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    Polymers of fluorinated monomers and hydrocarbon monomers
    5.
    发明授权
    Polymers of fluorinated monomers and hydrocarbon monomers 有权
    氟化单体和烃单体的聚合物

    公开(公告)号：US09339592B2

    公开(公告)日：2016-05-17

    申请号：US11784997

    申请日：2007-04-09

    申请人： Stephen D. Pacetti

    发明人： Stephen D. Pacetti

    IPC分类号： C08L27/12 ,  C08L23/04 ,  A61L31/04 ,  A61L31/10 ,  A61L31/16 ,  C08F214/18 ,  C08F295/00 ,  C09D127/16 ,  A61K31/436

    CPC分类号： A61L31/048 ,  A61K31/436 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  C08F214/18 ,  C08F295/00 ,  C09D127/16 ,  C08L27/12 ,  A61K31/10

    摘要： A polymer of fluorinated monomers and hydrocarbon monomers is provided. It is also provided a polymer blend that contains a polymer-formed of fluorinated monomers and hydrocarbon monomers and another biocompatible polymer. The polymer or polymer blend described herein and optionally a bioactive agent can form an implantable device such as a stent or a coating on an implantable device such as a drug-delivery stent, which can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

    摘要翻译： 提供氟化单体和烃单体的聚合物。 还提供了一种聚合物共混物，其包含由氟化单体和烃单体和另一种生物相容性聚合物形成的聚合物。 本文所述的聚合物或聚合物共混物和任选的生物活性剂可以在诸如药物递送支架的可植入装置上形成可植入装置，例如支架或涂层，其可用于治疗或预防动脉粥样硬化， 血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖，胆管阻塞，输尿管梗阻，肿瘤阻塞或其组合。

    Method for electrostatic coating of a medical device balloon
    7.
    发明授权
    Method for electrostatic coating of a medical device balloon 有权
    医疗器械气囊的静电涂覆方法

    公开(公告)号：US08883244B2

    公开(公告)日：2014-11-11

    申请号：US13600038

    申请日：2012-08-30

    申请人： Cameron K. Kerrigan ,  Stephen D. Pacetti

    发明人： Cameron K. Kerrigan ,  Stephen D. Pacetti

    IPC分类号： B05D3/00 ,  A61L31/14 ,  A61L31/16

    CPC分类号： A61L31/08 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2420/02 ,  B05D1/007

    摘要： A method for electrostatic coating of medical devices such as stents and balloons is described. The method includes applying a composition to a polymeric component of a medical device which has little or no conductivity. The polymeric component could be a material from which the body or a strut of the stent is made or could be a polymeric coating pre-applied on the stent. The polymeric component could be the balloon wall. A charge can then be applied to the polymeric component or the polymeric component can be grounded. Charged particles of drugs, polymers, biobeneficial agents, or any combination of these can then be electrostatically deposited on the medical device or the coating on the medical device. One example of the composition is iodine, iodine, iodide, iodate, a complex or salt thereof which can also impart imaging capabilities to the medical device.

    摘要翻译： 描述了诸如支架和气囊的医疗装置的静电涂覆方法。 该方法包括将组合物施用于具有很少或不具有导电性的医疗器械的聚合物组分。 聚合物组分可以是制造支架的主体或支柱的材料，或者可以是预先施加在支架上的聚合物涂层。 聚合物组分可以是球囊壁。 然后可以向聚合物组分施加电荷，或者聚合物组分可以接地。 药物，聚合物，生物有益剂或它们的任何组合的带电颗粒然后可以静电沉积在医疗装置或医疗装置上的涂层上。 组合物的一个实例是碘，碘，碘化物，碘酸盐，其复合物或盐，其也可以赋予医疗装置成像能力。

    Amorphous poly(D,L-lactide) coating
    9.
    发明授权
    Amorphous poly(D,L-lactide) coating 有权
    无定形聚（D，L-丙交酯）涂层

    公开(公告)号：US08778375B2

    公开(公告)日：2014-07-15

    申请号：US11117813

    申请日：2005-04-29

    申请人： Stephen D. Pacetti ,  Syed Faiyaz Ahmed Hossainy ,  David C. Gale

    发明人： Stephen D. Pacetti ,  Syed Faiyaz Ahmed Hossainy ,  David C. Gale

    IPC分类号： A61F2/00 ,  A61F2/82

    CPC分类号： A61L31/10 ,  A61L31/06 ,  A61L31/148 ,  A61L31/16 ,  C08L101/00 ,  C09D167/04 ,  C08L67/04 ,  C08L2666/02

    摘要： Implantable devices formed of or coated with a material that includes an amorphous poly(D,L-lactide) formed of a starting material such as meso-D,L-lactide are provided. The implantable device can be used for the treatment, mitigation, prevention, or inhibition of a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

    摘要翻译： 提供由包含由诸如内消旋-D，L-丙交酯的原料形成的无定形聚（D，L-丙交酯）的材料形成或涂覆的可植入装置。 可植入装置可用于治疗，缓解，预防或抑制动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，卵圆孔未闭，跛行， 静脉和人造移植物的吻合增殖，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。