公开(公告)号：US20230115636A1

公开(公告)日：2023-04-13

申请号：US17518736

申请日：2021-11-04

申请人： Michael E. Coughlin

发明人： Michael E. Coughlin

IPC分类号： A61F5/44

摘要： A support system for a urine collection bag includes a waistband; a strap having a first end connected to the urine collection bag and a second end connected to the belt; and a fastener on the second end of the strap. The waistband and strap support the weight of the urine collection bag so it doesn't creep down the patient's leg and tug on the catheter and permits the patient to reposition the urine collection bag quickly and easily.

公开(公告)号：US09040234B2

公开(公告)日：2015-05-26

申请号：US13218259

申请日：2011-08-25

申请人： Radhakrishnan P. Iyer ,  John E. Coughlin

发明人： Radhakrishnan P. Iyer ,  John E. Coughlin

IPC分类号： A61K31/713 ,  A61K31/7084 ,  A61P31/00 ,  A61P31/12 ,  C07H21/04 ,  C12Q1/68 ,  C12Q1/70 ,  C25B7/00 ,  G01N27/447 ,  G01N33/559

CPC分类号： C12N15/1131 ,  A61K31/7084 ,  A61K31/713 ,  C07H21/04 ,  C12N2310/14 ,  C12N2310/17 ,  C12N2310/315 ,  C12N2320/30

摘要： The invention relates to design of short oligonucleotides and analogs thereof (such as, di-, and trinucleotide compounds) useful for various therapeutic applications. It is believed that the compounds of the invention can be used as antiviral agents, anticancer agents and so on. In certain embodiments, the compounds of the invention can modulate immune-stimulatory pathways and non-TLR pathways. The invention also relates to design modified oligonucleotides for therapeutic applications, by excluding nucleotide segments having off-target effects from the modified oligonucleotides. In another aspect, the invention provides pharmaceutical compositions including one or more compounds of the invention.It is believed that the compounds and compositions as described herein have therapeutic utility against a variety of diseases, including viral diseases, autoimmune diseases (such as, allergy, asthma, and inflammatory disorders) and cancer.

摘要翻译： 本发明涉及可用于各种治疗应用的短寡核苷酸及其类似物（例如，二核苷酸和三核苷酸化合物）的设计。 据信本发明的化合物可以用作抗病毒剂，抗癌剂等。 在某些实施方案中，本发明的化合物可以调节免疫刺激途径和非TLR途径。 本发明还涉及用于治疗应用的设计修饰的寡核苷酸，通过从经修饰的寡核苷酸排除具有脱靶效应的核苷酸区段。 另一方面，本发明提供包含一种或多种本发明化合物的药物组合物。 据信本文所述的化合物和组合物具有针对各种疾病（包括病毒性疾病，自身免疫性疾病（例如过敏，哮喘和炎性疾病））和癌症的治疗效用。

公开(公告)号：US5277935A

公开(公告)日：1994-01-11

申请号：US827374

申请日：1992-01-29

申请人： Thomas E. Coughlin

发明人： Thomas E. Coughlin

IPC分类号： D06N3/00 ,  B05D3/02

CPC分类号： D06N3/0056

摘要： Method of coating woven fabric with a first latex compound having a viscosity of 18,000 to 20,000 cps, and containing a fire resistant additive. Then coating with a second latex compound to produce a hose ducting fabric which is fire resistant. The second latex compound preferably contains a fire resistant additive also, and may be of a viscosity between 20,000-30,000 cps.

摘要翻译： 使用粘度为18,000〜20,000cps的第一胶乳化合物涂布织物并含有耐火添加剂的方法。 然后用第二胶乳化合物涂覆以产生耐火的软管管道织物。 第二胶乳化合物也优选含有耐火添加剂，并且粘度可以在20,000-30,000cps之间。

公开(公告)号：US4515844A

公开(公告)日：1985-05-07

申请号：US590960

申请日：1984-03-19

申请人： Thomas E. Coughlin

发明人： Thomas E. Coughlin

IPC分类号： A43B17/00 ,  B32B27/40 ,  B32B3/02 ,  B32B5/06 ,  B32B5/22

CPC分类号： B32B27/40 ,  A43B17/00 ,  Y10T428/23907 ,  Y10T428/249942 ,  Y10T428/249976 ,  Y10T428/249982 ,  Y10T428/249988

摘要： Footwear insulation material comprising a urethane membrane bonded to a foam layer by an adhesive system. Needle punched fibers are secured to the membrane and extend through and beyond the foam layer. Insulation material has a thermal insulation factor R of between about R18.0 to R19.0.

