公开(公告)号：US4000284A

公开(公告)日：1976-12-28

申请号：US611092

申请日：1975-09-08

申请人： Amedeo Failli ,  William T. Robinson ,  Dushan Dvornik

发明人： Amedeo Failli ,  William T. Robinson ,  Dushan Dvornik

IPC分类号： C07C59/68 ,  C07D213/30 ,  A61K31/395 ,  C07D213/55

CPC分类号： C07D213/30 ,  C07C59/68

摘要： Salts of phenoxyisobutyric acids with amino acid pyridylmethyl esters are disclosed. The salts possess antihyperlipoproteinemic activity. In addition, methods for their preparation and use, as well as pharmaceutical compositions thereof, are disclosed.

公开(公告)号：US4169202A

公开(公告)日：1979-09-25

申请号：US912798

申请日：1978-06-05

申请人： Ivo L. Jirkovsky ,  Dushan Dvornik ,  Mitchell N. Cayen

发明人： Ivo L. Jirkovsky ,  Dushan Dvornik ,  Mitchell N. Cayen

IPC分类号： A61K31/34 ,  A61K31/341 ,  A61K31/44 ,  A61K31/443 ,  A61P3/06 ,  C07C33/30 ,  C07C45/31 ,  C07D307/00 ,  C07D307/68 ,  C07D309/36 ,  C07D405/00 ,  C07D405/12

CPC分类号： C07D309/36 ,  C07C33/30 ,  C07C45/31 ,  C07D307/68

摘要： Derivatives of 4,5-dihydro-4-oxofuran-2-carboxylic acid characterized by having two substituents at position 5 and in addition being optionally further substituted at position 3 with a lower alkyl group, as well as esters therefor are disclosed. The foregoing compounds are useful hypolipidemic agents in a mammal. Novel methods for the preparation of these compounds also are disclosed.

摘要翻译： 特征在于在5位具有两个取代基，另外任选地在3位被低级烷基取代的PG，1的4,5-二氢-4-氧代呋喃-2-羧酸衍生物，以及其酯是 披露 上述化合物是哺乳动物中有用的降血脂药。 还公开了制备这些化合物的新方法。

公开(公告)号：US4244958A

公开(公告)日：1981-01-13

申请号：US38028

申请日：1979-05-10

申请人： Ivo L. Jirkovsky ,  Dushan Dvornik ,  Mitchell N. Cayen

发明人： Ivo L. Jirkovsky ,  Dushan Dvornik ,  Mitchell N. Cayen

IPC分类号： C07C29/42 ,  C07C45/31 ,  C07D307/68 ,  C07D309/36 ,  A61K31/34 ,  A61K31/445 ,  C07D213/55

CPC分类号： C07D309/36 ,  C07C29/42 ,  C07C45/31 ,  C07D307/68

摘要： Derivatives of 4,5-dihydro-4-oxofuran-2-carboxylic acid characterized by having two substituents at position 5 and in addition being optionally further substituted at position 3 with a lower alkyl group, as well as esters therefor are disclosed. The foregoing compounds are useful hypolipidemic agents in a mammal. Novel methods for the preparation of these compounds also are disclosed.

摘要翻译： 特征在于在5位具有两个取代基，另外在3位任选进一步被低级烷基取代的4,5-二氢-4-氧代呋喃-2-羧酸的衍生物及其酯。 上述化合物是哺乳动物中有用的降血脂药。 还公开了制备这些化合物的新方法。