for utilizing the antibodies, and antibody fragments, for diagnostic and therapeutic applications.
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公开(公告)号：US07608263B2
公开(公告)日：2009-10-27
申请号：US11981123
申请日：2007-10-30
IPC分类号： A61K39/395 , C12P21/04 , C12P21/08 , C07H21/04 , C07K16/00
CPC分类号： G01N33/57434 , A61K47/6851 , A61K51/1045 , A61K2039/505 , C07K16/3076 , C07K2317/21 , C07K2317/56 , C12Q1/6886 , G01N33/57484
摘要： The present invention relates to antibodies, and antigen-binding antibody fragments, directed against an RG1 polypeptide. The invention further relates to methods for utilizing the antibodies, and antibody fragments, for diagnostic and therapeutic applications.
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公开(公告)号：US20100081795A1
公开(公告)日：2010-04-01
申请号：US12560363
申请日：2009-09-15
IPC分类号： C07K16/00
CPC分类号： G01N33/57434 , A61K47/6851 , A61K51/1045 , A61K2039/505 , C07K16/3076 , C07K2317/21 , C07K2317/56 , C12Q1/6886 , G01N33/57484
摘要： The present invention relates to antibodies, and antigen-binding antibody fragments, directed against an RG1 polypeptide. The invention further relates to methods for utilizing the antibodies, and antibody fragments, for diagnostic and therapeutic applications.
摘要翻译： 本发明涉及针对RG1多肽的抗体和抗原结合抗体片段。 本发明还涉及用于诊断和治疗应用的用于使用抗体和抗体片段的方法。
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公开(公告)号：US07611706B2
公开(公告)日：2009-11-03
申请号：US11981219
申请日：2007-10-30
IPC分类号： A61K39/395 , C12P21/04 , C12P21/08 , C07H21/04 , C07K16/00
CPC分类号： G01N33/57434 , A61K47/6851 , A61K51/1045 , A61K2039/505 , C07K16/3076 , C07K2317/21 , C07K2317/56 , C12Q1/6886 , G01N33/57484
摘要： The present invention relates to antibodies, and antigen-binding antibody fragments, directed against an RG1 polypeptide. The invention further relates to methods for utilizing the antibodies, and antibody fragments, for diagnostic and therapeutic applications.
摘要翻译： 本发明涉及针对RG1多肽的抗体和抗原结合抗体片段。 本发明还涉及用于诊断和治疗应用的用于使用抗体和抗体片段的方法。
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公开(公告)号：US20080226656A1
公开(公告)日：2008-09-18
申请号：US11981219
申请日：2007-10-30
IPC分类号： A61K39/44
CPC分类号： G01N33/57434 , A61K47/6851 , A61K51/1045 , A61K2039/505 , C07K16/3076 , C07K2317/21 , C07K2317/56 , C12Q1/6886 , G01N33/57484
摘要： The present invention relates to antibodies, and antigen-binding antibody fragments, directed against an RG1 polypeptide. The invention further relates to methods for utilizing the antibodies, and antibody fragments, for diagnostic and therapeutic applications.
摘要翻译： 本发明涉及针对RG1多肽的抗体和抗原结合抗体片段。 本发明还涉及用于诊断和治疗应用的用于使用抗体和抗体片段的方法。
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公开(公告)号：US20080138899A1
公开(公告)日：2008-06-12
申请号：US11981123
申请日：2007-10-30
IPC分类号： C12N5/00
CPC分类号： G01N33/57434 , A61K47/6851 , A61K51/1045 , A61K2039/505 , C07K16/3076 , C07K2317/21 , C07K2317/56 , C12Q1/6886 , G01N33/57484
摘要： The present invention relates to antibodies, and antigen-binding antibody fragments, directed against an RG1 polypeptide. The invention further relates to methods for utilizing the antibodies, and antibody fragments, for diagnostic and therapeutic applications.
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