摘要翻译： 鞋类绝缘材料包括通过粘合剂体系结合到泡沫层的聚氨酯膜。 针刺的纤维固定到膜上并延伸穿过泡沫层并超过泡沫层。 绝缘材料的绝热系数R在约R18.0至R19.0之间。

公开(公告)号：US20120053226A1

公开(公告)日：2012-03-01

申请号：US13218259

申请日：2011-08-25

申请人： Radhakrishnan P. Iyer ,  John E. Coughlin

发明人： Radhakrishnan P. Iyer ,  John E. Coughlin

IPC分类号： A61K31/713 ,  A61K31/7084 ,  C12Q1/70 ,  C12Q1/68 ,  G01N33/559 ,  A61P31/12 ,  A61P31/00 ,  G01N27/447 ,  C25B7/00 ,  C07H21/04 ,  A61P35/00

CPC分类号： C12N15/1131 ,  A61K31/7084 ,  A61K31/713 ,  C07H21/04 ,  C12N2310/14 ,  C12N2310/17 ,  C12N2310/315 ,  C12N2320/30

摘要： The invention relates to design of short oligonucleotides and analogs thereof (such as, di-, and trinucleotide compounds) useful for various therapeutic applications. It is believed that the compounds of the invention can be used as antiviral agents, anticancer agents and so on. In certain embodiments, the compounds of the invention can modulate immune-stimulatory pathways and non-TLR pathways. The invention also relates to design modified oligonucleotides for therapeutic applications, by excluding nucleotide segments having off-target effects from the modified oligonucleotides. In another aspect, the invention provides pharmaceutical compositions including one or more compounds of the invention.It is believed that the compounds and compositions as described herein have therapeutic utility against a variety of diseases, including viral diseases, autoimmune diseases (such as, allergy, asthma, and inflammatory disorders) and cancer.

摘要翻译： 本发明涉及可用于各种治疗应用的短寡核苷酸及其类似物（例如，二核苷酸和三核苷酸化合物）的设计。 据信本发明的化合物可以用作抗病毒剂，抗癌剂等。 在某些实施方案中，本发明的化合物可以调节免疫刺激途径和非TLR途径。 本发明还涉及用于治疗应用的设计修饰的寡核苷酸，通过从经修饰的寡核苷酸排除具有脱靶效应的核苷酸区段。 另一方面，本发明提供包含一种或多种本发明化合物的药物组合物。 据信本文所述的化合物和组合物具有针对各种疾病（包括病毒性疾病，自身免疫性疾病（例如过敏，哮喘和炎性疾病））和癌症的治疗效用。

公开(公告)号：US07230519B2

公开(公告)日：2007-06-12

申请号：US10869595

申请日：2004-06-16

申请人： Michael E. Coughlin ,  Bernhard P. Knutsen ,  David E. Schloemer

发明人： Michael E. Coughlin ,  Bernhard P. Knutsen ,  David E. Schloemer

IPC分类号： G05B19/00 ,  G06F7/00 ,  G08B29/00 ,  H04B1/00 ,  H04Q1/00

CPC分类号： H04L63/105 ,  G06F21/35 ,  G07C9/00087 ,  G07C9/00103 ,  G07C9/00111 ,  H04L63/107

摘要： An identification tag (100) facilitates use of a secure computer system (300). The tag (100) is adapted to be worn on a user's wrist and includes an identification and registration circuit (102) that includes an identification component (106), an affiliation component (110), and a light-emitting diode (112). The computer system includes an RF identification tag registration device (302) operable to acquire user physical information and communicate the physical information to a computer (202), wherein the computer verifies that a valid user is wearing the tag (100). The identification and registration device (302) ensures that the physical information communicated to the computer pertains to the user wearing the tag by comparing pulse signals acquired from the user's hand and wrist as the device (302) is acquiring physical information. The computer (202) uses the identification information and the affiliation information to log the user into and out of the system (300), and to associate the identification information with a particular user.

