公开(公告)号：US08715771B2

公开(公告)日：2014-05-06

申请号：US12563045

申请日：2009-09-18

申请人： Dennis R. Orosa ,  John E. Papp ,  Hung T. Nguyen ,  Stephen D. Pacetti ,  Dudley Shelton Jayasinghe ,  Matthew J. Gillick

发明人： Dennis R. Orosa ,  John E. Papp ,  Hung T. Nguyen ,  Stephen D. Pacetti ,  Dudley Shelton Jayasinghe ,  Matthew J. Gillick

IPC分类号： B05D3/00

CPC分类号： A61F2/82 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/608 ,  A61L2420/02 ,  A61L2420/08

摘要： A coated implantable medical device and a method of coating an implantable medical device is disclosed, the method includes applying a composition onto the device and drying the composition at elevated temperature in an environment having increased relative humidity. A pre-screening method for a manufacturing lot of coated stents to determine the number of drug coating layers for a desired drug release rate is disclosed. The method including coating and testing small groups of stents, and applying the results of the tests to determine the number of drug coating layers to apply to the manufacturing lot of stents.

摘要翻译： 公开了涂覆的可植入医疗装置和涂覆可植入医疗装置的方法，所述方法包括将组合物施加到装置上并在具有相对湿度增加的环境中在升高的温度下干燥组合物。 公开了一种用于确定所需药物释放速率的药物涂层数量的涂层支架制造批次的预筛选方法。 该方法包括涂覆和测试小组支架，并应用测试结果确定应用于支架制造批次的药物涂层数量。

公开(公告)号：US20100104734A1

公开(公告)日：2010-04-29

申请号：US12563045

申请日：2009-09-18

申请人： Dennis R. Orosa ,  John E. Papp ,  Hung T. Nguyen ,  Stephen D. Pacetti ,  Dudley Shelton Jayasinghe ,  Mathew J. Gillick

发明人： Dennis R. Orosa ,  John E. Papp ,  Hung T. Nguyen ,  Stephen D. Pacetti ,  Dudley Shelton Jayasinghe ,  Mathew J. Gillick

IPC分类号： B05D5/00

CPC分类号： A61F2/82 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/608 ,  A61L2420/02 ,  A61L2420/08

摘要： A coated implantable medical device and a method of coating an implantable medical device is disclosed, the method includes applying a composition onto the device and drying the composition at elevated temperature in an environment having increased relative humidity. A pre-screening method for a manufacturing lot of coated stents to determine the number of drug coating layers for a desired drug release rate is disclosed. The method including coating and testing small groups of stents, and applying the results of the tests to determine the number of drug coating layers to apply to the manufacturing lot of stents.

摘要翻译： 公开了涂覆的可植入医疗装置和涂覆可植入医疗装置的方法，所述方法包括将组合物施加到装置上并在具有相对湿度增加的环境中在升高的温度下干燥组合物。 公开了一种用于确定所需药物释放速率的药物涂层数量的涂层支架制造批次的预筛选方法。 该方法包括涂覆和测试小组支架，并应用测试结果确定应用于支架制造批次的药物涂层数量。