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公开(公告)号：US20230113505A1
公开(公告)日：2023-04-13
申请号：US18079853
申请日：2022-12-12
申请人： ELECTROCORE, INC
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Methods and devices are disclosed for the non-invasive treatment of autoimmune diseases or disorders through the delivery of energy to target nervous tissue, particularly the vagus nerve.. A device for treating an autoimmune disease or disorder comprises one or more electrodes having a contact surface configured for contacting an anterior portion of an outer skin surface of a neck of a patient and an energy source coupled to the electrodes. The energy source is configured to generate one or more electrical impulses and to transmit the electrical impulses to the electrodes and transcutaneously through the anterior portion of the outer skin surface of the neck of the patient at or near a vagus nerve. The electrical impulses are sufficient to modulate the vagus nerve and to inhibit inflammation and treat the disorder.
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公开(公告)号：US11581090B2
公开(公告)日：2023-02-14
申请号：US16229299
申请日：2018-12-21
申请人： ElectroCore, Inc.
摘要： A system includes: a processor; a memory coupled to the processor, wherein the memory stores a first content; a medical device coupled to the processor; and a reader coupled to the processor, wherein the reader is configured to read a second content from a storage medium other than the memory such that the processor switches the medical device from a first mode to a second mode based on the first content corresponding to the second content.
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公开(公告)号：US20220378359A1
公开(公告)日：2022-12-01
申请号：US17874364
申请日：2022-07-27
申请人： ELECTROCORE, INC
发明人： Bruce J. Simon , Joseph P. Errico
摘要： Systems and methods for remote therapy and patient monitoring are provided. A method comprises contacting an outer skin surface of a patient with a contact surface of a stimulator and transmitting an electrical impulse from the stimulator transcutaneously through the outer skin surface to a nerve within the patient. Data related to parameters of the electrical impulse applied to the nerve is stored and transmitted to a remote source. The data may include duration of treatment, amplitude of the electrical impulse, compliance with a prescribed therapy regimen or other relevant data related to the therapy. The method may further include collecting patient status data, such as symptoms of a medical condition (e.g., severity of a headache) before, during and/or after stimulation. The patient status data is correlated with the treatment data to monitor compliance and/or the effectiveness of the therapy.
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公开(公告)号：US11458297B2
公开(公告)日：2022-10-04
申请号：US16404443
申请日：2019-05-06
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Transcutaneous electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including nasal or paranasal sinus symptoms that resemble an immune-mediated response (“sinus” headaches). The devices and methods may also be used to treat rhinitis, sinusitis, or rhinosinusitis, irrespective of whether those disorders are co-morbid with a headache. They may also be used to treat other disorders that may be co-morbid with migraine or cluster headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.
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公开(公告)号：US20220273939A1
公开(公告)日：2022-09-01
申请号：US17739100
申请日：2022-05-07
申请人： ELECTROCORE, INC
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Systems and methods for treating diseases and disorders in a patient are provided. A device comprises a stimulator comprising an electrode and an energy source. The energy source is configured to generate an electrical impulse and transmit the electrical impulse to the electrode through an outer skin surface to a vagus nerve of the patient. The device further comprises a sensor for detecting a physiological parameter of a patient's heart and a controller coupled to the stimulator and the sensor and configured to activate the stimulator based on the physiological parameter to cause the stimulator to generate the electrical impulse. In some aspects, the electrical impulse is sufficient to modulate the vagus nerve to treat a cardiac arrhythmia of the patient.
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公开(公告)号：US11406825B2
公开(公告)日：2022-08-09
申请号：US16416634
申请日：2019-05-20
申请人： ElectroCore, Inc.
发明人： Joseph P. Errico , Steven Mendez , Bruce J. Simon
IPC分类号： A61N1/36 , A61B5/00 , H04M1/21 , A61N1/04 , A61B5/11 , A61B5/24 , A61B5/377 , H04M1/02 , A61B8/00 , A61B5/352 , A61B5/375
摘要： Devices, systems and methods are disclosed that allow a patient to self-treat neurodegenerative diseases, such as dementia, Alzheimer's disease, ischemic stroke, post-concussion syndrome, chronic traumatic encephalopathy and the like by electrical noninvasive stimulation of a vagus nerve. The system comprises a handheld stimulator that is applied to the surface of the patient's neck, wherein the stimulator comprises or is joined to a smartphone. A camera of the smartphone may be used to position and reposition the stimulator to a particular location on the patient's neck. The system may also comprise a base station that is used to meter the charging of a rechargeable battery within the stimulator. The base station and stimulator transmit data to one another regarding the status of a stimulation session.
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公开(公告)号：US20220217479A1
公开(公告)日：2022-07-07
申请号：US17702051
申请日：2022-03-23
申请人： ELECTROCORE, INC
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Vagal nerve stimulation devices and methods are provided for treating medical conditions, such as conditions associated with insufficient dopamine and/or endogenous opioids in the brain. A device includes one or more electrodes having a contact surface for contacting an outer skin surface of a patient and an energy source coupled to the electrodes. The energy source generates one or more electrical impulses and transmits the electrical impulses to the electrodes and transcutaneously through the outer skin surface of the patient at or near a vagus nerve. The one or more electrical impulses is sufficient to modulate the vagus nerve and release dopamine and/or endogenous opioids in a brain of the patient.
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公开(公告)号：US20220079502A1
公开(公告)日：2022-03-17
申请号：US17514551
申请日：2021-10-29
申请人： electroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico
摘要： Systems and methods for remote therapy and patient monitoring are provided. A method comprises contacting an outer skin surface of a patient with a contact surface of a stimulator and transmitting an electrical impulse from the stimulator transcutaneously through the outer skin surface to a nerve within the patient. Data related to parameters of the electrical impulse applied to the nerve is stored and transmitted to a remote source. The data may include duration of treatment, amplitude of the electrical impulse, compliance with a prescribed therapy regimen or other relevant data related to the therapy. The method may further include collecting patient status data, such as symptoms of a medical condition (e.g., severity of a headache) before, during and/or after stimulation. The patient status data is correlated with the treatment data to monitor compliance and/or the effectiveness of the therapy.
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公开(公告)号：US20210353943A1
公开(公告)日：2021-11-18
申请号：US17390747
申请日：2021-07-30
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Methods and devices are disclosed for the non-invasive treatment of Parkinson's disease through the delivery of energy to target nervous tissue, particularly the vagus nerve. The methods and devices transmit an electrical impulse transcutaneously through an outer skin surface of the patient to modulate activity of the vagus nerve to treat one or more symptoms of Parkinson's disease. This modulation may inhibit neuroinflammation and/or increase levels of at least one neurotrophic factor to promote the survival of dopamine producing cells in patients suffering from the conditions of Parkinson's disease.
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公开(公告)号：US20210299435A1
公开(公告)日：2021-09-30
申请号：US17346265
申请日：2021-06-13
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico
摘要： Devices, systems and methods are disclosed for reducing inflammation associated with an aneurysm in a patient. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in the vagus nerve. Vagus nerve stimulation is used to modulate the release of neurotransmitters in the brain and to reduce inflammation that may lead to the formation, growth, rupture or hemorrhage of an aneurysm.
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