摘要翻译： 识别标签（100）有助于安全计算机系统（300）的使用。 标签（100）适于戴在用户手腕上，并且包括识别和登记电路（102），其包括识别部件（106），附属部件（110）和发光二极管（112）。 计算机系统包括RF识别标签注册设备（302），其可操作以获取用户物理信息并将物理信息传送到计算机（202），其中所述计算机验证有效用户正在佩戴所述标签（100）。 识别和登记装置（302）通过比较装置（302）正在获取物理信息，比较从用户的手和手腕获取的脉冲信号，确保传送到计算机的物理信息与穿着标签的用户有关。 计算机（202）使用识别信息和附属信息来记录用户进出系统（300）并将识别信息与特定用户相关联。

公开(公告)号：US06910601B2

公开(公告)日：2005-06-28

申请号：US10615503

申请日：2003-07-08

申请人： Tracy I. Thomas ,  Michael E. Coughlin

发明人： Tracy I. Thomas ,  Michael E. Coughlin

IPC分类号： A61J7/00 ,  G07F5/18 ,  B65G59/00

CPC分类号： G07F5/18 ,  G07F11/002 ,  G07F17/0092

摘要： A collating unit (10) for use with a control center (12) cooperating with an automatic dispensing system (“ADS”) (14) for automatic storage of prescription containers dispensed from the ADS (14). The collating unit (10) broadly comprises an infeed conveyor (16) for transporting the prescription containers from the ADS (14) to the collating unit (10); a base (18) housed within the control center (12) and positioned generally adjacent to the infeed conveyor (16); a collating unit conveyor (20) mounted on the base (18); a frame (21) substantially surrounding and covering the infeed conveyor (16) and the base (18); a plurality of holding areas (22) formed within the frame (21); a plurality of guide arms (24) mounted on the base (18) between the infeed conveyor (16) and the collating unit conveyor (20) and operable to maneuver the containers from the infeed conveyor (16) into the plurality of holding areas (22); a plurality of sensors (26) to sense the presence of the containers within the collating unit (10); and a control system (28) for controlling operation of the infeed conveyor (16), the collating unit conveyor (20), the guide arms (24), and the sensors (26).

摘要翻译： 一种用于与自动分配系统（“ADS”）（14）配合的控制中心（12）的对照单元（10），用于自动存储从ADS（14）分配的处方容器。 整理单元（10）广泛地包括用于将处方容器从ADS（14）运送到对照单元（10）的进料输送机（16）; 容纳在所述控制中心（12）内并且大致邻近所述进料输送机（16）定位的基座（18）; 安装在基座（18）上的整理单元传送器（20）; 基本上围绕并覆盖进料输送机（16）和基座（18）的框架（21）; 形成在所述框架（21）内的多个保持区域（22）。 多个引导臂（24），其安装在进料输送机（16）和对照单元输送机（20）之间的基座（18）上，并且可操作以将容器从进料输送机（16）操纵到多个保持区域 22）; 多个传感器（26），用于感测整理单元（10）内容器的存在; 以及用于控制进料输送机（16），对比单元输送机（20），导向臂（24）和传感器（26）的操作的控制系统（28）。

公开(公告)号：US06883681B1

公开(公告)日：2005-04-26

申请号：US09457286

申请日：1999-12-08

申请人： Michael E. Coughlin ,  Arpita Banerjee ,  Lawrence E. Guerra ,  Keith W. Kudera ,  Ronald A. Leonard ,  Hamid Massali ,  David M. McDonald ,  Fred T. Steinbach ,  Tim Surgeon

发明人： Michael E. Coughlin ,  Arpita Banerjee ,  Lawrence E. Guerra ,  Keith W. Kudera ,  Ronald A. Leonard ,  Hamid Massali ,  David M. McDonald ,  Fred T. Steinbach ,  Tim Surgeon

IPC分类号： A61J7/00 ,  G07F11/00 ,  G07F11/42 ,  G07F11/58

CPC分类号： G07F11/58 ,  G06F19/00 ,  G07F11/165 ,  G07F11/42 ,  G07F17/0092

摘要： A storage and dispensing system (10) for storing and dispensing pre-packaged pharmaceutical products (12) and other products. The system includes a cabinet (14); a plurality of product conveyors (16) mounted within the cabinet and each configured for holding at least one product; an infeed conveyor (18) for receiving products that are to be stored in the cabinet; an outfeed conveyor (20) for receiving products that are to be dispensed from the cabinet; and a transporter (22) moveable within the cabinet for transporting products between the product conveyors and the infeed and outfeed conveyors for storing products in or dispensing products from the cabinet.

摘要翻译： 一种用于存储和分发预先包装的药品（12）和其他产品的储存和分配系统（10）。 该系统包括一个柜体（14）; 多个产品输送机（16），其安装在所述机柜内，并且每个产品输送机被配置用于容纳至少一个产品; 用于接收要存储在机柜中的产品的进料输送机（18）; 用于从橱柜接收要分配的产品的出料输送机（20） 以及在机柜内可移动的输送器（22），用于在产品输送机和进料和出料输送机之间运输产品，用于将产品存储在柜中或从橱柜中分配产品。

公开(公告)号：US06592005B1

公开(公告)日：2003-07-15

申请号：US10040823

申请日：2002-01-07

申请人： Shane P. Coughlin ,  Michael E. Coughlin ,  Stacy Orr ,  Timothy Surgeon

发明人： Shane P. Coughlin ,  Michael E. Coughlin ,  Stacy Orr ,  Timothy Surgeon

IPC分类号： B65G5900

CPC分类号： B25J19/027 ,  B25J15/0206 ,  G07F9/026 ,  G07F11/165 ,  G07F17/0092

摘要： A pill count sensor (10) comprises an electromagnetic energy emitting array (40) and an electromagnetic energy receiving array (42), with a pill detection zone (44) defined therebetween; a sensor amplifier (28); a control board (30) interfaced with a computing device (24); and interconnecting cabling (34, 36, 38). The electromagnetic energy emitting and receiving arrays (40,42) emit and receive, respectively, beams of electromagnetic energy (46) across the zone (44) such that any pill (50) entering the zone (44) is detected by a resulting disruption in received electromagnetic energy at the receiving array (42). The sensor amplifier (28) is operable to automatically self-calibrate in order to compensate for detected electromagnetic energy levels, and to generate a pill sense signal in response to a detected pill (50). The control board (30) is operable to increment a pill count.

摘要翻译： 药片计数传感器（10）包括电磁能量发射阵列（40）和电磁能量接收阵列（42），其中限定了药丸检测区（44）; 传感器放大器（28）; 与计算设备（24）接口的控制板（30）; 和互连电缆（34,36,38）。 电磁能发射和接收阵列（40,42）分别发射和接收穿过区域（44）的电磁能束（46），使得进入区域（44）的任何药丸（50）被产生的破坏 在接收阵列（42）处接收电磁能。 传感器放大器（28）可操作以自动自校准以便补偿检测到的电磁能量水平，并响应于检测到的药丸（50）产生药丸感测信号。 控制板（30）可操作以增加药丸计数。

公开(公告)号：US06318630B1

公开(公告)日：2001-11-20

申请号：US09583052

申请日：2000-05-30

申请人： Michael E. Coughlin ,  Christopher J. Thomsen ,  Claire P. Coughlin

发明人： Michael E. Coughlin ,  Christopher J. Thomsen ,  Claire P. Coughlin

IPC分类号： G06K710

CPC分类号： G06F19/326 ,  G06F19/00 ,  G06F19/3462 ,  G06K17/00

摘要： A preferred medicament dispensing station (10) includes a computer (16) with a bar code reader (18) and a printer (20) coupled therewith. When filling a prescription from a supply container (12) of a medicament, the bar code reader (18) scans the bar code (28) on the container (12) and a computer (16) compares the bar code data with prescription data to determine a match before activating a printer (20) to print a prescription label (30) for the prescription. The preferred station (10) also includes databases (26) including an attribute database and a language database. The computer (16) activates the printer (20) to print medicament indicia on the prescription label (30) representative of physical attributes of the medicament including a word description (32) such as the shape, color pattern, color, scoring and form and an image (34). The computer (16) is operable also to prompt the printer (20) to print prescription data on the same label or on a second label in a second language.

摘要翻译： 优选的药物分配站（10）包括具有条形码读取器（18）的计算机（16）和与其耦合的打印机（20）。 条形码阅读器（18）从药剂供给容器（12）填充处方时，扫描容器（12）上的条形码（28），计算机（16）将条形码数据与处方数据进行比较 在激活打印机（20）之前确定匹配以打印处方的处方标签（30）。 优选站（10）还包括包括属性数据库和语言数据库的数据库（26）。 计算机（16）激活打印机（20）以在代表药物的物理属性的处方标签（30）上打印药物标记，其包括诸如形状，颜色图案，颜色，评分和形式的单词描述（32） 图像（34）。 计算机（16）还可操作以提示打印机（20）以相同的标签或第二语言的第二标签打印处方数据。